Size-Related Differences in Computed Tomography Markers of Hematoma Expansion in Acute Intracerebral Hemorrhage

2021 ◽  
Author(s):  
Yong Soo Kim ◽  
Hee-Yun Chae ◽  
Han-Gil Jeong ◽  
Beom Joon Kim ◽  
Si-Un Lee ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Intracerebral Hemorrhage ◽  
Hematoma Expansion ◽  
Acute Intracerebral Hemorrhage

scholarly journals Tranexamic Acid for Prevention of Hematoma Expansion in Intracerebral Hemorrhage Patients With or Without Spot Sign

Stroke ◽  
2021 ◽  
Author(s):  
Christian Ovesen ◽  
Janus Christian Jakobsen ◽  
Christian Gluud ◽  
Thorsten Steiner ◽  
Zhe Law ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Intracerebral Hemorrhage ◽  
Tranexamic Acid ◽  
Symptom Onset ◽  
Odds Ratio ◽  
Hematoma Expansion ◽  
Spot Sign ◽  
Main Trial ◽  
Acid Versus ◽  
Acute Intracerebral Hemorrhage

Background and Purpose: The computed tomography angiography or contrast-enhanced computed tomography based spot sign has been proposed as a biomarker for identifying on-going hematoma expansion in patients with acute intracerebral hemorrhage. We investigated, if spot-sign positive participants benefit more from tranexamic acid versus placebo as compared to spot-sign negative participants. Methods: TICH-2 trial (Tranexamic Acid for Hyperacute Primary Intracerebral Haemorrhage) was a randomized, placebo-controlled clinical trial recruiting acutely hospitalized participants with intracerebral hemorrhage within 8 hours after symptom onset. Local investigators randomized participants to 2 grams of intravenous tranexamic acid or matching placebo (1:1). All participants underwent computed tomography scan on admission and on day 2 (24±12 hours) after randomization. In this sub group analysis, we included all participants from the main trial population with imaging allowing adjudication of spot sign status. Results: Of the 2325 TICH-2 participants, 254 (10.9%) had imaging allowing for spot-sign adjudication. Of these participants, 64 (25.2%) were spot-sign positive. Median (interquartile range) time from symptom onset to administration of the intervention was 225.0 (169.0 to 310.0) minutes. The adjusted percent difference in absolute day-2 hematoma volume between participants allocated to tranexamic versus placebo was 3.7% (95% CI, −12.8% to 23.4%) for spot-sign positive and 1.7% (95% CI, −8.4% to 12.8%) for spot-sign negative participants ( P heterogenity =0.85). No difference was observed in significant hematoma progression (dichotomous composite outcome) between participants allocated to tranexamic versus placebo among spot-sign positive (odds ratio, 0.85 [95% CI, 0.29 to 2.46]) and negative (odds ratio, 0.77 [95% CI, 0.41 to 1.45]) participants ( P heterogenity =0.88). Conclusions: Data from the TICH-2 trial do not support that admission spot sign status modifies the treatment effect of tranexamic acid versus placebo in patients with acute intracerebral hemorrhage. The results might have been affected by low statistical power as well as treatment delay. REGISTRATION: URL: http://www.controlled-trials.com ; Unique identifier: ISRCTN93732214.

scholarly journals Neuroimaging of Acute Intracerebral Hemorrhage

2021 ◽  
Vol 10 (5) ◽  
pp. 1086
Author(s):  
Peter B. Sporns ◽  
Marios-Nikos Psychogios ◽  
Grégoire Boulouis ◽  
Andreas Charidimou ◽  
Qi Li ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Intracerebral Hemorrhage ◽  
Rapid Assessment ◽  
Vascular Imaging ◽  
Hematoma Expansion ◽  
High Morbidity ◽  
Potential Hazard ◽  
Increased Risk ◽  
Underlying Causes ◽  
Acute Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) accounts for 10% to 20% of all strokes worldwide and is associated with high morbidity and mortality. Neuroimaging is clinically important for the rapid diagnosis of ICH and underlying etiologies, but also for identification of ICH expansion, often as-sociated with an increased risk for poor outcome. In this context, rapid assessment of early hema-toma expansion risk is both an opportunity for therapeutic intervention and a potential hazard for hematoma evacuation surgery. In this review, we provide an overview of the current literature surrounding the use of multimodal neuroimaging of ICH for etiological diagnosis, prediction of early hematoma expansion, and prognostication of neurological outcome. Specifically, we discuss standard imaging using computed tomography, the value of different vascular imaging modalities to identify underlying causes and present recent advances in magnetic resonance imaging and computed tomography perfusion.

