scholarly journals Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome

2021 ◽  
Vol 8 ◽  
Author(s):  
Iman Abdullah Bindayel
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Triglyceride ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Hydroxyvitamin D ◽  
Saudi Women ◽  
Number Of Patients ◽  
Vitamin D Levels

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. In this study, serum 25-hydroxyvitamin D levels were compared between women with and without PCOS and with regard to anthropometric indices and lipid and glucose biomarkers. Thirty-one women with PCOS and 75 controls answered a questionnaire on vitamin D, in addition to general health and lifestyle. The patients with PCOS had lower vitamin D levels (p < 0.05), a significantly higher rate of obesity (p < 0.05), and significantly higher serum triglyceride levels than did controls. The number of patients with PCOS consumed milk and dairy products (p < 0.05) and exposed to sun (p < 0.006) were lower compared to controls. Triglyceride levels were significantly correlated with body mass index (BMI); vitamin D level was not significantly correlated with anthropometrical or biochemical variables. These results affirm that vitamin D levels are lower in women with PCOS; however, despite the significantly higher proportion of obesity among patients with PCOS, hypovitaminosis was not associated with BMI. The relationship between body composition and vitamin D in PCOS and the effect of vitamin D correction on metabolic and hormonal parameters associated with PCOS must be assessed in future trials.

scholarly journals MON-037 Vitamin D Levels in Women with Polycystic Ovary Syndrome: Influence of Obesity

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Patricia Nieves Amelia Maidana ◽  
Gladys Isabel Fernández ◽  
Analy Fritzler ◽  
María Gabriela Ropelato ◽  
Lamas-Majek Eugenia ◽  
...  
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Fat Distribution ◽  
Normal Weight ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Metabolic Complications ◽  
Negatively Associated ◽  
Vitamin D Levels

Abstract Introduction: Polycystic ovary syndrome (PCOS) is the most frequent cause of hyperandrogenism in women of reproductive age. Among its metabolic complications, vitamin D deficiency has been described in relation with insulin resistance’s pathophysiology and other metabolic risk factors. However, it is not clear if this deficiency is inherent to PCOS or it depends on adiposity degree. As well, it is also suggested that vitamin D could regulate leptin levels and high leptin levels should be associated with vitamin D defiency in obesity. Our aim was to evaluate the relationship between vitamin D, leptin and obesity degree in PCOS patients. Subjects and methods: In 84 PCOS women (19 -37 years) and 49 controls (22-45 years), 25 hidroxi-vitamin D (25 OH-D) was measured by direct chemoluminiscence. Body mass index (BMI) was calculated; 20% of PCOS women were overweight and 46% were obese. Waist circumference (WC) was measured as an indicator of abdominal obesity. The lipid accumulation product (LAP) index, a secondary marker of insulin resistance, was calculated (LAP: [waist (cm) - 58] x triglycerides (mmol/l)). In a subgroup of 26 patients, leptin levels were determined by ELISA method. Statistical analysis was performed through SPSS 22. Results: Variables are expressed as mean ± SD or median (range) according to distribution. The following parameters were higher in PCOS women than in controls, BMI: 29.3 (18.6-48.2) vs 22.4 (18.1-37.4) kg/m2; WC 95 ± 16 vs 82 ± 11 cm and LAP: 47.9 (1.1-198.2) vs 17.5 (6.8-93.4) cm.mmol/L, p<0.0001 in all cases. 25 OH-D was lower in PCOS: 14.5 (10.0-39.0) vs 17.0 (10.0-38.8) ng/ml, p=0.024. Leptin levels in PCOS women were 10.1 ± 5.4, 26.4 ± 7.0 and 33.8 ± 16.9 ng/ml in normal weight, overweight and obese patients, respectively. After a logistic binary regression analysis, differences in 25 OH-D between groups were lost when BMI and WC were considered (p=0.556; RR=0.978; IC95% [0.909-1.063]). 25 OH-D levels were negatively associated with WC (r=-0.286, p=0.006), LAP (r=-0.333, p=0.002) and leptin (r=-0.462, p=0.017). Conclusions: although 25 OH-D levels were lower in PCOS women than in controls and negatively associated with LAP, an insulin resistant marker, the fact than differences between groups was lost after correction by BMI and WC, in addition to the correlation found between 25 OH-D and leptin levels, indicates that obesity degree and abdominal fat distribution should be responsible of decreased vitamin D levels in PCOS.

