Low 25 (OH) vitamin D levels are associated with autoimmune thyroid disease in polycystic ovary syndrome

Endocrine ◽  
2015 ◽  
Vol 53 (2) ◽  
pp. 538-542 ◽  
Author(s):  
Giovanna Muscogiuri ◽  
Stefano Palomba ◽  
Mario Caggiano ◽  
Domenico Tafuri ◽  
Annamaria Colao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Autoimmune Thyroid ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Frequency of nodular goiter and autoimmune thyroid disease in patients with polycystic ovary syndrome

Endocrine ◽  
2014 ◽  
Vol 49 (2) ◽  
pp. 464-469 ◽  
Author(s):  
Cevdet Duran ◽  
Mustafa Basaran ◽  
Orkide Kutlu ◽  
Zehra Kucukaydin ◽  
Suleyman Bakdik ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Polycystic Ovary ◽  
Nodular Goiter ◽  
Ovary Syndrome ◽  
Autoimmune Thyroid

Dehydroepiandrosterone Sulfate Level is Lower in Polycystic Ovary Syndrome Patients with Autoimmune Thyroid Disease

2015 ◽  
Vol 10 (2) ◽  
pp. 47-52
Author(s):  
Aslı DOĞRUK ÜNAL ◽  
Özlem TARÇIN ◽  
Özlem CİĞERLİ ◽  
Hülya PARILDAR ◽  
Betül UĞUR ALTUN ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Polycystic Ovary ◽  
Dehydroepiandrosterone Sulfate ◽  
Ovary Syndrome ◽  
Autoimmune Thyroid

scholarly journals Increased Risk of Polycystic Ovary Syndrome and It’s Comorbidities in Women with Autoimmune Thyroid Disease

2020 ◽  
Vol 17 (7) ◽  
pp. 2422
Author(s):  
Chun-Wei Ho ◽  
Hsin-Hung Chen ◽  
Ming-Chia Hsieh ◽  
Ching-Chu Chen ◽  
Sheng-Pang Hsu ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Polycystic Ovary ◽  
Group Method ◽  
Control Group ◽  
Ovary Syndrome ◽  
Autoimmune Thyroid ◽  
Increased Risk ◽  
Artery Disease

Objective: To investigate the prevalence of polycystic ovary syndrome (PCOS) and its comorbidities in patients with autoimmune thyroid disease (AITD). Population: In this cohort study, patients newly diagnosed as having Hashimoto thyroiditis (HT) or Grave disease (GD) were recruited into the AITD group. Method: The logistic regression model was used to investigate the association between exposure, endpoint, later diseases and treatment. Main Outcome Measures: We assessed the cumulative incidence using the Kaplan–Meier method and verified the difference by the log-rank test. Results: The AITD group included 3599 GD patients and 1332 HT patients. PCOS risk in patients with AITD was higher than that in the control group (adjusted hazard ratio = 1.39; 95% confidence interval = 1.07–1.71). In patients with both AITD and PCOS, the odds ratios of diabetes, hyperlipidemia and coronary artery disease were 2.48, 2.05 and 2.63, respectively. Conclusions: The risks of PCOS and its comorbidities such as diabetes, dyslipidemia and cardiac artery disease are high in patients with AITD in Taiwan.

scholarly journals Decreased serum level of gamma-amino butyric acid in Egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25(OH) vitamin D levels

2019 ◽  
Vol 38 (4) ◽  
pp. 512-518 ◽  
Author(s):  
Rasha A. Radwan ◽  
Nermeen Z. Abuelezz ◽  
Sahar M. Abdelraouf ◽  
Engy M. Bakeer ◽  
Abdullah A. Abd El Rahman
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Total Testosterone ◽  
Endocrine Disorders ◽  
Gamma Aminobutyric Acid ◽  
Gaba Level ◽  
Ovary Syndrome ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

SummaryBackgroundPolycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders around the world. Increasing evidence suggests that neurotransmitter Gamma-aminobutyric acid (GABA) is involved in the pathogenesis of PCOS through its central role in the hypothalamus. However, the peripheral role of GABA in PCOS has not been sufficiently investigated in spite of its existence in peripheral organs. First, the aim of this study is to, investigate serum GABA level in Egyptian PCOS patients. Second, to explore the correlation between serum GABA level with Body Mass Index (BMI), dyslipidemia, totaltestosterone and 25 (OH) vitamin D.MethodsEighty PCOS patients and eighty age-matched healthy females were included in this study. All parameters were assessed colourimetrically or with ELISA.ResultsPCOS patients exhibited significantly decreased serum GABA level compared to controls (p < 0.001). There was a significant positive correlation between serum GABA and 25(OH) vitamin D levels (r = 0.26, p = 0.018), and a significant negative correlation with total testosterone (r = - 0.3, p = 0.02), total cholesterol (TC) (r = - 0.31, p = 0.01) and LDL-Cholesterol (LDL-C) (r = - 0.23, p = 0.045), respectively.ConclusionsThe findings of this study suggest that disrupted GABA level in the peripheral circulation is an additional contributing factor to PCOS manifestations. GABA deficiency was correlated with 25 (OH) vitamin D deficiency, dyslipidemia, and total testosterone. Further investigations for GABA adjustment might provide a promising means for better management of PCOS symptoms.

scholarly journals Associations between vitamin D levels and polycystic ovary syndrome phenotypes

2019 ◽  
Vol 44 (2) ◽  
Author(s):  
Erin M. Davis ◽  
Jennifer D. Peck ◽  
Karl R. Hansen ◽  
Barbara R. Neas ◽  
LaTasha B. Craig
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Vitamin D Levels

scholarly journals Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

2021 ◽  
Vol 8 ◽  
Author(s):  
Iman Abdullah Bindayel
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Triglyceride ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Hydroxyvitamin D ◽  
Saudi Women ◽  
Number Of Patients ◽  
Vitamin D Levels

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. In this study, serum 25-hydroxyvitamin D levels were compared between women with and without PCOS and with regard to anthropometric indices and lipid and glucose biomarkers. Thirty-one women with PCOS and 75 controls answered a questionnaire on vitamin D, in addition to general health and lifestyle. The patients with PCOS had lower vitamin D levels (p &lt; 0.05), a significantly higher rate of obesity (p &lt; 0.05), and significantly higher serum triglyceride levels than did controls. The number of patients with PCOS consumed milk and dairy products (p &lt; 0.05) and exposed to sun (p &lt; 0.006) were lower compared to controls. Triglyceride levels were significantly correlated with body mass index (BMI); vitamin D level was not significantly correlated with anthropometrical or biochemical variables. These results affirm that vitamin D levels are lower in women with PCOS; however, despite the significantly higher proportion of obesity among patients with PCOS, hypovitaminosis was not associated with BMI. The relationship between body composition and vitamin D in PCOS and the effect of vitamin D correction on metabolic and hormonal parameters associated with PCOS must be assessed in future trials.

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