Quantitative assessment of local perfusion change in acute intracerebral hemorrhage areas with and without “dynamic spot sign” using CT perfusion imaging

2018 ◽  
Vol 60 (3) ◽  
pp. 367-373
Author(s):  
Fan Fu ◽  
Binbin Sui ◽  
Liping Liu ◽  
Yaping Su ◽  
Shengjun Sun ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Intracerebral Hemorrhage ◽  
Hematoma Expansion ◽  
Control Group ◽  
Regional Cerebral Blood ◽  
Spot Sign ◽  
Positive Group ◽  
Regional Cerebral Blood Volume ◽  
Acute Intracerebral Hemorrhage

Background Positive “dynamic spot sign” has been proven to be a potential risk factor for acute intracerebral hemorrhage (ICH) expansion, but local perfusion change has not been quantitatively investigated. Purpose To quantitatively evaluate perfusion changes at the ICH area using computed tomography perfusion (CTP) imaging. Material and Methods Fifty-three patients with spontaneous ICH were recruited. Unenhanced computed tomography (NCCT), CTP within 6 h, and follow-up NCCT were performed for 21 patients in the “spot sign”-positive group and 32 patients in the control group. Cerebral perfusion change was quantitatively measured on regional cerebral blood flow/regional cerebral blood volume (rCBF/rCBV) maps. Regions of interest (ROIs) were set at the “spot-sign” region and the whole hematoma area for “spot-sign”-positive cases, and at one of the highest values of three interested areas and the whole hematoma area for the control group. Hematoma expansion was determined by follow-up NCCT. Results For the “spot-sign”-positive group, the average rCBF (rCBV) values at the “spot-sign” region and the whole hematoma area were 21.34 ± 15.24 mL/min/100 g (21.64 ± 21.48 mL/100g) and 5.78 ± 6.32 mL/min/100 g (6.07 ± 5.45 mL/100g); for the control group, the average rCBF (rCBV) values at the interested area and whole hematoma area were 2.50 ± 1.83 mL/min/100 g (3.13 ± 1.96 mL/100g) and 3.02 ± 1.80 mL/min/100 g (3.40 ± 1.44 mL/100g), respectively. Average rCBF and rCBV values of the “spot-sign” region were significantly different from other regions ( P < 0.001; P = 0.004). The average volumes of hematoma expansion in the “spot-sign”-positive and control groups were 25.24 ± 19.38 mL and −0.41 ± 1.34 mL, respectively. Conclusion The higher perfusion change at ICH on CTP images may reflect the contrast extravasation and be associated with the hematoma expansion.

Advances in CT for prediction of hematoma expansion in acute intracerebral hemorrhage

2013 ◽  
Vol 5 (6) ◽  
pp. 539-551 ◽  
Author(s):  
Thien J Huynh ◽  
Sean P Symons ◽  
Richard I Aviv
Keyword(s):  
Intracerebral Hemorrhage ◽  
Hematoma Expansion ◽  
Acute Intracerebral Hemorrhage

scholarly journals Hematoma Expansion following Acute Intracerebral Hemorrhage

2013 ◽  
Vol 35 (3) ◽  
pp. 195-201 ◽  
Author(s):  
H. Bart Brouwers ◽  
Steven M. Greenberg
Keyword(s):  
Intracerebral Hemorrhage ◽  
Hematoma Expansion ◽  
Acute Intracerebral Hemorrhage

scholarly journals Effect of Heart Rate Variabilities on Outcome After Acute Intracerebral Hemorrhage: A Post Hoc Analysis of ATACH‐2

2021 ◽  
Author(s):  
Kaori Miwa ◽  
Masatoshi Koga ◽  
Mayumi Fukuda‐Doi ◽  
Haruko Yamamoto ◽  
Kanata Tanaka ◽  
...  
Keyword(s):  
Heart Rate ◽  
Intracerebral Hemorrhage ◽  
Unfavorable Outcome ◽  
Hematoma Expansion ◽  
Unique Identifier ◽  
Therapeutic Implications ◽  
Acute Intracerebral Hemorrhage ◽  
Average Real Variability ◽  
Deviation Coefficient ◽  
Post Hoc

