scholarly journals New Insights into the Role of Visit-to-Visit Glycemic Variability and Blood Pressure Variability in Cardiovascular Disease Risk

2021 ◽  
Vol 23 (4) ◽  
Author(s):  
Jin J. Zhou ◽  
Daniel S. Nuyujukian ◽  
Peter D. Reaven
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Blood Pressure Variability ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Glycemic Variability

The role of very low birth weight and prematurity on cardiovascular disease risk and on kidney development in children: a pilot study

2020 ◽  
Vol 72 (3) ◽  
Author(s):  
Marco M. Ciccone ◽  
Francesca Cortese ◽  
Michele Gesualdo ◽  
Antonio Di Mauro ◽  
Silvio Tafuri ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Birth Weight ◽  
Pilot Study ◽  
Low Birth Weight ◽  
Kidney Development ◽  
Very Low Birth Weight ◽  
Disease Risk ◽  
Cardiovascular Disease Risk

Role of Childhood Food Patterns on Adult Cardiovascular Disease Risk

2014 ◽  
Vol 16 (10) ◽  
Author(s):  
Jari E. Kaikkonen ◽  
Vera Mikkilä ◽  
Olli T. Raitakari
Keyword(s):  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Food Patterns

scholarly journals Large-Scale Analysis of Apolipoprotein CIII Glycosylation by Ultrahigh Resolution Mass Spectrometry

2021 ◽  
Vol 9 ◽  
Author(s):  
Daniel Demus ◽  
Annemieke Naber ◽  
Viktoria Dotz ◽  
Bas C. Jansen ◽  
Marco R. Bladergroen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Metabolism ◽  
Large Scale ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Sinapinic Acid ◽  
Chemical Oxidation ◽  
Ultrahigh Resolution ◽  
Apolipoprotein Ciii

Apolipoprotein-CIII (apo-CIII) is a glycoprotein involved in lipid metabolism and its levels are associated with cardiovascular disease risk. Apo-CIII sialylation is associated with improved plasma triglyceride levels and its glycosylation may have an effect on the clearance of triglyceride-rich lipoproteins by directing these particles to different metabolic pathways. Large-scale sample cohort studies are required to fully elucidate the role of apo-CIII glycosylation in lipid metabolism and associated cardiovascular disease. In this study, we revisited a high-throughput workflow for the analysis of intact apo-CIII by ultrahigh-resolution MALDI FT-ICR MS. The workflow includes a chemical oxidation step to reduce methionine oxidation heterogeneity and spectrum complexity. Sinapinic acid matrix was used to minimize the loss of sialic acids upon MALDI. MassyTools software was used to standardize and automate MS data processing and quality control. This method was applied on 771 plasma samples from individuals without diabetes allowing for an evaluation of the expression levels of apo-CIII glycoforms against a panel of lipid biomarkers demonstrating the validity of the method. Our study supports the hypothesis that triglyceride clearance may be regulated, or at least strongly influenced by apo-CIII sialylation. Interestingly, the association of apo-CIII glycoforms with triglyceride levels was found to be largely independent of body mass index. Due to its precision and throughput, the new workflow will allow studying the role of apo-CIII in the regulation of lipid metabolism in various disease settings.

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