Vitamin D Levels in Women with Polycystic Ovary Syndrome

KnE Medicine ◽  
2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Elida Sidabutar
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Pcos Patient ◽  
Reproductive Age ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Vitamin D Levels

<p><strong>INTRODUCTION</strong>: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is some evidence suggested that vitamin D played a role in the incidence of PCOS. Previous research has found vitamin D deficiency in the pathogenesis of PCOS and cohort studies showing the relationship of obesity with decreased levels of 25-hydroxy vitamin D. Therefore, we aim to conduct a study on vitamin D levels in women with polycystic ovary syndrome.</p><p><strong>OBJECTIVE</strong>: To determine the difference of the levels of vitamin D in women with and without polycystic ovary syndrome.</p><p><strong>METHODS</strong>: This study is a comparative analytical study on two unpaired population by using cross-sectional study design. The study was conducted in Halim Fertility Clinic Medan starting in November 2014 through April 2015. Blood samples were taken from 23 women PCOS and 23 non-PCOS women. Further data were tabulated and analyzed.</p><p><strong>RESULTS</strong>: Vitamin D levels are lower in women with PCOS compared to controls. In the PCOS group, the levels of vitamin D were lower in obese women. Vitamin D levels were also lower in PCOS women with WHR&gt; 0.85.</p><strong>CONCLUSION</strong>: This study showed a significant lower level of vitamin D in PCOS patient.

scholarly journals Associations between vitamin D levels and polycystic ovary syndrome phenotypes

2019 ◽  
Vol 44 (2) ◽  
Author(s):  
Erin M. Davis ◽  
Jennifer D. Peck ◽  
Karl R. Hansen ◽  
Barbara R. Neas ◽  
LaTasha B. Craig
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Vitamin D Levels

scholarly journals Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis

Nutrients ◽  
2015 ◽  
Vol 7 (6) ◽  
pp. 4555-4577 ◽  
Author(s):  
Chunla He ◽  
Zhoumeng Lin ◽  
Sara Robb ◽  
Amara Ezeamama
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Ovary Syndrome ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Polymorphic Variations in VDR Gene in Saudi Women with and Without Polycystic Ovary Syndrome (PCOS) and Significant Influence of Seven Polymorphic Sites on Anthropometric And Hormonal Parameters

2018 ◽  
Vol 37 (4) ◽  
pp. 415-425 ◽  
Author(s):  
Arwa Al Thomali ◽  
Maha H. Daghestani ◽  
Mazin H. Daghestani ◽  
Namik Kaya ◽  
Arjumand Warsy
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Control Group ◽  
Ovary Syndrome ◽  
Vdr Gene ◽  
Saudi Women ◽  
Normal Controls ◽  
Genetic Analyzer

SummaryBackground:This study was designed to evaluate the associations between vitamin D receptor (VDR) gene polymorphisms and biochemical characteristics of Saudi women with polycystic ovary syndrome (PCOS).Methods:Serum levels of LH, FSH, and Vitamin D were measured in 33 women: 16 patients and 17 normal controls (18 to 36 years). DNA was extracted and used for sequencing of the exons ofVDRgene using ABI PRISM 3730xi Genetic Analyzer.Results:Weight, BMI, Vit D, LH and FSH levels were higher in the PCOS patients compared to control group, where Vit D level correlated positively and significantly with FSH, in the control, but showed a negative and non-significant correlation in the PCOS patients. Sequencing results showed extensive polymorphisms in both groups, but the differences in the frequencies were not significant. Demographic and hormonal parameters were compared in the different genotypes of the SNPs. Significant differences were ob served in the values of the studied parameters in rs11168276, rs11168266, rs3858733, rs121909790, rs11168265 and rs731236. Vitamin D level was influenced significantly by the genotypes of rs11168265 (AA) (p=0.008), rs11168276 (AA; p=0.018) and rs731236 (CC; p=0.024).Conclusion:Vitamin D deficiency does not associate with PCOS in Saudi females. Several SNPs are identified in the VDR gene, in normal and PCOS females, but there is no difference in their frequencies between the two groups. The results show that polymorphism in VDR gene influences certain anthropometric and hormonal parameters in PCOS patients. Further detailed studies are required to confirm the associations between VDR and PCOS.

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