Myeloperoxidase Activity and Its Corresponding mRNA Expression as well as Gene Polymorphism in the Population Living in the Coal-Burning Endemic Fluorosis Area in Guizhou of China

2013 ◽  
Vol 152 (3) ◽  
pp. 379-386 ◽  
Author(s):  
Ting Zhang ◽  
Ke-Ren Shan ◽  
Xi Tu ◽  
Yan He ◽  
Jin-Jing Pei ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Mrna Expression ◽  
Myeloperoxidase Activity ◽  
Endemic Fluorosis ◽  
Coal Burning

Epidemic Status of Coal-burning Type of Endemic Fluorosis

2021 ◽  
pp. 13-27
Author(s):  
Zhi-Zhong Guan ◽  
Fu-Cheng Li ◽  
Yi Zhao ◽  
Chang-Xue Wu
Keyword(s):  
Endemic Fluorosis ◽  
Coal Burning

Cyp1B1 mRNA expression in correlation to cotinine levels with respect to the Cyp1B1 L432V gene polymorphism

2010 ◽  
Vol 25 (12) ◽  
pp. 867-873 ◽  
Author(s):  
Simone Helmig ◽  
Jens Udo Seelinger ◽  
Monika Philipp-Gehlhaar ◽  
Juliane Döhrel ◽  
Joachim Schneider
Keyword(s):  
Gene Polymorphism ◽  
Mrna Expression ◽  
Cyp1b1 Mrna

Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo

2000 ◽  
Vol 278 (5) ◽  
pp. L914-L922 ◽  
Author(s):  
Toru Arai ◽  
Kin'Ya Abe ◽  
Hiroto Matsuoka ◽  
Mitsuhiro Yoshida ◽  
Masahide Mori ◽  
...  
Keyword(s):  
Growth Factor ◽  
Lung Injury ◽  
Bronchoalveolar Lavage ◽  
Mrna Expression ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Type I ◽  
Myeloperoxidase Activity ◽  
Human Lung Fibroblast

Interleukin (IL)-10 has been shown to reduce many inflammatory reactions. We investigated the in vivo effects of IL-10 on a bleomycin-induced lung injury model. Hemagglutinating virus of Japan (HVJ)-liposomes containing a human IL-10 expression vector (hIL10-HVJ) or a balanced salt solution as a control (Cont-HVJ) was intraperitoneally injected into mice on day −3. This was followed by intratracheal instillation of bleomycin (0.8 mg/kg) on day 0. Myeloperoxidase activity of bronchoalveolar lavage fluid and tumor necrosis factor-α mRNA expression in bronchoalveolar lavage fluid cells on day 7 and hydroxyproline content of the whole lung on day 21 were inhibited significantly by hIL10-HVJ treatment. However, Cont-HVJ treatment could not suppress any of these parameters. We also examined the in vitro effects of IL-10 on the human lung fibroblast cell line WI-38. IL-10 significantly reduced constitutive and transforming growth factor-β-stimulated type I collagen mRNA expression. However, IL-10 did not affect the proliferation of WI-38 cells induced by platelet-derived growth factor. These data suggested that exogenous IL-10 may be useful in the treatment of pulmonary fibrosis.

scholarly journals Protective Effect ofFlos Loniceraeagainst Experimental Gastric Ulcers in Rats: Mechanisms of Antioxidant and Anti-Inflammatory Action

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jung-Woo Kang ◽  
Nari Yun ◽  
Hae-Jung Han ◽  
Jeom-Yong Kim ◽  
Joo-Young Kim ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Acetic Acid ◽  
Gastric Ulcer ◽  
Mrna Expression ◽  
Inflammatory Cytokines ◽  
Gastric Wall ◽  
Myeloperoxidase Activity ◽  
Flos Lonicerae ◽  
Anti Inflammatory

Flos Loniceraeis one of the oldest and most commonly prescribed herbs in Eastern traditional medicine to treat various inflammatory diseases. In the present study, we investigated the effects of ethyl acetate fraction ofFlos Lonicerae(GC-7101) on experimental gastric ulcer models and its mechanisms of action in gastric ulcer healing. The pharmacological activity of GC-7101 was investigated in rats on HCl/EtOH, indomethacin, water immersion restraint stress induced acute gastric ulcer, and acetic-acid-induced subchronic gastric ulcer. To determine its gastroprotective mechanisms, gastric wall mucus secretion, mucosal PGE2, mucosal NO content, nuclear translocation of NF-κB, mRNA expression of inflammatory cytokines, lipid peroxidation and glutathione content, and superoxide dismutase and catalase activities were measured. GC-7101 significantly attenuated development of acute gastric ulcer and accelerated the healing of acetic-acid-induced subchronic gastric ulcer. In HCl/EtOH-induced gastric ulcer, GC-7101 markedly enhanced gastric wall mucus content which was accompanied by increased mucosal PGE2and NO production. Furthermore, treatment of GC-7101 exhibited anti-inflammatory and antioxidant activities as evidenced by decreased myeloperoxidase activity, NF-κB translocation, inflammatory cytokines mRNA expression, and lipid peroxidation and increased glutathione content and superoxide dismutase and catalase activities. These results demonstrated that GC-7101 possesses strong antiulcerogenic effect by modulating oxidative stress and proinflammatory mediators.

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