Correlation between imaging features and molecular subtypes of breast cancer in young women (≤30 years old)

2020 ◽  
Vol 38 (11) ◽  
pp. 1062-1074
Author(s):  
Junlin Huang ◽  
Qing Lin ◽  
Chunxiao Cui ◽  
Jie Fei ◽  
Xiaohui Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Molecular Subtypes ◽  
Imaging Features

scholarly journals Molecular Subtypes of Breast Cancer: A Review for Breast Radiologists

2020 ◽  
Author(s):  
Karen S Johnson ◽  
Emily F Conant ◽  
Mary Scott Soo
Keyword(s):  
Breast Cancer ◽  
Molecular Subtypes ◽  
Disease Free Survival ◽  
Response To Treatment ◽  
Her2 Status ◽  
Imaging Features ◽  
Luminal A ◽  
Luminal B ◽  
Her2 Breast Cancer ◽  
Er Expression

Abstract Gene expression profiling has reshaped our understanding of breast cancer by identifying four molecular subtypes: (1) luminal A, (2) luminal B, (3) human epidermal growth factor receptor 2 (HER2)-enriched, and (4) basal-like, which have critical differences in incidence, response to treatment, disease progression, survival, and imaging features. Luminal tumors are most common (60%–70%), characterized by estrogen receptor (ER) expression. Luminal A tumors have the best prognosis of all subtypes, whereas patients with luminal B tumors have significantly shorter overall and disease-free survival. Distinguishing between these tumors is important because luminal B tumors require more aggressive treatment. Both commonly present as irregular masses without associated calcifications at mammography; however, luminal B tumors more commonly demonstrate axillary involvement at diagnosis. HER2-enriched tumors are characterized by overexpression of the HER2 oncogene and low-to-absent ER expression. HER2+ disease carries a poor prognosis, but the development of anti-HER2 therapies has greatly improved outcomes for women with HER2+ breast cancer. HER2+ tumors most commonly present as spiculated masses with pleomorphic calcifications or as calcifications alone. Basal-like cancers (15% of all invasive breast cancers) predominate among “triple negative” cancers, which lack ER, progesterone receptor (PR), and HER2 expression. Basal-like cancers are frequently high-grade, large at diagnosis, with high rates of recurrence. Although imaging commonly reveals irregular masses with ill-defined or spiculated margins, some circumscribed basal-like tumors can be mistaken for benign lesions. Incorporating biomarker data (histologic grade, ER/PR/HER2 status, and multigene assays) into classic anatomic TNM staging can better inform clinical management of this heterogeneous disease.

Breast cancer in very young women (<30 years): Correlation of imaging features with clinicopathological features and immunohistochemical subtypes

2015 ◽  
Vol 84 (10) ◽  
pp. 1894-1902 ◽  
Author(s):  
Yeong Yi An ◽  
Sung Hun Kim ◽  
Bong Joo Kang ◽  
Chang Suk Park ◽  
Na Young Jung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Clinicopathological Features ◽  
Imaging Features

Imaging features of automated breast volume scanner: Correlation with molecular subtypes of breast cancer

2017 ◽  
Vol 86 ◽  
pp. 267-275 ◽  
Author(s):  
Feng-Yang Zheng ◽  
Qing Lu ◽  
Bei-Jian Huang ◽  
Han-Sheng Xia ◽  
Li-Xia Yan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Subtypes ◽  
Imaging Features ◽  
Breast Volume ◽  
Automated Breast Volume Scanner

scholarly journals Clinicopathologic Features and Molecular Subtypes of Breast Cancer in Young Women (Age ≤35)

2014 ◽  
Vol 15 (16) ◽  
pp. 6665-6668 ◽  
Author(s):  
Sema Sezgin Goksu ◽  
Didem Tastekin ◽  
Deniz Arslan ◽  
Seyda Gunduz ◽  
Ali Murat Tatli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Molecular Subtypes ◽  
Clinicopathologic Features

scholarly journals Interpreting Genomic Diversity for Breast Cancer: Molecular Subtypes of Breast Cancer in Very Young Women (≤35 Y) in Western Turkey

2013 ◽  
Vol 24 ◽  
pp. iii13
Author(s):  
B. Karaca ◽  
H. Yasdik ◽  
Z. Surmeli ◽  
P. Gursoy ◽  
B. Karabulut ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Molecular Subtypes ◽  
Genomic Diversity ◽  
Western Turkey

scholarly journals Survival following radiotherapy in young women with localized early‐stage breast cancer according to molecular subtypes

2019 ◽  
Vol 8 (6) ◽  
pp. 2840-2857
Author(s):  
Qi‐Qi Liu ◽  
He‐Fen Sun ◽  
Xue‐Li Yang ◽  
Meng‐Ting Chen ◽  
Yang Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Molecular Subtypes ◽  
Early Stage ◽  
Early Stage Breast Cancer

The Impact of Stage and Molecular Subtypes on Survival Outcomes in Young Women with Breast Cancer

2019 ◽  
Vol 8 (5) ◽  
pp. 628-634
Author(s):  
Nisha Hariharan ◽  
T. Subramanyeshwar Rao ◽  
Chandra K. Naidu ◽  
K.V.V.N. Raju ◽  
Senthil Rajappa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Molecular Subtypes ◽  
Survival Outcomes ◽  
The Impact
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