Associations between vitamin D levels and polycystic ovary syndrome phenotypes

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. In this study, serum 25-hydroxyvitamin D levels were compared between women with and without PCOS and with regard to anthropometric indices and lipid and glucose biomarkers. Thirty-one women with PCOS and 75 controls answered a questionnaire on vitamin D, in addition to general health and lifestyle. The patients with PCOS had lower vitamin D levels (p < 0.05), a significantly higher rate of obesity (p < 0.05), and significantly higher serum triglyceride levels than did controls. The number of patients with PCOS consumed milk and dairy products (p < 0.05) and exposed to sun (p < 0.006) were lower compared to controls. Triglyceride levels were significantly correlated with body mass index (BMI); vitamin D level was not significantly correlated with anthropometrical or biochemical variables. These results affirm that vitamin D levels are lower in women with PCOS; however, despite the significantly higher proportion of obesity among patients with PCOS, hypovitaminosis was not associated with BMI. The relationship between body composition and vitamin D in PCOS and the effect of vitamin D correction on metabolic and hormonal parameters associated with PCOS must be assessed in future trials.

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Serum 25-Hydroxy vitamin D levels and insulin resistance in polycystic ovary syndrome

Endocrine Abstracts ◽

10.1530/endoabs.56.ep143 ◽

2018 ◽

Author(s):

Ozen Oz Gul ◽

Firdevs Ulutas ◽

Soner Cander ◽

Canan Ersoy

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

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Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu7064555 ◽

2015 ◽

Vol 7 (6) ◽

pp. 4555-4577 ◽

Cited By ~ 65

Author(s):

Chunla He ◽

Zhoumeng Lin ◽

Sara Robb ◽

Amara Ezeamama

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Meta Analysis ◽

Serum Vitamin ◽

Ovary Syndrome ◽

Serum Vitamin D ◽

Vitamin D Levels

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Serum 25-Hydroxy Vitamin D Levels in Turkish Adolescent Girls with Polycystic Ovary Syndrome and the Correlation with Clinical/Biochemical Parameters

Journal of Pediatric and Adolescent Gynecology ◽

10.1016/j.jpag.2017.07.008 ◽

2018 ◽

Vol 31 (3) ◽

pp. 270-273 ◽

Cited By ~ 1

Author(s):

Esra Isci Bostanci ◽

Sibel Ozler ◽

Nafiye Karakas Yilmaz ◽

Huseyin Yesilyurt

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Adolescent Girls ◽

Biochemical Parameters ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

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Study of serum calcium and vitamin D levels with hormonal profile along with biochemical profile in women with polycystic ovary syndrome

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174065 ◽

2017 ◽

Vol 6 (9) ◽

pp. 4075

Author(s):

Ilangovan Subashree ◽

Umakant Ramchandra Valvekar ◽

Geetha Prasad

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Vitamin D Deficiency ◽

Serum Calcium ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Control Female ◽

Hormonal Profile ◽

Vitamin D Levels

Background: The polycystic ovary syndrome (PCOS) is one of the commonest human endocrinopathies and is increasingly recognized as a variant of the metabolic syndrome in women with the characteristic features of insulin resistance, central obesity, impaired glucose metabolism, dyslipidemia, and hypertension.Methods: This study is mainly focused on study of parameters like gonadotropin hormonal profile, serum vitamin D and calcium levels in polycystic ovary disease (PCOD). The study comprised 45 clinically proven polycystic ovary disease patients in the age range of 19-34 years. The biochemical estimations carried out in the study were – Fasting Blood sugar, LH, FSH, prolactin, 25- OH vitamin D and calcium along with anthropometric data. The values obtained were compared with age matched equal number of healthy control female subjects from the same population.Results: The serum concentration of calcium and vitamin D levels are decreased significantly (P <0.001) when compared to controls. Insulin resistance is predominantly seen in PCOS subjects. The study outlines the importance of insulin resistance, dyslipidemia, decreased serum calcium and vitamin D levels in PCOS subjects may be a cause for the progression of polycystic ovary syndrome.Conclusions: In the present study vitamin D deficiency is highly prevalent in PCOS women from this area compared to control women. We also relations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women. A high prevalence of vitamin D deficiency and low calcium levels were observed in PCOS women from our population when compared to controls. Insulin resistance was predominantly seen in PCOS subjects when compared with controls, indicating the association of vitamin D levels with insulin resistance.

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MON-037 Vitamin D Levels in Women with Polycystic Ovary Syndrome: Influence of Obesity

Journal of the Endocrine Society ◽

10.1210/jendso/bvaa046.944 ◽

2020 ◽

Vol 4 (Supplement_1) ◽

Author(s):

Patricia Nieves Amelia Maidana ◽

Gladys Isabel Fernández ◽

Analy Fritzler ◽

María Gabriela Ropelato ◽

Lamas-Majek Eugenia ◽

...

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Fat Distribution ◽

Normal Weight ◽

Reproductive Age ◽

Ovary Syndrome ◽

Metabolic Complications ◽

Negatively Associated ◽

Vitamin D Levels

Abstract Introduction: Polycystic ovary syndrome (PCOS) is the most frequent cause of hyperandrogenism in women of reproductive age. Among its metabolic complications, vitamin D deficiency has been described in relation with insulin resistance’s pathophysiology and other metabolic risk factors. However, it is not clear if this deficiency is inherent to PCOS or it depends on adiposity degree. As well, it is also suggested that vitamin D could regulate leptin levels and high leptin levels should be associated with vitamin D defiency in obesity. Our aim was to evaluate the relationship between vitamin D, leptin and obesity degree in PCOS patients. Subjects and methods: In 84 PCOS women (19 -37 years) and 49 controls (22-45 years), 25 hidroxi-vitamin D (25 OH-D) was measured by direct chemoluminiscence. Body mass index (BMI) was calculated; 20% of PCOS women were overweight and 46% were obese. Waist circumference (WC) was measured as an indicator of abdominal obesity. The lipid accumulation product (LAP) index, a secondary marker of insulin resistance, was calculated (LAP: [waist (cm) - 58] x triglycerides (mmol/l)). In a subgroup of 26 patients, leptin levels were determined by ELISA method. Statistical analysis was performed through SPSS 22. Results: Variables are expressed as mean ± SD or median (range) according to distribution. The following parameters were higher in PCOS women than in controls, BMI: 29.3 (18.6-48.2) vs 22.4 (18.1-37.4) kg/m2; WC 95 ± 16 vs 82 ± 11 cm and LAP: 47.9 (1.1-198.2) vs 17.5 (6.8-93.4) cm.mmol/L, p<0.0001 in all cases. 25 OH-D was lower in PCOS: 14.5 (10.0-39.0) vs 17.0 (10.0-38.8) ng/ml, p=0.024. Leptin levels in PCOS women were 10.1 ± 5.4, 26.4 ± 7.0 and 33.8 ± 16.9 ng/ml in normal weight, overweight and obese patients, respectively. After a logistic binary regression analysis, differences in 25 OH-D between groups were lost when BMI and WC were considered (p=0.556; RR=0.978; IC95% [0.909-1.063]). 25 OH-D levels were negatively associated with WC (r=-0.286, p=0.006), LAP (r=-0.333, p=0.002) and leptin (r=-0.462, p=0.017). Conclusions: although 25 OH-D levels were lower in PCOS women than in controls and negatively associated with LAP, an insulin resistant marker, the fact than differences between groups was lost after correction by BMI and WC, in addition to the correlation found between 25 OH-D and leptin levels, indicates that obesity degree and abdominal fat distribution should be responsible of decreased vitamin D levels in PCOS.

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