New inputs to midbrain dopaminergic neurons: A new corticobasal ganglia model?

2013 ◽  
Vol 28 (2) ◽  
pp. 124-124
Author(s):  
Ines Trigo-Damas
Keyword(s):  
Dopaminergic Neurons ◽  
Midbrain Dopaminergic Neurons

Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration

2021 ◽  
Author(s):  
Susan R. Goulding ◽  
Martin Lévesque ◽  
Aideen M. Sullivan ◽  
Louise M. Collins ◽  
Gerard W. O’Keeffe
Keyword(s):  
Dopaminergic Neurons ◽  
Neurite Growth ◽  
Smad Pathway ◽  
Midbrain Dopaminergic Neurons

scholarly journals Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons

2015 ◽  
Vol 35 (31) ◽  
pp. 11144-11152 ◽  
Author(s):  
E. Piccart ◽  
N. A. Courtney ◽  
S. Y. Branch ◽  
C. P. Ford ◽  
M. J. Beckstead
Keyword(s):  
Dopaminergic Neurons ◽  
Dopamine Autoreceptor ◽  
Midbrain Dopaminergic Neurons

Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories

2021 ◽  
Vol 118 (40) ◽  
pp. e2111069118
Author(s):  
Theodoros Tsetsenis ◽  
Julia K. Badyna ◽  
Julianne A. Wilson ◽  
Xiaowen Zhang ◽  
Elizabeth N. Krizman ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Dorsal Hippocampus ◽  
Memory Formation ◽  
Dopamine Neurons ◽  
Substantia Nigra Pars Compacta ◽  
Aversive Learning ◽  
Contextual Fear ◽  
Dopaminergic Transmission ◽  
Midbrain Dopaminergic Neurons ◽  
Midbrain Dopamine

Aversive memories are important for survival, and dopaminergic signaling in the hippocampus has been implicated in aversive learning. However, the source and mode of action of hippocampal dopamine remain controversial. Here, we utilize anterograde and retrograde viral tracing methods to label midbrain dopaminergic projections to the dorsal hippocampus. We identify a population of midbrain dopaminergic neurons near the border of the substantia nigra pars compacta and the lateral ventral tegmental area that sends direct projections to the dorsal hippocampus. Using optogenetic manipulations and mutant mice to control dopamine transmission in the hippocampus, we show that midbrain dopamine potently modulates aversive memory formation during encoding of contextual fear. Moreover, we demonstrate that dopaminergic transmission in the dorsal CA1 is required for the acquisition of contextual fear memories, and that this acquisition is sustained in the absence of catecholamine release from noradrenergic terminals. Our findings identify a cluster of midbrain dopamine neurons that innervate the hippocampus and show that the midbrain dopamine neuromodulation in the dorsal hippocampus is sufficient to maintain aversive memory formation.

scholarly journals Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons

1998 ◽  
Vol 18 (13) ◽  
pp. 4929-4937 ◽  
Author(s):  
Brian A. Horger ◽  
Merry C. Nishimura ◽  
Mark P. Armanini ◽  
Li-Chong Wang ◽  
Kris T. Poulsen ◽  
...  
Keyword(s):  
Dopaminergic Neurons ◽  
Midbrain Dopaminergic Neurons ◽  
And Function

scholarly journals Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression

2009 ◽  
Vol 4 (1) ◽  
pp. 11 ◽  
Author(s):  
Kambiz N Alavian ◽  
Paola Sgadò ◽  
Lavinia Alberi ◽  
Srinivasa Subramaniam ◽  
Horst H Simon
Keyword(s):  
Dopaminergic Neurons ◽  
Midbrain Dopaminergic Neurons

scholarly journals Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage

2020 ◽  
Vol 21 (18) ◽  
pp. 6589
Author(s):  
Giulia Gaggi ◽  
Andrea Di Credico ◽  
Pascal Izzicupo ◽  
Francesco Alviano ◽  
Michele Di Mauro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Dopaminergic Neurons ◽  
High Efficiency ◽  
Ethical Issues ◽  
Differentiation Potential ◽  
Homogeneous Population ◽  
Human Mesenchymal Stromal Cells ◽  
Midbrain Dopaminergic Neurons

Degeneration of dopaminergic neurons represents the cause of many neurodegenerative diseases, with increasing incidence worldwide. The replacement of dead cells with new healthy ones may represent an appealing therapeutic approach to these pathologies, but currently, only pluripotent stem cells can generate dopaminergic neurons with high efficiency. However, with the use of these cells arises safety and/or ethical issues. Human mesenchymal stromal cells (hFM-MSCs) are perinatal stem cells that can be easily isolated from the amniochorionic membrane after delivery. Generally considered multipotent, their real differentiative potential is not completely elucidated. The aim of this study was to analyze their stemness characteristics and to evaluate whether they may overcome their mesenchymal fate, generating dopaminergic neurons. We demonstrated that hFM-MSCs expressed embryonal genes OCT4, NANOG, SOX2, KLF4, OVOL1, and ESG1, suggesting they have some features of pluripotency. Moreover, hFM-MSCs that underwent a dopaminergic differentiation protocol gradually increased the transcription of dopaminergic markers LMX1b, NURR1, PITX3, and DAT. We finally obtained a homogeneous population of cells resembling the morphology of primary midbrain dopaminergic neurons that expressed the functional dopaminergic markers TH, DAT, and Nurr1. In conclusion, our results suggested that hFM-MSCs retain the expression of pluripotency genes and are able to differentiate not only into mesodermal cells, but also into neuroectodermal dopaminergic neuron-like cells.

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