Management of Hepatitis B in Persons Who Inject Drugs (PWID)

Author(s):  
Shang-Chin Huang ◽  
Jia-Horng Kao
2019 ◽  
Vol 134 (6) ◽  
pp. 651-659 ◽  
Author(s):  
Ruth Koepke ◽  
Danielle N. Sill ◽  
Wajiha Z. Akhtar ◽  
Kailynn P. Mitchell ◽  
Sheila M. Guilfoyle ◽  
...  

Objectives: Despite recommendations for vaccination against hepatitis A virus (HAV) and hepatitis B virus (HBV) for all adults at increased risk of infection, several US states have reported increases in HAV and HBV infections among persons who inject drugs. We investigated hepatitis A and hepatitis B vaccination coverage among a sample of persons who reported injecting drugs and had evidence of hepatitis C virus (HCV) infection. Methods: We searched the Wisconsin Immunization Registry for the vaccination records of persons who underwent HCV testing at syringe services programs from January 1 through August 31, 2018, and were reported to the Wisconsin Division of Public Health as having positive HCV antibody test results and a history of injection drug use. We calculated the percentage of persons who were vaccinated according to national recommendations. Results: Of 215 persons reported, 204 (94.9%) had a client record in the Wisconsin Immunization Registry. Of these 204 persons, 66 (32.4%) had received ≥1 dose of hepatitis A vaccine, 46 (22.5%) had received 2 doses of hepatitis A vaccine, and 115 (56.4%) had received 3 doses of hepatitis B vaccine. Hepatitis B vaccine coverage decreased with increasing age, from 88.0% (22 of 25) among adults aged 20-24 to 30.3% (10 of 33) among adults aged 35-39. Conclusions: These findings suggest that most persons who inject drugs in Wisconsin are susceptible to HAV infection and that most persons aged ≥35 who inject drugs are susceptible to HBV infection. In addition to routine vaccination of children, targeted hepatitis vaccination programs should focus on adults who inject drugs to help prevent future infections.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ainur Mukhatayeva ◽  
Aidana Mustafa ◽  
Natalya Dzissyuk ◽  
Alpamys Issanov ◽  
Bauyrzhan Bayserkin ◽  
...  

AbstractIn contrast with global trends, HIV prevalence in Kazakhstan and other Central Asian countries has been rising in recent years. In this study, we analyzed hepatitis B (HBV), hepatitis C (HCV), tuberculosis (TB) and sexually-transmitted (STI) co-infections among 500 HIV positive study participants recruited from all regions of Kazakhstan. Among our study participants, 27%, 8%, 2%, and 5% were coinfected with, respectively, HCV, TB, HBV, and STI. A considerable proportion of the study participants was also found with triple or quadruple infections of HCV/TB (12%), TB/STI (0.8%), HCV/STI (2%), HCV/HBV (1%), HBV/TB (0.4%), HBV/STI (0.2%), HBV/HCV/TB (0.4%), HBV/HCV/STI (0.2%), or HCV/TB/STI (0.2%). Strong associations were found of certain age groups, duration of HIV infection, and practices of injection drug use and sexual contact with PLWH, with co-infections of HIV/HCV and HIV/TB. The odds of having death was 4.07 times higher with TB/HIV as compared to other co-infections. Co-occurrence of HIV with HCV, HBV, and TB infections among participants of this study highlights the necessity of regular screening for HCV infection among HIV infected patients, together with implementation of vigilant vaccination protocols against HBV and TB. Additionally, persons who inject drugs especially need to be focused for harm reduction efforts that include opiate substitution therapy, needle or syringe exchange programs, regular screening, and increased availability of ART and direct acting antivirals.


1984 ◽  
Vol 48 (4) ◽  
pp. 208-210
Author(s):  
PG Fotos ◽  
RW Miller ◽  
WL Graham ◽  
DC Bowers

1984 ◽  
Vol 48 (10) ◽  
pp. 563-565
Author(s):  
HJ Kwon ◽  
KM Keenan ◽  
H Colman ◽  
KM Sundeen ◽  
DE Waite

1998 ◽  
Vol 139 (1) ◽  
pp. 154-155 ◽  
Author(s):  
Abajo ◽  
Porras-Luque ◽  
Buezo ◽  
Fraga ◽  
DaudEn

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