Three Levels Face Centered Central Composite Design of Colon Targeted Micro-Particulates System of Celecoxib: Screening of Formulations Variables and in vivo Studies

2014 ◽  
Vol 11 (5) ◽  
pp. 621-635 ◽  
Author(s):  
Bankim Nandy ◽  
Vinod Verma ◽  
Sanjay Dey ◽  
Bhaskar Mazumder
Keyword(s):  
Central Composite Design ◽  
In Vivo Studies ◽  
Face Centered ◽  
Central Composite

Development and Optimization of Atorvastatin Calcium-Cyclodextrin Inclusion Complexed Orally-Disintegrating Tablets with Enhanced Pharmacokinetic and Pharmaco-dynamic Profile

1970 ◽  
Vol 9 (2) ◽  
pp. 3170-3180
Author(s):  
Palem Chinna Reddy ◽  
Narendar Reddy Dudhipala ◽  
Satyanarayana Goda ◽  
Varsha B. Pokharkar
Keyword(s):  
Central Composite Design ◽  
Dissolution Rate ◽  
In Vivo Studies ◽  
Drying Methods ◽  
Phase Solubility ◽  
Dissolution Profile ◽  
Atorvastatin Calcium ◽  
Central Composite ◽  
Spray Dried

The content of the investigation was to study the influence of hydroxy propyl-b-cyclodextrin (HPβCD) complexed oral disintegrating tablets (ODTs) on enhancement of solubility, dissolution rate, pharmacodynamic activity and bioavailability of atorvastatin calcium (AT) by central composite design. Based on preliminary phase solubility studies, solubility was linearly increased and followed AL-type profile. Solid complexes were prepared by physical mixing, kneading, freeze and spray drying methods. Spray-dried product showed higher solubility and dissolution rate than other complexes. Amount of drug (X1), amount of HPβCD (X2) and amount of supradisintegrant (X3) as independent and solubility (Y1), disintegration time (Y2) and percent drug release in 15 min (Q15, Y3) as dependent responses. Drug- HPβCD complex formation was confirmed by FTIR, DSC and XRD. AT-HPβCD ODTs were developed and evaluated for physico-chemical properties, stability and dissolution rate. Further, in vivo pharmacokinetic and pharmacodynamic studies were performed in rat model. The statistically optimized formulation showed 0.817 ± 0.06 mg/ml of solubility, 54 ± 2 sec of DT and 69 ± 2.4 % of Q15. The physical stability was studied for 6 months. No significant changes were detected in dissolution profile and drug content of tablets after 6 months during the stability studies. The in vivo studies of spray dried complexed tablets compared to AT in rats revealed that 3.3-folds improvement in oral bioavailability and there was significant reduction (p<0.01) in cholesterol and triglyceride levels and significant improvement (p<0.01) in HDL level. The results conclusively demonstrated that the AT-HPbCD-ODT could be prepared with improved solubility and hypolipidemic activity by using central composite design.

Optimization of Chronomodulated Delivery System Coated with a Blend of Ethyl Cellulose and Eudragit L100 by Central Composite Design: In Vitro and In Vivo Evaluation

2014 ◽  
Vol 9 (2) ◽  
pp. 95-105 ◽  
Author(s):  
Om Prakash Ranjan ◽  
Usha Y. Nayak ◽  
M. Sreenivasa Reddy ◽  
Swapnil J. Dengale ◽  
Prashant B. Musmade ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Delivery System ◽  
Ethyl Cellulose ◽  
In Vivo Evaluation ◽  
Eudragit L100 ◽  
Central Composite

Which is better for optimizing the biosorption process of lead – central composite design or the Taguchi technique?

2016 ◽  
Vol 74 (6) ◽  
pp. 1446-1456 ◽  
Author(s):  
Ali Azari ◽  
Alireza Mesdaghinia ◽  
Ghader Ghanizadeh ◽  
Hossein Masoumbeigi ◽  
Meghdad Pirsaheb ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Removal Efficiency ◽  
Chemical Engineering ◽  
Three Dimensional ◽  
Taguchi Technique ◽  
Biosorption Process ◽  
Contour Plots ◽  
Face Centered ◽  
Central Composite ◽  
Experimental Runs

The aim of this study is to evaluate central composite design (CCD) and the Taguchi technique in the adsorption process. Contact time, initial concentration, and pH were selected as the variables, and the removal efficiency of Pb was chosen for the designated response. In addition, face-centered CCD and the L9 orthogonal array were used for the experimental design. The result indicated that, at optimum conditions, the removal efficiency of Pb was 80%. However, the value of R2 was greater than 0.95 for both the CCD and Taguchi techniques, which revealed that both techniques were suitable and in conformity with each other. Moreover, the results of analysis of variance and Prob &gt; F &lt; 0.05 showed the appropriate fit of the designated model with the experimental results. The probability of classifying the contributing variables by giving a percentage of the response quantity (Pb removal) made the Taguchi model an appropriate method for examining the effectiveness of different factors. pH was evaluated as the best input factor as it contributed 66.2% of Pb removal. The Taguchi technique was additionally confirmed by three-dimensional contour plots of CCD. Consequently, the Taguchi method with nine experimental runs and easy interaction plots is an appropriate substitute for CCD for several chemical engineering functions.

Development of novel pH-sensitive nanoparticle-based transdermal patch for management of rheumatoid arthritis

Nanomedicine ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. 603-624 ◽  
Author(s):  
Dildar Khan ◽  
Maimoona Qindeel ◽  
Naveed Ahmed ◽  
Ashraf U Khan ◽  
Salman Khan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Transdermal Delivery ◽  
Therapeutic Potential ◽  
Ph Sensitive ◽  
In Vivo Studies ◽  
Transdermal Patch ◽  
Inflammatory Models ◽  
Average Size ◽  
Central Composite

Aim: To formulate and evaluate a pH-responsive nanoparticle (NP)-based patch for efficient transdermal delivery of flurbiprofen against rheumatoid arthritis. Materials & methods: Nanoprecipitation technique was used for preparation of NPs and central composite design was employed for optimization purposes. Optimized NPs were loaded into the transdermal patch by the solvent evaporation method. Results: Prepared NPs exhibited an average size of 69 nm, while NPs loaded onto the transdermal patch showed sustained release and high permeation through the skin. In in vivo studies, the prepared carrier system elucidated high therapeutic potential in both acute and chronic inflammatory models as evident from the results of behavioral, radiological, histopathological and antioxidant analyses. Conclusion: The flurbiprofen-loaded pH-sensitive NP-based transdermal patch has the potential to manage rheumatoid arthritis effectively.

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