RACE AND OXIDATIVE STRESS MARKERS DETERMINE BLOOD PRESSURE VARIABILITY IN INDIVIDUALS WITH HIGH CARDIOVASCULAR DISEASE RISK

The transcriptional factor, nuclear factor kappa B (NFkB) plays an important role in the regulation of cytokines. Among the cytokines, tumor necrosis factor-alpha (TNF) plays an important role in cardiovascular pathophysiology. This study was done to determine whether TNF-α blockade with etanercept (ETN) or NFkB blockade with dithiol pyrolidine thiocarbamate (PDTC) attenuate oxidative stress in the paraventricular nucleus (PVN) and contribute to neurohumoral excitation in spontaneously hypertensive rats. Method: Male 20 week old SHR rats were treated with ETN (1 mg/kg BW, sc) or PDTC (100mg/kg BW, ip) for 5 week period. Left ventricular function was measured at baseline (20 weeks) and at 25 weeks using echocardiography. Blood pressure was measured at weekly intervals throughout the study. At the end of the protocol rats were sacrificed the PVN was microdissected for the measurement of cytokines, oxidative stress markers using real time PCR (fold increase compared to WKY controls) and by immunohistochemistry. Superoxide, total reactive oxygen species and peroxynitrite were measured in the PVN and LV using electron paramagnetic resonance. Plasma norepinephrine and epinephrine an indicator of neurohumoral excitation was measured using HPLC-EC. Results: PVN data are tabulated. SHR animals had increased expression of protein and mRNA for cytokines and oxidative stress markers in the PVN and LV with increased MAP and cardiac hypertrophy when compared to WKY rats. Treatment with ETN and PDTC attenuated these increases with PDTC showing marked effect than ETN on hypertrophy and blood pressure responses. Conclusion: These findings suggest that cytokine activation in the PVN contributes to increased oxidative stress and neurohumoral excitation in hypertension.

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Asiatic Acid Decreases Blood Pressure and Oxidative Stress Markers in L-NAME-induced Hypertensive Rats

Khon Kaen University Journal (Graduate Studies) ◽

10.5481/kkujgs.2013.13.3.4 ◽

2013 ◽

Vol 13 (3) ◽

pp. 42-49

Author(s):

Sarawoot Bunbupha ◽

Dr. Poungrat Pakdeechote ◽

Dr. Upa Kukongviriyapan ◽

Dr.Parichat Prachaney

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Asiatic Acid ◽

Oxidative Stress Markers ◽

Hypertensive Rats ◽

Stress Markers ◽

And Oxidative Stress

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Myeloperoxidase: A Useful Biomarker for Cardiovascular Disease Risk Stratification?

Clinical Chemistry ◽

10.1373/clinchem.2009.126029 ◽

2009 ◽

Vol 55 (8) ◽

pp. 1462-1470 ◽

Cited By ~ 148

Author(s):

Roger K Schindhelm ◽

Leonard P van der Zwan ◽

Tom Teerlink ◽

Peter G Scheffer

Keyword(s):

Oxidative Stress ◽

Cardiovascular Disease ◽

Clinical Practice ◽

Risk Stratification ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Routine Clinical Practice ◽

Assay Method ◽

Cvd Risk ◽

And Oxidative Stress

Abstract Background: Inflammation and oxidative stress are associated with atherosclerosis. Myeloperoxidase (MPO) is linked to both inflammation and oxidative stress by its location in leukocytes and its role in catalyzing the formation of oxidizing agents. Recent evidence suggests that MPO activity precipitates atherogenesis. Measurement of MPO in plasma may therefore contribute to cardiovascular disease (CVD) risk stratification. Content: Cross-sectional studies, case-control studies, and prospective-cohort studies investigating the relation between MPO and CVD have been evaluated. Differences in study populations, sample materials, sample handling, and assays were ascertained. Potential causal mechanisms linking MPO to accelerated atherosclerosis are discussed here. A majority of studies indicate that measurement of MPO in plasma was associated with improved CVD risk stratification above and beyond risk stratification results obtained with markers used in routine clinical practice. However, comparison of these epidemiological studies with regard to MPO and outcome is hampered because the reported MPO concentration depends on the assay method, sampling material, and preanalytical and analytical procedures. The link between MPO and CVD can, at least partly, be explained by MPO-dependent oxidation of LDL and HDL, subsequently leading to cholesterol accumulation in the arterial wall. Furthermore, MPO may reduce the bioavailability of nitric oxide, resulting in endothelial dysfunction. Finally, MPO destabilizes atherosclerotic plaques. Summary: Increasing evidence suggests that MPO is causally linked to atherosclerosis and its measurement may improve CVD risk estimation. Before MPO can be used in routine clinical practice, however, standardization of sampling and laboratory procedures is needed.

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Irrational beliefs triggers depression and anxiety symptoms, and increase inflammation and oxidative stress surrogate markers of cardiovascular disease risk; The Attica epidemiological study (2002-2012).

Atherosclerosis ◽

10.1016/j.atherosclerosis.2021.06.138 ◽

2021 ◽

Vol 331 ◽

pp. e48

Author(s):

C. Vassou ◽

E. Georgousopoulou ◽

M. Yannakoulia ◽

C. Chrysohoou ◽

C. Pitsavos ◽

...

Keyword(s):

Oxidative Stress ◽

Cardiovascular Disease ◽

Epidemiological Study ◽

Irrational Beliefs ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Anxiety Symptoms ◽

Surrogate Markers ◽

Depression And Anxiety ◽

And Oxidative Stress

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Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10–18 Years Old

Clinical Chemistry ◽

10.1373/clinchem.2006.073668 ◽

2007 ◽

Vol 53 (3) ◽

pp. 456-464 ◽

Cited By ~ 37

Author(s):

Roya Kelishadi ◽

Mohsen Sharifi ◽

Alireza Khosravi ◽

Khosrow Adeli

Keyword(s):

Oxidative Stress ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Young People ◽

Hdl Cholesterol ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Reactive Protein ◽

Stress Markers ◽

And Oxidative Stress

AbstractBackground: This study was undertaken to determine the association of serum C-reactive protein (CRP) with generalized and abdominal obesity, body fat composition, the metabolic syndrome, and oxidative stress markers among young people.Methods: We conducted a population-based study of 512 young people, aged 10–18 years. We obtained anthropometric and blood pressure measurements. Fasting blood sugar, total cholesterol (TC), HDL-cholesterol, triglycerides, CRP, malondialdehyde (MDA), and conjugated diene (CDE) were quantified. LDL-cholesterol (LDL-C) was calculated for samples with TG ≤4.52 mmol/LResults: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI). In contrast, the mean LDL and TC were higher in underweight than normal weight individuals, and then increased significantly from normal to higher BMI categories. Mean HDL cholesterol significantly decreased with increasing BMI. Overall, CRP, MDA, and CDE were significantly correlated with measures of abdominal obesity. Serum CRP, MDA, and CDE significantly increased in the upper quartiles of waist circumference. Study participants with higher CRP concentrations were more likely to have metabolic syndrome and high oxidative stress markers.Conclusion: We found a significant positive association between CRP and oxidative stress markers in healthy young people, as well as an increase in these markers in the upper quartiles of waist circumference, but not BMI. Oxidative stress and CRP may interact in the early inflammatory processes of atherosclerosis.

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