Treatment of high fracture risk patients in routine clinical practice

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Olga Lesnyak ◽  
Elena Gladkova ◽  
Nikolay Aleksandrov ◽  
Zhanna Belaya ◽  
Ksenia Belova ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Fracture Risk ◽  
Routine Clinical Practice ◽  
High Fracture ◽  
Risk Patients

scholarly journals Assessment of endogenous fibrinolysis in clinical practice using novel tests: ready for clinical roll-out?

2021 ◽  
Vol 3 (5) ◽  
Author(s):  
Ying X. Gue ◽  
Wern Yew Ding ◽  
Gregory Y. H. Lip ◽  
Diana A. Gorog
Keyword(s):  
Clinical Practice ◽  
Excess Mortality ◽  
Significant Proportion ◽  
Routine Clinical Practice ◽  
Antithrombotic Agents ◽  
Mortality And Morbidity ◽  
Risk Patients ◽  
Thrombotic Complications ◽  
Endogenous Fibrinolysis ◽  
Roll Out

AbstractThe occurrence of thrombotic complications, which can result in excess mortality and morbidity, represent an imbalance between the pro-thrombotic and fibrinolytic equilibrium. The mainstay treatment of these complications involves the use of antithrombotic agents but despite advances in pharmacotherapy, there remains a significant proportion of patients who continue to remain at risk. Endogenous fibrinolysis is a physiological counter-measure against lasting thrombosis and may be measured using several techniques to identify higher risk patients who may benefit from more aggressive pharmacotherapy. However, the assessment of the fibrinolytic system is not yet accepted into routine clinical practice. In this review, we will revisit the different methods of assessing endogenous fibrinolysis (factorial assays, turbidimetric lysis assays, viscoelastic and the global thrombosis tests), including the strengths, limitations, correlation to clinical outcomes of each method and how we might integrate the assessment of endogenous fibrinolysis into clinical practice in the future.

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