Dehydroepiandrosterone Sulfate Level is Lower in Polycystic Ovary Syndrome Patients with Autoimmune Thyroid Disease

Objective: To investigate the prevalence of polycystic ovary syndrome (PCOS) and its comorbidities in patients with autoimmune thyroid disease (AITD). Population: In this cohort study, patients newly diagnosed as having Hashimoto thyroiditis (HT) or Grave disease (GD) were recruited into the AITD group. Method: The logistic regression model was used to investigate the association between exposure, endpoint, later diseases and treatment. Main Outcome Measures: We assessed the cumulative incidence using the Kaplan–Meier method and verified the difference by the log-rank test. Results: The AITD group included 3599 GD patients and 1332 HT patients. PCOS risk in patients with AITD was higher than that in the control group (adjusted hazard ratio = 1.39; 95% confidence interval = 1.07–1.71). In patients with both AITD and PCOS, the odds ratios of diabetes, hyperlipidemia and coronary artery disease were 2.48, 2.05 and 2.63, respectively. Conclusions: The risks of PCOS and its comorbidities such as diabetes, dyslipidemia and cardiac artery disease are high in patients with AITD in Taiwan.

Download Full-text

Low 25 (OH) vitamin D levels are associated with autoimmune thyroid disease in polycystic ovary syndrome

Endocrine ◽

10.1007/s12020-015-0745-0 ◽

2015 ◽

Vol 53 (2) ◽

pp. 538-542 ◽

Cited By ~ 10

Author(s):

Giovanna Muscogiuri ◽

Stefano Palomba ◽

Mario Caggiano ◽

Domenico Tafuri ◽

Annamaria Colao ◽

...

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Autoimmune Thyroid ◽

Vitamin D Levels ◽

25 Oh Vitamin D

Download Full-text

Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome

Journal of the Turkish-German Gynecological Association ◽

10.4274/jtgga.2016.0217 ◽

2017 ◽

Vol 18 (2) ◽

pp. 85-89 ◽

Cited By ~ 4

Author(s):

Melia Karaköse ◽

Sema Hepsen ◽

Erman Çakal ◽

Müyesser Saykı Arslan ◽

Esra Tutal ◽

...

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Polycystic Ovary ◽

Nodular Goiter ◽

Ovary Syndrome ◽

Autoimmune Thyroid

Download Full-text

Alarin/FSH Ratio Might Be A New Biological Marker in Polycystic Ovary Syndrome Women with Normal and Women with Obese

Journal of Gynecology & Reproductive Medicine ◽

10.33140/jgrm.03.05.04 ◽

2019 ◽

Vol 3 (5) ◽

Keyword(s):

Luteinizing Hormone ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Density Lipoprotein ◽

Biological Marker ◽

Dehydroepiandrosterone Sulfate ◽

Normal Weight ◽

Control Group ◽

Total Testosterone ◽

Ovary Syndrome

Neuropeptides coordinate and regulate physiological processes in all animals. Alarin is a 25 amino acid neuropeptide which promotes the secretion of luteinizing hormone (LH). It has been known that serum luteinizing hormone levels are increased in women with polycystic ovary syndrome. Therefore, purpose of this was to examine the association of circulating gonadotropin secretions, and alarin with women with polycystic ovary syndrome, and to compare these findings with those of control subjects in an effort to better understand the pathophysiology of PCOS. 28 participants with a diagnosis of PCOS with normal weight and 28 participants with a diagnosis of PCOS with obese and 28 control group participants were included in this case-control study. Hormone profiles of the participants (alarin, insulin, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-SO4 ), lipid profiles total testosterone, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, cholesterol) and fasting blood sugar (FBS) values were measured. Results: Serum androgens were elevated in the PCOS. Blood LH was also elevated (P < 0.05) but was higher in PCOS than Control. Patients with PCOS had an increased alarin compared with controls. LH/FSH ratio and Alarin /FSH ratio were greater than 2.1, 2.4, respectively. The blood alarin levels were significantly correlated with the serum LH levels (r=0.492, p=0.002) and the LH/FSH ratios (r=0.450, p<0.001) and Alarin/ FSH ratios. The FSH/LH and alarin /FSH ratio were elevated in the PCOS. Based on these results, the FSH/LH and Alarin /FSH ratio appears to be a useful marker of PCOS.

