Employing Central Composite Design for Evaluation of Biomass Production by Fusarium venenatum: In Vivo Antioxidant and Antihyperlipidemic Properties

2017 ◽  
Vol 183 (1) ◽  
pp. 91-109 ◽  
Author(s):  
Asha Byju Thomas ◽  
Trupti Dattatray Shetane ◽  
Ranu Goutam Singha ◽  
Rabindra K. Nanda ◽  
Sushilkumar S. Poddar ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Biomass Production ◽  
Fusarium Venenatum ◽  
Central Composite

Optimization of Chronomodulated Delivery System Coated with a Blend of Ethyl Cellulose and Eudragit L100 by Central Composite Design: In Vitro and In Vivo Evaluation

2014 ◽  
Vol 9 (2) ◽  
pp. 95-105 ◽  
Author(s):  
Om Prakash Ranjan ◽  
Usha Y. Nayak ◽  
M. Sreenivasa Reddy ◽  
Swapnil J. Dengale ◽  
Prashant B. Musmade ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Delivery System ◽  
Ethyl Cellulose ◽  
In Vivo Evaluation ◽  
Eudragit L100 ◽  
Central Composite

scholarly journals Plackett-Burman matrix and response surface methodology-central composite design for optimization of Lactobacillus Acidophilus biomass production

2014 ◽  
Vol 17 (2) ◽  
pp. 60-72
Author(s):  
Huong Huynh Lien Ly ◽  
Huong Thuy Nguyen
Keyword(s):  
Response Surface Methodology ◽  
Central Composite Design ◽  
Response Surface ◽  
Biomass Production ◽  
Lactobacillus Acidophilus ◽  
Initial Density ◽  
Optimization Theory ◽  
Similar Proportion ◽  
Maximum Value ◽  
Central Composite

Biomass of Lactobacillus acidophilus was optimized in the tofu wastewater medium by Plackett-Burman matrix and Response surface methodology – Central composite design (RSM-CCD). The highest biomass was 0.73 g/100mL at 106 CFU/mL of initial density of L. acidophilus in tofu wastewater medium, with 0.37% (NH4)2SO4 and 17.59% sucrose. L. acidophilus produced maximum value of biomass after 20 hours of incubation at 37°C. There was a similar proportion at 96.05% in comparison to experimental value and optimization theory, approximatly 93.58% L. acidophilus biomass in MRS medium. As a result, optimization model could be applied in biomass production of L. acidophilus to enhance comercial value and contribute to environmental protection.

In vivo evaluation of pH and time-dependent polymers as coating agent for colonic delivery using central composite design

2018 ◽  
Vol 43 ◽  
pp. 50-56 ◽  
Author(s):  
Eskandar Moghimipour ◽  
Farid Abedin Dorkoosh ◽  
Mohsen Rezaei ◽  
Maryam Kouchak ◽  
Jafar Fatahiasl ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Time Dependent ◽  
Colonic Delivery ◽  
In Vivo Evaluation ◽  
Coating Agent ◽  
Central Composite

Development and Optimization of Atorvastatin Calcium-Cyclodextrin Inclusion Complexed Orally-Disintegrating Tablets with Enhanced Pharmacokinetic and Pharmaco-dynamic Profile

1970 ◽  
Vol 9 (2) ◽  
pp. 3170-3180
Author(s):  
Palem Chinna Reddy ◽  
Narendar Reddy Dudhipala ◽  
Satyanarayana Goda ◽  
Varsha B. Pokharkar
Keyword(s):  
Central Composite Design ◽  
Dissolution Rate ◽  
In Vivo Studies ◽  
Drying Methods ◽  
Phase Solubility ◽  
Dissolution Profile ◽  
Atorvastatin Calcium ◽  
Central Composite ◽  
Spray Dried

The content of the investigation was to study the influence of hydroxy propyl-b-cyclodextrin (HPβCD) complexed oral disintegrating tablets (ODTs) on enhancement of solubility, dissolution rate, pharmacodynamic activity and bioavailability of atorvastatin calcium (AT) by central composite design. Based on preliminary phase solubility studies, solubility was linearly increased and followed AL-type profile. Solid complexes were prepared by physical mixing, kneading, freeze and spray drying methods. Spray-dried product showed higher solubility and dissolution rate than other complexes. Amount of drug (X1), amount of HPβCD (X2) and amount of supradisintegrant (X3) as independent and solubility (Y1), disintegration time (Y2) and percent drug release in 15 min (Q15, Y3) as dependent responses. Drug- HPβCD complex formation was confirmed by FTIR, DSC and XRD. AT-HPβCD ODTs were developed and evaluated for physico-chemical properties, stability and dissolution rate. Further, in vivo pharmacokinetic and pharmacodynamic studies were performed in rat model. The statistically optimized formulation showed 0.817 ± 0.06 mg/ml of solubility, 54 ± 2 sec of DT and 69 ± 2.4 % of Q15. The physical stability was studied for 6 months. No significant changes were detected in dissolution profile and drug content of tablets after 6 months during the stability studies. The in vivo studies of spray dried complexed tablets compared to AT in rats revealed that 3.3-folds improvement in oral bioavailability and there was significant reduction (p<0.01) in cholesterol and triglyceride levels and significant improvement (p<0.01) in HDL level. The results conclusively demonstrated that the AT-HPbCD-ODT could be prepared with improved solubility and hypolipidemic activity by using central composite design.

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