Ru(II)-Based Amino Acid Complexes Show Promise for Leukemia Treatment: Cytotoxicity and Some Light on their Mechanism of Action

2019 ◽  
Vol 197 (1) ◽  
pp. 123-131
Author(s):  
Aliny Pereira de Lima ◽  
Marcio Aurélio Pinheiro Almeida ◽  
Francyelli Mello-Andrade ◽  
Flávia de Castro Pereira ◽  
Wanessa Carvalho Pires ◽  
...  
Keyword(s):  
Amino Acid ◽  
Mechanism Of Action ◽  
Amino Acid Complexes ◽  
Leukemia Treatment

Amino acid-induced impairment of glucose oxidation by isolated rat muscle: mechanism of action

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
K Stadlbauer ◽  
B Brunmair ◽  
Z Szöcs ◽  
M Krebs ◽  
A Luger ◽  
...  
Keyword(s):  
Amino Acid ◽  
Mechanism Of Action ◽  
Glucose Oxidation ◽  
Rat Muscle ◽  
Isolated Rat

The minimal amino acid sequence of the insulin-potentiating fragments of human growth hormone: its mechanism of action

Diabetes ◽  
1980 ◽  
Vol 29 (10) ◽  
pp. 782-787 ◽  
Author(s):  
F. M. Ng ◽  
J. Bornstein ◽  
C. E. Pullin ◽  
J. O. Bromley ◽  
S. L. Macaulay
Keyword(s):  
Growth Hormone ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Human Growth Hormone ◽  
Mechanism Of Action ◽  
Human Growth

Potentiometric study of enantioselective effects in α-amino acid complexes of copper(II)

1985 ◽  
Vol 104 (1) ◽  
pp. 63-67 ◽  
Author(s):  
I.L. Ulanovski ◽  
A.A. Kurganov ◽  
V.A. Davankov
Keyword(s):  
Amino Acid ◽  
Potentiometric Study ◽  
Amino Acid Complexes

scholarly journals Studies on the Mechanism of Action of d-Amino Acid Oxidase

1971 ◽  
Vol 246 (22) ◽  
pp. 6855-6866 ◽  
Author(s):  
Christopher T. Walsh ◽  
Agnes Schonbrunn ◽  
Robert H. Abeles
Keyword(s):  
Amino Acid ◽  
Mechanism Of Action ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

scholarly journals Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 421
Author(s):  
Areetha R. D’Souza ◽  
Matthew R. Necelis ◽  
Alona Kulesha ◽  
Gregory A. Caputo ◽  
Olga V. Makhlynets
Keyword(s):  
Amino Acid ◽  
Antimicrobial Peptides ◽  
Antimicrobial Peptide ◽  
Mechanism Of Action ◽  
Bactericidal Activity ◽  
Antimicrobial Agents ◽  
Human Cells ◽  
Side Chains ◽  
Natural Amino Acid ◽  
Proteolytic Stability

Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using unique properties of this amino acid, such as ability to be excited separately from tryptophan in a multi-Trp AMPs and environmental insensitivity. In this work, we investigate the effect of Trp→AzAla substitution in antimicrobial peptide buCATHL4B (contains three Trp side chains). We found that antimicrobial and bactericidal activity of the original peptide was preserved, while cytocompatibility with human cells and proteolytic stability was improved. We envision that AzAla will find applications as a tool for studies of the mechanism of action of AMPs. In addition, incorporation of this non-natural amino acid into AMP sequences could enhance their application properties.

scholarly journals Synthesis, Characterization, and Non-Covalent Interactions of Palladium(II)-Amino Acid Complexes

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4331
Author(s):  
David B. Hobart ◽  
Michael A. G. Berg ◽  
Hannah M. Rogers ◽  
Joseph S. Merola
Keyword(s):  
Amino Acid ◽  
High Resolution Mass Spectrometry ◽  
Resonance Spectroscopy ◽  
Spectroscopic Techniques ◽  
X Ray Diffraction ◽  
Amino Acid Complexes ◽  
Acetone Water ◽  
Square Planar ◽  
Non Covalent Interactions ◽  
Covalent Interactions

The reaction of palladium(II) acetate with acyclic amino acids in acetone/water yields square planar bis-chelated palladium amino acid complexes that exhibit interesting non-covalent interactions. In all cases, complexes were examined by multiple spectroscopic techniques, especially HRMS (high resolution mass spectrometry), IR (infrared spectroscopy), and 1H NMR (nuclear magnetic resonance) spectroscopy. In some cases, suitable crystals for single crystal X-ray diffraction were able to be grown and the molecular structure was obtained. The molecular geometries of the products are discussed. Except for the alanine complex, all complexes incorporate water molecules into the extended lattice and exhibit N-H···O and/or O···(HOH)···O hydrogen bonding interactions. The non-covalent interactions are discussed in terms of the extended lattice structures exhibited by the structures.

Ternary chromium(III)-nucleotide-amino acid complexes III. L-Glutamic acid derivatives

1989 ◽  
Vol 165 (1) ◽  
pp. 131-137 ◽  
Author(s):  
M. Vicens ◽  
J.J. Fiol ◽  
A. Terron ◽  
V. Moreno
Keyword(s):  
Amino Acid ◽  
Glutamic Acid ◽  
Amino Acid Complexes ◽  
Glutamic Acid Derivatives

Equilibrium constants of metal amino acid complexes

Polyhedron ◽  
1990 ◽  
Vol 9 (5) ◽  
pp. 665-668 ◽  
Author(s):  
F. Rey ◽  
J.M. Antelo ◽  
F. Arce ◽  
F.J. Penedo
Keyword(s):  
Amino Acid ◽  
Equilibrium Constants ◽  
Amino Acid Complexes

Synthesis and properties of Zn(II)-salicylidene amino acid complexes

1987 ◽  
Vol 118 (11) ◽  
pp. 1289-1296 ◽  
Author(s):  
M. R. Mahmoud ◽  
S. A. El-Gyar ◽  
A. Shaker ◽  
A. M. Abdel-Mawgoud
Keyword(s):  
Amino Acid ◽  
Amino Acid Complexes
Sign in / Sign up

Export Citation Format

Share Document