Regulation of Water-Soluble Phenolic Acid Biosynthesis in Salvia miltiorrhiza Bunge

2013 ◽  
Vol 170 (6) ◽  
pp. 1253-1262 ◽  
Author(s):  
Pengda Ma ◽  
Jingling Liu ◽  
Chenlu Zhang ◽  
Zongsuo Liang
Keyword(s):  
Phenolic Acid ◽  
Salvia Miltiorrhiza ◽  
Water Soluble ◽  
Salvia Miltiorrhiza Bunge ◽  
Acid Biosynthesis

scholarly journals The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Wei Zhou ◽  
Min Shi ◽  
Changping Deng ◽  
Sunjie Lu ◽  
Fenfen Huang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Methyl Jasmonate ◽  
Phenolic Acids ◽  
Phenolic Acid ◽  
Salvia Miltiorrhiza ◽  
Water Soluble ◽  
Biosynthesis Pathway ◽  
Acid Biosynthesis ◽  
Expression Of Genes ◽  
Genes Encoding

AbstractWater-soluble phenolic acids are major bioactive compounds in the medicinal plant species Salvia miltiorrhiza. Phenolic acid biosynthesis is induced by methyl jasmonate (MeJA) in this important Chinese herb. Here, we investigated the mechanism underlying this induction by analyzing a transcriptome library of S. miltiorrhiza in response to MeJA. Global transcriptome analysis identified the MeJA-responsive R2R3-MYB transcription factor-encoding gene SmMYB1. Overexpressing SmMYB1 significantly promoted phenolic acid accumulation and upregulated the expression of genes encoding key enzymes in the phenolic acid biosynthesis pathway, including cytochrome P450-dependent monooxygenase (CYP98A14). Dual-luciferase (dual-LUC) assays and/or an electrophoretic mobility shift assays (EMSAs) indicated that SmMYB1 activated the expression of CYP98A14, as well as the expression of genes encoding anthocyanin biosynthesis pathway enzymes, including chalcone isomerase (CHI) and anthocyanidin synthase (ANS). In addition, SmMYB1 was shown to interact with SmMYC2 to additively promote CYP98A14 expression compared to the action of SmMYB1 alone. Taken together, these results demonstrate that SmMYB1 is an activator that improves the accumulation of phenolic acids and anthocyanins in S. miltiorrhiza. These findings lay the foundation for in-depth studies of the molecular mechanism underlying MeJA-mediated phenolic acid biosynthesis and for the metabolic engineering of bioactive ingredients in S. miltiorrhiza.

The combination of blue and red LED light improves growth and phenolic acid contents in Salvia miltiorrhiza Bunge

2020 ◽  
Vol 158 ◽  
pp. 112959
Author(s):  
Shuncang Zhang ◽  
Jiaqi Ma ◽  
Haiyan Zou ◽  
Lei Zhang ◽  
Suhao Li ◽  
...  
Keyword(s):  
Phenolic Acid ◽  
Salvia Miltiorrhiza ◽  
Salvia Miltiorrhiza Bunge ◽  
Led Light ◽  
Red Led

Tanshinones: An update in the medicinal chemistry in recent 5 years

2020 ◽  
Vol 27 ◽  
Author(s):  
Zhencheng Lai ◽  
Jixiao He ◽  
Changxin Zhou ◽  
Huajun Zhao ◽  
Sunliang Cui
Keyword(s):  
Structural Modification ◽  
Salvia Miltiorrhiza ◽  
Antibacterial Activities ◽  
Water Soluble ◽  
Tanshinone Iia ◽  
Salvia Miltiorrhiza Bunge ◽  
Anticancer Activities ◽  
Sodium Tanshinone Iia Sulfonate ◽  
Antiviral Activities ◽  
Cardioprotective Effects

: Tanshinones is an important type of natural products isolated from Salvia miltiorrhiza Bunge with various bioactivities. Tanshinone IIa, cryptotanshinone and tanshinone I are three kinds of tanshinones which have been widely investigated. Particularly, sodium tanshinone IIa sulfonate is a water-soluble derivative of tanshinone IIa and it is used in clinical in China for treating cardiovascular diseases. In recent years, there are increasing interests for investigation of tanshinones derivatives in various diseases. This article present a review of the anti-atherosclerotic effects, cardioprotective effects, anticancer activities, antibacterial activities and antiviral activities of tanshinones and structural modification work in recent years.

Improving abnormal hemorheological parameters in aging guinea pigs by water-soluble extracts of Salvia miltiorrhiza Bunge

2007 ◽  
Vol 111 (3) ◽  
pp. 483-489 ◽  
Author(s):  
Wen-Chi Hou ◽  
Hsin-Sheng Tsay ◽  
Hong-Jen Liang ◽  
Tzung-Yan Lee ◽  
Guei-Jane Wang ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Salvia Miltiorrhiza ◽  
Water Soluble ◽  
Salvia Miltiorrhiza Bunge

SmMYB111 Is a Key Factor to Phenolic Acid Biosynthesis and Interacts with Both SmTTG1 and SmbHLH51 in Salvia miltiorrhiza

2018 ◽  
Vol 66 (30) ◽  
pp. 8069-8078 ◽  
Author(s):  
Shasha Li ◽  
Yucui Wu ◽  
Jing Kuang ◽  
Huaiqin Wang ◽  
Tangzhi Du ◽  
...  
Keyword(s):  
Phenolic Acid ◽  
Salvia Miltiorrhiza ◽  
Acid Biosynthesis ◽  
Key Factor

scholarly journals Comparative RNA-Sequence Transcriptome Analysis of Phenolic Acid Metabolism in Salvia miltiorrhiza, a Traditional Chinese Medicine Model Plant

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Zhenqiao Song ◽  
Linlin Guo ◽  
Tian Liu ◽  
Caicai Lin ◽  
Jianhua Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Phenolic Acid ◽  
Expression Profiles ◽  
Salvia Miltiorrhiza ◽  
Lignin Biosynthesis ◽  
Biosynthesis Pathway ◽  
Acid Biosynthesis ◽  
The Core ◽  
Phenylpropanoid Biosynthesis

Salvia miltiorrhiza Bunge is an important traditional Chinese medicine (TCM). In this study, two S. miltiorrhiza genotypes (BH18 and ZH23) with different phenolic acid concentrations were used for de novo RNA sequencing (RNA-seq). A total of 170,787 transcripts and 56,216 unigenes were obtained. There were 670 differentially expressed genes (DEGs) identified between BH18 and ZH23, 250 of which were upregulated in ZH23, with genes involved in the phenylpropanoid biosynthesis pathway being the most upregulated genes. Nine genes involved in the lignin biosynthesis pathway were upregulated in BH18 and thus result in higher lignin content in BH18. However, expression profiles of most genes involved in the core common upstream phenylpropanoid biosynthesis pathway were higher in ZH23 than that in BH18. These results indicated that genes involved in the core common upstream phenylpropanoid biosynthesis pathway might play an important role in downstream secondary metabolism and demonstrated that lignin biosynthesis was a putative partially competing pathway with phenolic acid biosynthesis. The results of this study expanded our understanding of the regulation of phenolic acid biosynthesis in S. miltiorrhiza.

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