Download Full-text

Polycystic ovary syndrome: clinical and laboratory evaluation

Sao Paulo Medical Journal ◽

10.1590/s1516-31801996000400006 ◽

1996 ◽

Vol 114 (4) ◽

pp. 1222-1225 ◽

Cited By ~ 4

Author(s):

Marcos Yorghi Khoury ◽

Edmund Chada Baracat ◽

Dolores Perovano Pardini ◽

Mauro Abi Haidar ◽

Eduardo Leme Alves da Motta ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Laboratory Tests ◽

Late Onset ◽

Polycystic Ovary ◽

Free Testosterone ◽

Dehydroepiandrosterone Sulfate ◽

Laboratory Evaluation ◽

Clinical Feature ◽

Age At Menarche ◽

Ovary Syndrome

OBJECTIVE: To evaluate clinically, and with laboratory, tests, women with polycystic ovary syndrome (PCO). PATIENTS: One hundred and twelve women with PCO were studied. METHODS: The following data was recorded: Current age; age at menarche; menstrual irregularity, occurrence of similar cases in the family; fertility, obstetric history; body mass index (BMI); and presence of hirsutism. Serum measurements of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, free testosterone, and dehydroepiandrosterone sulfate were taken. RESULTS: All patients presented either oligomenorrhea (31 percent), periods of secondary amenorrhea (9 percent), or both alterations (60 percent). The majority of the patients were infertile (75.6 percent). The LH/FSH ratio was higher than 2:1 in 55 percent of the patients and higher than 3:1 in 26.2 percent. The ultrasonographic aspect of the ovaries was considered to be normal in 31 percent. CONCLUSION: The main clinical feature of the PCO is the irregularity of menses since menarche, and that the laboratory tests would be important to exclude other disorders such as hyperprolactinemia or hyperandrogenemia caused by late-onset congenital adrenal hyperplasia.

Download Full-text

Serum Melatonin in Women with Polycystic Ovary Syndrome

Folia Medica ◽

10.2478/folmed-2013-0012 ◽

2013 ◽

Vol 55 (2) ◽

pp. 10-15 ◽

Cited By ~ 7

Author(s):

Dora D. Terzieva ◽

Maria M. Orbetzova ◽

Mitko D. Mitkov ◽

Nonka G. Mateva

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Serum Levels ◽

Dehydroepiandrosterone Sulfate ◽

Immunoreactive Insulin ◽

Total Testosterone ◽

Melatonin Level ◽

Night Time ◽

Ovary Syndrome ◽

Healthy Women

ABSTRACT There has been a surge of interest in recent years in studying the changes of serum melatonin concentrations in disorders that are associated with insulin resistance such as diabetes mellitus type 2 and polycystic ovary syndrome (PCOS). AIM: The present study was designed to investigate the day-time and night-time levels of serum melatonin and the cortisol rhythm in women with PCOS and compare them with those of healthy women. PATIENTS AND METHODS: This is a case-control study which included 30 women with PCOS and 25 healthy women. All hormonal measurements in both the study group and controls were carried out between days 3 and 5 counted from the beginning of the last regular menstrual cycle; they included serum levels of melatonin and cortisol at 03:00 a.m and 08:00 a.m, total testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), luteinizing hormone (LH), follicle stimulating hormone (FSH), and immunoreactive insulin at 08:00 a.m. RESULTS: Women with PCOS were found to have a significantly higher melatonin level at 08:00 a.m. and smaller mean night-day difference in the concentrations of melatonin in comparison with those of healthy women (natural log (Ln) night-day difference 0.60 ± 0.10 pg/ml versus 1.15 ± 0.14, p < 0.002). Melatonin to cortisol ratios at 03:00 a.m. and 08:00 a.m. showed no statistically significant differences between the two groups (Ln melatonin/ cortisol 03:00 a.m., 1.01 ± 0.06 versus 1.05 ± 0.05; Ln melatonin/cortisol at 08:00 a.m., 0.62 ± 0.01 versus 0.56 ± 0.03, p > 0.05). CONCLUSION: The results we obtained about the changes of melatonin in women with PCOS could help in elucidating the complex pathophysiological pattern of this disease.

Download Full-text