Optimal threshold of stimulated serum thyroglobulin level for 18F-FDG PET/CT imaging in patients with thyroid cancer

2017 ◽  
Vol 37 (3) ◽  
pp. 429-432
Author(s):  
Hong Chai ◽  
Hu Zhang ◽  
Yong-li Yu ◽  
Yun-chao Gao
Keyword(s):  
Thyroid Cancer ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Optimal Threshold ◽  
Serum Thyroglobulin ◽  
Pet Ct ◽  
Thyroglobulin Level ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Unstimulated Serum Thyroglobulin Levels after Thyroidectomy and Radioiodine Therapy for Intermediate-Risk Thyroid Cancer Are Not Always a Reliable Marker of Lymph Node Recurrence: Case Report and a Lesson for Clinicians

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Luca Foppiani ◽  
Simona Sola ◽  
Manlio Cabria ◽  
Gianluca Bottoni ◽  
Arnoldo Piccardo
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Fdg Pet ◽  
Serum Thyroglobulin ◽  
Node Metastasis ◽  
Pet Ct ◽  
18F Fdg ◽  
Reliable Marker ◽  
Fdg Pet Ct

Over 50% of patients with papillary thyroid carcinoma (PTC) have cervical lymph-node metastasis on diagnosis, and up to 30% show nodal recurrence after surgery plus radioactive iodine (131I) (RAI) therapy. The combination of ultrasonography (US) and fine-needle aspiration cytology (FNAC) and the measurement of thyroglobulin (Tg) in washout fluid are cornerstones in the diagnosis of nodal metastasis. In the absence of anti-Tg antibodies, unstimulated serum thyroglobulin (Tg) levels are generally a reliable marker of recurrent disease, and 18F-FDG positron emission tomography (PET)/computed tomography (CT) plays an important role in the imaging work-up. We report the case of a 65-year-old man evaluated for a large multinodular goitre which caused compressive symptoms; the dominant nodule in the left lobe presented suspicious features on US. Thyroid function showed subclinical hypothyroidism, calcitonin was normal, serum thyroglobulin levels were low, and anti-thyroid antibodies were absent. The prevalent left nodule showed an intense uptake on 18F-FDG PET/CT but proved benign at FNAC. On the basis of the suspicious clinical and imaging features, total thyroidectomy was performed. Histology revealed a tall-cell variant of PTC with scattered expression of Tg and diffuse high expression of cytokeratin (CK) 19; RAI therapy was performed. Within 6 years of surgery, left laterocervical lymph-node recurrence was twice detected (first at levels II and III, then at levels IV and VI) by US and 18F-FDG-PET/CT and was confirmed by FNAC. Tg levels in the washout fluid proved clearly diagnostic of metastasis only in the second, larger, recurrence, whereas serum Tg levels (in the absence of anti-Tg antibodies) always remained undetectable on L-thyroxine therapy. Surgery was performed on both recurrences, and histology confirmed lymph-node metastasis of PTC. Immunohistochemical expression of Tg and CK 19 was similar to that of the primary tumour. No further relapses have occurred to date. Posttherapy (surgery and RAI) unstimulated serum Tg levels may not be a reliable marker of nodal recurrence in patients with differentiated thyroid cancer (DTC) that produces low amounts of Tg.

scholarly journals Application of Pet-CT Fusion Deep Learning Imaging in Precise Radiotherapy of Thyroid Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Qiuyu Lin ◽  
Qianle Qi ◽  
Sen Hou ◽  
Zhen Chen ◽  
Nan Jiang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Sensitivity And Specificity ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Normal Control Group ◽  
Control Group ◽  
Conventional Imaging ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

This article explores the value of wall F-FDG PET/Cr imaging in the diagnosis of thyroid cancer, studies its ability to distinguish benign and malignant thyroid lesions, and seeks ways to improve the accuracy of diagnosis. The normal control group selected 40 patients who came to our center for physical examination. In the normal control group, the average value of the standard uptake value of both sides of the thyroid was used as the SUV of the thyroid gland and the highest SUV value of the patient's lesion (SUV max) represented the SUV of the lesion. After injection of imaging agent 18F-FD1G, routine imaging was performed at 1h, time-lapse imaging was performed at 2.5 h, and the changes with conventional imaging were compared to infer the benign and malignant lesions. We used SPSS software to carry out statistical analysis, respectively, carrying out analysis of variance, paired t-test, independent sample t-test, and linear correlation analysis. In the thyroid cancer group, 87.5% of the delayed imaging SUV was higher than the conventional imaging SUV, while 83.33% of the benign disease group had a lower SUV than the conventional imaging SUV. 18F-FDG PET/CT imaging has higher sensitivity and specificity for the diagnosis of recurrence or metastasis in patients with Tg positive. However, it has lower sensitivity and specificity for the diagnosis of 131I-Dx-WBS negative DTC and 18F-FDG PET/CT. The specificity increases with the increase of serum Tg level. The above results confirm that 18F-FDG PET/CT imaging is of great significance for the diagnosis of recurrence or metastasis in patients; with PET/CT imaging, the results changed 16.13% of the Tg-positive and 131I-Dx-WBS negative DTC patients' later treatment decision. The decision-making and curative effect evaluation have certain value.

scholarly journals 18F-FDG PET/CT imaging findings of multiple solitary fibrous tumor

Medicine ◽  
2019 ◽  
Vol 98 (32) ◽  
pp. e16743
Author(s):  
Xiaofei Liu ◽  
Wenhua Zhu ◽  
Xiaohong Zhou ◽  
Hao Yao ◽  
Jiagui Su ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Imaging Findings ◽  
Pet Ct ◽  
18F Fdg ◽  
Fibrous Tumor ◽  
Fdg Pet Ct

scholarly journals Hibernoma: 18F FDG PET/CT Imaging

2007 ◽  
Vol 2 (6) ◽  
pp. 569-570 ◽  
Author(s):  
Rathan M. Subramaniam ◽  
Amy C. Clayton ◽  
Dimitrios Karantanis ◽  
Douglas A. Collins
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Low positive yield from routine inclusion of the brain in whole-body 18F-FDG PET/CT imaging for noncerebral malignancies

2013 ◽  
Vol 34 (6) ◽  
pp. 540-543 ◽  
Author(s):  
Kuruva Manohar ◽  
Anish Bhattacharya ◽  
Bhagwant R. Mittal
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
The Brain

scholarly journals 18F-FDG PET/CT Imaging In Oncology

2011 ◽  
Vol 31 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Ahmad Almuhaideb ◽  
Nikolaos Papathanasiou ◽  
Jamshed Bomanji
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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