scholarly journals The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients

2015 ◽  
Vol 25 (11) ◽  
pp. 2071-2077 ◽  
Author(s):  
Marcus Bandstein ◽  
Bernd Schultes ◽  
Barbara Ernst ◽  
Martin Thurnheer ◽  
Helgi B. Schiöth ◽  
...  
Keyword(s):  
Vitamin D ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Obese Patients ◽  
Loss Effect

scholarly journals Role of Gut-Related Peptides and Other Hormones in the Amelioration of Type 2 Diabetes after Roux-en-Y Gastric Bypass Surgery

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Mirella P. Hage ◽  
Bassem Safadi ◽  
Ibrahim Salti ◽  
Mona Nasrallah
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Cell Function ◽  
Gastric Bypass Surgery ◽  
Gastrointestinal Hormones ◽  
Gut Peptides

Bariatric surgery is currently the most effective and durable therapy for obesity. Roux-en-Y gastric bypass surgery, the most commonly performed procedure worldwide, causes substantial weight loss and improvement in several comorbidities associated with obesity, especially type 2 diabetes. Several mechanisms are proposed to explain the improvement in glucose metabolism after RYGB surgery: the caloric restriction and weight loss per se, the improvement in insulin resistance and beta cell function, and finally the alterations in the various gastrointestinal hormones and adipokines that have been shown to play an important role in glucose homeostasis. However, the timing, exact changes of these hormones, and the relative importance of these changes in the metabolic improvement postbariatric surgery remain to be further clarified. This paper reviews the various changes post-RYGB in adipokines and gut peptides in subjects with T2D.

scholarly journals Association of Circulating Irisin Concentrations with Weight Loss after Roux-en-Y Gastric Bypass Surgery

2019 ◽  
Vol 16 (4) ◽  
pp. 660 ◽  
Author(s):  
Yeon Lee ◽  
Yoonseok Heo ◽  
Ji-Ho Choi ◽  
Sunghyouk Park ◽  
Kyoung Kim ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Excess Weight Loss ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Preoperative Serum ◽  
One Year

Irisin is a myokine with potential anti-obesity properties that has been suggested to increase energy expenditure in obese patients. However, there is limited clinical information on the biology of irisin in humans, especially in morbidly obese patients undergoing bariatric surgery. We aimed to assess the association of circulating irisin concentrations with weight loss in obese patients undergoing bariatric surgery. This was a pilot, single-centre, longitudinal observational study. We recruited 25 morbidly obese subjects who underwent Roux-en-Y gastric bypass surgery (RYGBP), and blood samples from 12 patients were taken to measure serum irisin concentrations before, and one and nine months after surgery. Their clinical characteristics were measured for one year. The preoperative serum irisin concentration (mean 1.01 ± 0.23 μg/mL, range 0.73–1.49) changed bidirectionally one month after RYGBP. The mean concentration at nine months was 1.11 ± 0.15 μg/mL (range 0.92–1.35). Eight patients had elevated irisin levels compared with their preoperative values, but four did not. Elevations of irisin levels nine months, but not one month, after surgery, were associated with lower preoperative levels (p = 0.016) and worse weight reduction rates (p = 0.006 for the percentage excess weight loss and p = 0.032 for changes in body mass index). The preoperative serum irisin concentrations were significantly correlated with the percentage of excess weight loss for one year (R2 = 0.612; p = 0.04) in our study. Our results suggest that preoperative circulating irisin concentrations may be at least in part associated with a weight loss effect of bariatric surgery in morbidly obese patients. Further large-scale clinical studies are needed to ratify these findings.

scholarly journals The Role of the Gut Microbiota in Sustained Weight Loss Following Roux-en-Y Gastric Bypass Surgery

2019 ◽  
Vol 29 (4) ◽  
pp. 1259-1267 ◽  
Author(s):  
Farnaz Fouladi ◽  
Amanda E. Brooks ◽  
Anthony A. Fodor ◽  
Ian M. Carroll ◽  
Emily C. Bulik-Sullivan ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Gut Microbiota ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Sustained Weight Loss

Optimization of Vitamin D Status After Roux-en-Y Gastric Bypass Surgery in Obese Patients Living in Northern Climate

