Preliminary study of early response to neoadjuvant chemotherapy after the first cycle in breast cancer: comparison of 1H magnetic resonance spectroscopy with diffusion magnetic resonance imaging

2010 ◽  
Vol 28 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Mitsuhiro Tozaki ◽  
Yu Oyama ◽  
Eisuke Fukuma
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Magnetic Resonance Imaging ◽  
Early Response ◽  
Resonance Spectroscopy ◽  
Resonance Imaging ◽  
1H Magnetic Resonance Spectroscopy ◽  
Preliminary Study ◽  
Response To Neoadjuvant Chemotherapy

scholarly journals Investigation of Fat Metabolism during Antiobesity Interventions by Magnetic Resonance Imaging and Spectroscopy

2014 ◽  
Vol 7 ◽  
pp. MRI.S19362
Author(s):  
Arunima Pola ◽  
Suresh Anand Sadananthan ◽  
Venkatesh Gopalan ◽  
Min-Li Sandra Tan ◽  
Terry Yew Keong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fat Metabolism ◽  
Early Response ◽  
The Body ◽  
Liver Fat ◽  
Resonance Spectroscopy ◽  
Resonance Imaging ◽  
Intramyocellular Lipids ◽  
Fat Depots

The focus of current treatments for obesity is to reduce the body weight or visceral fat, which requires longer duration to show effect. In this study, we investigated the short-term changes in fat metabolism in liver, abdomen, and skeletal muscle during antiobesity interventions including Sibutramine treatment and diet restriction in obese rats using magnetic resonance imaging, magnetic resonance spectroscopy, and blood chemistry. Sibutramine is an antiobesity drug that results in weight loss by increasing satiety and energy expenditure. The Sibutramine-treated rats showed reduction of liver fat and intramyocellular lipids on day 3. The triglycerides (TG) decreased on day 1 and 3 compared to baseline (day 0). The early response/nonresponse in different fat depots will permit optimization of treatment for better clinical outcome rather than staying with a drug for longer periods.

Sign in / Sign up

Export Citation Format

Share Document