Intrastriatal gene transfer of vascular endothelial growth factor rescues dopaminergic neurons in a rat Parkinson’s disease model

2006 ◽  
Vol 26 (6) ◽  
pp. 670-673 ◽  
Author(s):  
Youyong Tian ◽  
Shenggang Sun ◽  
Cuiju Tang ◽  
Jianing Wang ◽  
Xiaowu Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Vascular Endothelial Growth Factor ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Gene Transfer ◽  
Dopaminergic Neurons ◽  
Disease Model ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Insights into the Mechanisms Involved in Protective Effects of VEGF-B in Dopaminergic Neurons

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Beatrice Caballero ◽  
Scott J. Sherman ◽  
Torsten Falk
Keyword(s):  
Parkinson’S Disease ◽  
Vascular Endothelial Growth Factor ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Dopaminergic Neurons ◽  
Protective Factor ◽  
Angiogenic Factor ◽  
Vascular Endothelial ◽  
Area Of Interest ◽  
Endothelial Growth Factor

Vascular endothelial growth factor-B (VEGF-B), when initially discovered, was thought to be an angiogenic factor, due to its intimate sequence homology and receptor binding similarity to the prototype angiogenic factor, vascular endothelial growth factor-A (VEGF-A). Studies demonstrated that VEGF-B, unlike VEGF-A, did not play a significant role in angiogenesis or vascular permeability and has become an active area of interest because of its role as a survival factor in pathological processes in a multitude of systems, including the brain. By characterization of important downstream targets of VEGF-B that regulate different cellular processes in the nervous system and cardiovascular system, it may be possible to develop more effective clinical interventions in diseases such as Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS), and ischemic heart disease, which all share mitochondrial dysfunction as part of the disease. Here we summarize what is currently known about the mechanism of action of VEGF-B in pathological processes. We explore its potential as a homeostatic protective factor that improves mitochondrial function in the setting of cardiovascular and neurological disease, with a specific focus on dopaminergic neurons in Parkinson’s disease.

Vascular endothelial growth factor-B is neuroprotective in an in vivo rat model of Parkinson's disease

2011 ◽  
Vol 496 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Torsten Falk ◽  
Xu Yue ◽  
Shiling Zhang ◽  
Alexander D. McCourt ◽  
Brandon J. Yee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Vascular Endothelial Growth Factor ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Rat Model ◽  
Vascular Endothelial ◽  
Factor B ◽  
Endothelial Growth Factor

Induction of pulmonary angiogenesis by adenoviral-mediated gene transfer of vascular endothelial growth factor

2004 ◽  
Vol 77 (2) ◽  
pp. 458-463 ◽  
Author(s):  
Virginie Lambert ◽  
René Michel ◽  
Guy-Michel Mazmanian ◽  
Elisabeth M Dulmet ◽  
André Capderou ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Gene Transfer ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
Sign in / Sign up

Export Citation Format

Share Document