2015 ◽  
Vol 25 (12) ◽  
pp. 2321-2327 ◽  
Author(s):  
Lingtak-Neander Chan ◽  
Charlotte H. Neilson ◽  
Elizabeth A. Kirk ◽  
Tiana F. Colovos ◽  
Diane R. Javelli ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Obese Patients ◽  
Vitamin D Status ◽  
Northern Climate

Prevalence of vitamin D depletion among morbidly obese patients seeking gastric bypass surgery

2005 ◽  
Vol 1 (3) ◽  
pp. 243
Author(s):  
Arthur M. Carlin ◽  
Ali M. Meslemani ◽  
Jeffrey A. Genaw ◽  
Shiri Levy ◽  
Arti Bhan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Vitamin D Depletion

The role of dumping syndrome in weight loss after gastric bypass surgery

2012 ◽  
Vol 27 (5) ◽  
pp. 1573-1578 ◽  
Author(s):  
Ambar Banerjee ◽  
Yi Ding ◽  
Dean J. Mikami ◽  
Bradley J. Needleman
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Dumping Syndrome

scholarly journals Psoriasis remission after gastric bypass surgery: a case report

2014 ◽  
Vol 8 (1) ◽  
pp. 5-10
Author(s):  
Ornella De Pità ◽  
Francesca Lupi ◽  
Giuseppe Cianchini
Keyword(s):  
Morbid Obesity ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Marked Improvement ◽  
Bypass Surgery ◽  
Case Reports ◽  
Gastric Bypass Surgery ◽  
Positive Family History ◽  
Topical Steroids ◽  
Obese Patients

Case reports suggest that gastric bypass surgery in patients with psoriasis may result in complete remission of the disease. A substantial weight loss is achieved in the months following surgery, which is likely to reduce psoriasis symptoms and risk of comorbidities. A 50-year-old man was followed in our Department for several years. He had severe plaque psoriasis requiring superpotent topical steroids and methotrexate. His medical history included morbid obesity (138 kg), dyslipidemia , hypertension and positive family history for psoriasis. He underwent gastric bypass surgery on November 2011. Eight months later, his weight decreased to 86 kg, and he noted a marked improvement in his psoriasis, with reduction of body surface area involvement. In our opinion weight loss may be a useful adjunctive therapy for obese patients with psoriasis.

scholarly journals Effect of bariatric surgery on sulphur amino acids and glutamate

2011 ◽  
Vol 106 (3) ◽  
pp. 432-440 ◽  
Author(s):  
Erlend T. Aasheim ◽  
Amany K. Elshorbagy ◽  
Lien My Diep ◽  
Torgeir T. Søvik ◽  
Tom Mala ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Duodenal Switch ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Obese Patients ◽  
Serum Concentrations ◽  
Total Homocysteine ◽  
Sulphur Amino Acids ◽  
The Relationship

Plasma total cysteine (tCys) concentrations are associated with BMI. To study the relationship between tCys and BMI, we monitored the changes in serum concentrations of tCys and metabolically related compounds in sixty obese patients (BMI 50–60 kg/m2) from before to 1 year after either gastric bypass surgery (mean 30 % weight loss) or duodenal switch surgery (mean 41 % weight loss). A total of fifty-eight healthy persons (BMI 17–31 kg/m2) served as controls. Before surgery, obese patients had modestly (approximately 17 %) higher mean serum tCys, and markedly (>2-fold) higher glutamate concentrations, than controls (P ≤ 0·001 for both). Serial examinations after surgery revealed that gastric bypass patients had no change in tCys concentrations (P = 0·22), while duodenal switch patients showed a modest (approximately 12 %) but significant decrease in tCys (P < 0·001). Total homocysteine concentrations increased in duodenal switch patients but not in gastric bypass patients. Independent of surgery type, serum concentrations of methionine and cystathionine decreased (P < 0·05 for both), while serum glutathione and taurine remained stable. Glutamate concentrations declined, as did γ-glutamyltransferase activity (P < 0·001 for both). These results show that despite 30 % weight loss, and decreases in methionine, cystathionine and glutamate, there was no significant change in serum tCys in patients after gastric bypass surgery. The decrease in tCys in patients undergoing duodenal switch could be related to malabsorption. The present findings do not suggest that BMI is a causal determinant of plasma tCys.

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