Minimally Invasive Liver Resection for Early-Stage Hepatocellular Carcinoma: Inconsistent Outcomes from Matched or Weighted Cohorts

2019 ◽  
Vol 24 (3) ◽  
pp. 560-568
Author(s):  
Lu Wu ◽  
Diamantis I. Tsilimigras ◽  
Katiuscha Merath ◽  
J. Madison Hyer ◽  
Anghela Z. Paredes ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Minimally Invasive ◽  
Early Stage ◽  
Minimally Invasive Liver Resection

Minimally invasive liver resection for hepatocellular carcinoma of patients with liver damage B: A propensity score-based analysis

2018 ◽  
Vol 48 (7) ◽  
pp. 539-548 ◽  
Author(s):  
Takehiro Noda ◽  
Hidetoshi Eguchi ◽  
Yoshifumi Iwagami ◽  
Daisaku Yamada ◽  
Tadafumi Asaoka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Propensity Score ◽  
Minimally Invasive ◽  
Liver Damage ◽  
Minimally Invasive Liver Resection

scholarly journals Unplanned conversion during minimally invasive liver resection for hepatocellular carcinoma: risk factors and surgical outcomes

2020 ◽  
Vol 98 (1) ◽  
pp. 23
Author(s):  
Jee Yeon Lee ◽  
Seoung Yoon Rho ◽  
Dai Hoon Han ◽  
Jin Sub Choi ◽  
Gi Hong Choi
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Minimally Invasive ◽  
Surgical Outcomes ◽  
Minimally Invasive Liver Resection ◽  
Carcinoma Risk

scholarly journals Oncologic outcome of unplanned conversion during minimally invasive liver resection for hepatocellular carcinoma

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S359-S360
Author(s):  
Seoung Yoon Rho ◽  
Jee Yeon Lee ◽  
Dae Hoon Han ◽  
Jin Sub Choi ◽  
Gi Hong Choi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Minimally Invasive ◽  
Oncologic Outcome ◽  
Minimally Invasive Liver Resection

scholarly journals Safety of intermittent Pringle maneuver during minimally invasive liver resection in patients with hepatocellular carcinoma with and without cirrhosis

2021 ◽  
Author(s):  
Santiago A. Ortiz Galindo ◽  
Philipp K. Haber ◽  
Christian Benzing ◽  
Felix Krenzien ◽  
Anna Riddermann ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Liver Resection ◽  
Minimally Invasive ◽  
Liver Function Tests ◽  
Pringle Maneuver ◽  
Postoperative Outcomes ◽  
Complication Rates ◽  
Minimally Invasive Liver Resection ◽  
The Impact

Abstract Purpose The aim of this study was to analyze the impact of minimally invasive intermittent Pringle maneuver (IPM) on postoperative outcomes in patients with hepatocellular carcinoma (HCC) and liver cirrhosis. Methods In this retrospective cohort study, we evaluated the safety of IPM in patients with HCC who underwent minimally invasive liver resection during five years at our center. Factors influencing the use of IPM were examined in univariate and multivariate regression analysis. Cases with use of IPM (IPM) and those without use of IPM (no IPM) were then compared regarding intraoperative and postoperative outcomes after propensity score matching (PSM) for surgical difficulty. Results One hundred fifty-one patients underwent liver resection for HCC at our center and met inclusion criteria. Of these, 73 patients (48%) received IPM with a median duration of 18 min (5–78). One hundred patients (66%) had confirmed liver cirrhosis. In multivariate analysis, patients with large tumors (≥ 3 cm) and difficult tumor locations (segments VII or VIII) were more likely to undergo IPM (OR 1.176, p = 0.043, and OR 3.243, p = 0.001, respectively). After PSM, there were no differences in intraoperative blood transfusion or postoperative complication rates between the IPM and no IPM groups. Neither did we observe any differences in the subgroup analysis for cirrhotic patients. Postoperative serum liver function tests were not affected by the use of IPM. Conclusions Based on our findings, we conclude that the use of IPM in minimally invasive liver resection is safe and feasible for patients with HCC, including those with compensated liver cirrhosis.

Validity of the Iwate criteria for patients with hepatocellular carcinoma undergoing minimally invasive liver resection

2018 ◽  
Vol 25 (9) ◽  
pp. 403-411 ◽  
Author(s):  
Felix Krenzien ◽  
Simon Wabitsch ◽  
Philipp Haber ◽  
Can Kamali ◽  
Philipp Brunnbauer ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Minimally Invasive ◽  
Minimally Invasive Liver Resection

scholarly journals The Treatment Effect of Liver Transplantation versus Liver Resection for HCC: A Review and Future Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3730
Author(s):  
Berend R. Beumer ◽  
Roeland F. de Wilde ◽  
Herold J. Metselaar ◽  
Robert A. de Man ◽  
Wojciech G. Polak ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Liver Resection ◽  
Early Stage ◽  
Disease Free Survival ◽  
Milan Criteria ◽  
Term Survival ◽  
Equal Distribution ◽  
Intention To Treat ◽  
Treat Analysis

For patients presenting with hepatocellular carcinoma within the Milan criteria, either liver resection or liver transplantation can be performed. However, to what extent either of these treatment options is superior in terms of long-term survival is unknown. Obviously, the comparison of these treatments is complicated by several selection processes. In this article, we comprehensively review the current literature with a focus on factors accounting for selection bias. Thus far, studies that did not perform an intention-to-treat analysis conclude that liver transplantation is superior to liver resection for early-stage hepatocellular carcinoma. In contrast, studies performing an intention-to-treat analysis state that survival is comparable between both modalities. Furthermore, all studies demonstrate that disease-free survival is longer after liver transplantation compared to liver resection. With respect to the latter, implications of recurrences for survival are rarely discussed. Heterogeneous treatment effects and logical inconsistencies indicate that studies with a higher level of evidence are needed to determine if liver transplantation offers a survival benefit over liver resection. However, randomised controlled trials, as the golden standard, are believed to be infeasible. Therefore, we suggest an alternative research design from the causal inference literature. The rationale for a regression discontinuity design that exploits the natural experiment created by the widely adopted Milan criteria will be discussed. In this type of study, the analysis is focused on liver transplantation patients just within the Milan criteria and liver resection patients just outside, hereby ensuring equal distribution of confounders.

scholarly journals Treatments for the early stage Hepatocellular Carcinoma: Laparoscopic Liver Resection or Percutaneous Radiofrequency, How to make the decision?

Liver Cancer ◽  
2021 ◽  
Author(s):  
Jinli Zheng ◽  
Wei Xie ◽  
Yunfeng Zhu ◽  
Li Jiang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Survival Rate ◽  
Liver Resection ◽  
Complication Rate ◽  
Early Stage ◽  
Line Treatment ◽  
Overall Survival Rate ◽  
First Line ◽  
First Line Treatment

Hepatectomy is still as the first-line treatment for the early stage HCC, but the complication rate is higher than p-RFA and the overall survival rate is comparable in these two treatments. Therefore, the patients with small single nodular HCCs could get more benefit from p-RFA, and we need to do further research about p-RFA.

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