Nonlinear relationship between CAN current and $$Ca^{2+}$$ influx underpins synergistic action of muscarinic and NMDA receptors on bursts induction in midbrain dopaminergic neurons

2022 ◽  
Author(s):  
Mengjiao Chen ◽  
Fangqing Liu ◽  
Longying Wen ◽  
Xia Hu
Keyword(s):  
Nmda Receptors ◽  
Dopaminergic Neurons ◽  
Synergistic Action ◽  
Nonlinear Relationship ◽  
Midbrain Dopaminergic Neurons

Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration

2021 ◽  
Author(s):  
Susan R. Goulding ◽  
Martin Lévesque ◽  
Aideen M. Sullivan ◽  
Louise M. Collins ◽  
Gerard W. O’Keeffe
Keyword(s):  
Dopaminergic Neurons ◽  
Neurite Growth ◽  
Smad Pathway ◽  
Midbrain Dopaminergic Neurons

New inputs to midbrain dopaminergic neurons: A new corticobasal ganglia model?

2013 ◽  
Vol 28 (2) ◽  
pp. 124-124
Author(s):  
Ines Trigo-Damas
Keyword(s):  
Dopaminergic Neurons ◽  
Midbrain Dopaminergic Neurons

scholarly journals Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons

2015 ◽  
Vol 35 (31) ◽  
pp. 11144-11152 ◽  
Author(s):  
E. Piccart ◽  
N. A. Courtney ◽  
S. Y. Branch ◽  
C. P. Ford ◽  
M. J. Beckstead
Keyword(s):  
Dopaminergic Neurons ◽  
Dopamine Autoreceptor ◽  
Midbrain Dopaminergic Neurons

Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories

2021 ◽  
Vol 118 (40) ◽  
pp. e2111069118
Author(s):  
Theodoros Tsetsenis ◽  
Julia K. Badyna ◽  
Julianne A. Wilson ◽  
Xiaowen Zhang ◽  
Elizabeth N. Krizman ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Dorsal Hippocampus ◽  
Memory Formation ◽  
Dopamine Neurons ◽  
Substantia Nigra Pars Compacta ◽  
Aversive Learning ◽  
Contextual Fear ◽  
Dopaminergic Transmission ◽  
Midbrain Dopaminergic Neurons ◽  
Midbrain Dopamine

Aversive memories are important for survival, and dopaminergic signaling in the hippocampus has been implicated in aversive learning. However, the source and mode of action of hippocampal dopamine remain controversial. Here, we utilize anterograde and retrograde viral tracing methods to label midbrain dopaminergic projections to the dorsal hippocampus. We identify a population of midbrain dopaminergic neurons near the border of the substantia nigra pars compacta and the lateral ventral tegmental area that sends direct projections to the dorsal hippocampus. Using optogenetic manipulations and mutant mice to control dopamine transmission in the hippocampus, we show that midbrain dopamine potently modulates aversive memory formation during encoding of contextual fear. Moreover, we demonstrate that dopaminergic transmission in the dorsal CA1 is required for the acquisition of contextual fear memories, and that this acquisition is sustained in the absence of catecholamine release from noradrenergic terminals. Our findings identify a cluster of midbrain dopamine neurons that innervate the hippocampus and show that the midbrain dopamine neuromodulation in the dorsal hippocampus is sufficient to maintain aversive memory formation.

scholarly journals Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons

1998 ◽  
Vol 18 (13) ◽  
pp. 4929-4937 ◽  
Author(s):  
Brian A. Horger ◽  
Merry C. Nishimura ◽  
Mark P. Armanini ◽  
Li-Chong Wang ◽  
Kris T. Poulsen ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Midbrain Dopaminergic Neurons ◽  
And Function

scholarly journals Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression

2009 ◽  
Vol 4 (1) ◽  
pp. 11 ◽  
Author(s):  
Kambiz N Alavian ◽  
Paola Sgadò ◽  
Lavinia Alberi ◽  
Srinivasa Subramaniam ◽  
Horst H Simon
Keyword(s):  
Dopaminergic Neurons ◽  
Midbrain Dopaminergic Neurons
Sign in / Sign up

Export Citation Format

Share Document