Two-year changes of biochemical profiles and bone mineral density after percutaneous ultrasound-guided microwave ablation for primary hyperparathyroidism

Endocrine ◽  
2020 ◽  
Author(s):  
Wenjun Wu ◽  
Qi Zhou ◽  
Shihao Xu ◽  
Siqin An ◽  
Feixia Shen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Microwave Ablation ◽  
Ultrasound Guided ◽  
Mineral Density ◽  
Biochemical Profiles

scholarly journals P114 Effect of vitamin D on parathyroid hormone, serum calcium and bone mineral density in patients with primary hyperparathyroidism being managed conservatively

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Mahrukh Khalid ◽  
Vismay Deshani ◽  
Khalid Jadoon
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Mineral Density ◽  
Neck Of Femur ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract Background/Aims  Vitamin D deficiency is associated with more severe presentation of primary hyperparathyroidism (PTHP) with high parathyroid hormone (PTH) levels and reduced bone mineral density (BMD). We analyzed data to determine if vitamin D levels had any impact on PTH, serum calcium and BMD at diagnosis and 3 years, in patients being managed conservatively. Methods  Retrospective analysis of patients presenting with PHPT. Based on vitamin D level at diagnosis, patients were divided into two groups; vitamin D sufficient (≥ 50 nmol/L) and vitamin D insufficient (≤ 50 nmol/L). The two groups were compared for age, serum calcium and PTH levels at diagnosis and after mean follow up of 3 years. BMD at forearm and neck of femur (NOF) was only analyzed in the two groups at diagnosis, due to lack of 3 year’s data. Results  There were a total of 93 patients, 17 males, mean age 70; range 38-90. Mean vitamin D level was 73.39 nmol/L in sufficient group (n = 42) and 34.48 nmol/L in insufficient group (n = 40), (difference between means -38.91, 95% confidence interval -45.49 to -32.33, p < 0.0001). There was no significant difference in age, serum calcium and PTH at the time of diagnosis. After three years, there was no significant difference in vitamin D levels between the two groups (mean vitamin D 72.17 nmol/L in sufficient group and 61.48 nmol/L in insufficient group). Despite rise in vitamin D level in insufficient group, no significant change was observed in this group in PTH and serum calcium levels. BMD was lower at both sites in vitamin D sufficient group and difference was statistically significant at NOF. Data were analyzed using unpaired t test and presented as mean ± SEM. Conclusion  50% of patients presenting with PHPT were vitamin D insufficient at diagnosis. Vitamin D was adequately replaced so that at 3 years there was no significant difference in vitamin D status in the two groups. Serum calcium and PTH were no different in the two groups at diagnosis and at three years, despite rise in vitamin D levels in the insufficient group. Interestingly, BMD was lower at forearm and neck of femur in those with sufficient vitamin D levels and the difference was statistically significant at neck of femur. Our data show that vitamin D insufficiency does not have any significant impact on PTH and calcium levels and that vitamin D replacement is safe in PHPT and does not impact serum calcium and PTH levels in the short term. Lower BMD in those with adequate vitamin D levels is difficult to explain and needs further research. Disclosure  M. Khalid: None. V. Deshani: None. K. Jadoon: None.

Insulin Sensitivity and Bone Mineral Density in Primary Hyperparathyroidism

2011 ◽  
pp. P1-238-P1-238
Author(s):  
Francesco Tassone ◽  
Laura Gianotti ◽  
Flora Cesario ◽  
Claudia Baffoni ◽  
Micaela Pellegrino ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Insulin Sensitivity ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density

Analysis of the Increase in Bone Mineral Density After Surgical Treatment of Primary Hyperparathyroidism

2019 ◽  
Vol 22 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Fernando Mendoza-Moreno ◽  
Manuel Díez-Alonso ◽  
Enrique Ovejero-Merino ◽  
Ana Sánchez-Gollarte ◽  
Ricardo Alvarado-Hurtado ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Surgical Treatment ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Bone mineral density evolution after parathyroidectomy in patients with primary hyperparathyroidism

2015 ◽  
Author(s):  
Alicia Vicuna ◽  
Ana Ramos-Levi ◽  
Miguel Sampedro-Nunez ◽  
Sandra Campos ◽  
Magaly Zelada ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density ◽  
Density Evolution

Weight gain after curative parathyroidectomy predicts increase in bone mineral density in patients with symptomatic primary hyperparathyroidism

2020 ◽  
Vol 93 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Rimesh Pal ◽  
Ashutosh K. Arya ◽  
Anshita Aggarwal ◽  
Priyanka Singh ◽  
Divya Dahiya ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Weight Gain ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Erratum to: Predictors of Bone Mineral Density Improvement in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism

2014 ◽  
Vol 38 (10) ◽  
pp. 2740-2740
Author(s):  
Jyotirmay Sharma ◽  
Dina S. Itum ◽  
Lewis Moss ◽  
C. Li ◽  
Collin Weber
Keyword(s):  
Bone Mineral Density ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density

Recovery of Bone Mineral Density in 126 Patients after Surgery for Primary Hyperparathyroidism

2004 ◽  
Vol 28 (5) ◽  
pp. 502-507 ◽  
Author(s):  
Erik Nordenstr�m ◽  
Johan Westerdahl ◽  
Anders Bergenfelz
Keyword(s):  
Bone Mineral Density ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Mineral Density
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