Background To explore how the clinical impact of heart rate (HR) and heart rate variabilities (HRV) during the initial 24 hours after acute intracerebral hemorrhage (ICH) contribute to worse clinical outcomes. Methods and Results In the ATACH‐2 (Antihypertensive Treatment in Intracerebral Hemorrhage 2) trial, the HR was recorded for every 15 minutes from baseline to 1 hour and hourly during the initial 24 hours post‐randomization. We calculated the following: mean, standard deviation, coefficient of variation, successive variation, and average real variability (ARV). Outcomes were hematoma expansion at 24 hours and unfavorable functional outcome, defined as modified Rankin Scale score 4 to 6 at 90 days. Of the 1000 subjects in ATACH‐2, 994 with available HR data were included in the analyses. Overall, 262 experienced hematoma expansion, and 362 had unfavorable outcomes. Increased mean HR was linearly associated with unfavorable outcome (per 10 bpm increase adjusted odds ratio [aOR], 1.31, 95% CI, 1.14–1.50) but not with hematoma expansion, while HR‐ARV was associated with hematoma expansion (aOR, 1.06, 95% CI, 1.01–1.12) and unfavorable outcome (aOR, 1.07, 95% CI, 1.01–1.3). Every 10‐bpm increase in mean HR increased the probability of unfavorable outcome by 4.3%, while every 1 increase in HR‐ARV increased the probability of hematoma expansion by 1.1% and unfavorable outcome by 1.3%. Conclusions Increased mean HR and HR‐ARV within the initial 24 hours were independently associated with unfavorable outcome in acute ICH. Moreover, HR‐ARV was associated with hematoma expansion at 24 hours. This may have future therapeutic implications to accommodate HR and HRV in acute ICH. Registration URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT01176565.

SOME PREDICTING FACTORS OF HEMATOMA EXPANSION AFTER PRIMARY INTRACEREBRAL HEMORRHAGE

2017 ◽  
pp. 31-37
Author(s):  
Song Hao Nguyen ◽  
Quoc Chinh Luong ◽  
Dang Luu Vu ◽  
Dat Anh Nguyen ◽  
Duy Ton Mai
Keyword(s):  
Computed Tomography ◽  
Intracerebral Hemorrhage ◽  
Clinical Symptoms ◽  
Hematoma Expansion ◽  
Univariable Analysis ◽  
Liver Transaminase ◽  
Blood Tests ◽  
Predicting Factors ◽  
Neurologic Emergency ◽  
Symptoms And Signs

Background and purpose: Primary intracerebral hemorrhage is a common neurologic emergency, with high mortality rate, severe sequela and also burdens for families and society. Hematoma expansions after acute primary intracerebral hemorrhage are very important complications that worsen the clinical outcome. Thus, the aim of this research is to predict some factors of the mobidity. Methods: We performed a descriptive, observative study of 32 patients with acute primary intracerebral hemorrhage within 6 hours after onset at The Emergency Department, Bach Mai Hospital from November 2014 to July 2016. The computed tomography (CT) and computed tomography angiography (CTA) were indicated for all patients before 6 hours of onset and repeated CLVT without contrast after 24 hours. Patients were divided into 2 groups with or without hematoma expansions to investigate clinical symptoms and signs, blood tests and neuroimaging in univariable analysis of some predicting factors of hematoma expansion. Results: Research on 32 patients with striCLVT criteria showed that the rate of hematoma expansion occurred in 40.6% and spot signs on CTA was seen in 25% (8/32) of cases. There were 5 factors which might associate to hematoma expansions including time from onset to admission less than 3 hours (55% before 3h vs 16.7% after 3h, p<0.05), low prothrombine ratio (83.8±12.2% vs 97.7±18%, p<0.05), liver transaminase elevations, heterogeneous hematoma shapes and chấm máu signs on CTA. Conclusions: In univariable analysis, there were 5 early predicting factors which might relate to hematoma expansions for acute primary intracerebral hemorrhage, including time from onset to admission less than 3 hours, spot signs on CTA, heterogeneous hematoma shapes, liver transaminase elevations and low prothrombin ratio. Key words: Primary intracerebral hemorrhage, clinical

Abstract TP333: The Volume of an Acute Intracerebral Hemorrhage May Be Larger Than it Appears on Computed Tomography Scan

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Takahiro Sato
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Intracerebral Hemorrhage ◽  
Ct Imaging ◽  
Low Density ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Acute Intracerebral Hemorrhage ◽  
Ct And Mri

Background and Purpose: Computed tomography (CT) scan is difficult to detect early-onset acute intracerebral hemorrhage (ICH) rich in fresh blood correctly. We identified the presence of a perihematomal low-density lesion on CT imaging, which showed a high-intensity signal on T2-weighted imaging and an iso-intensity signal on fluid-attenuated inversion recovery imaging in magnetic resonance imaging (MRI) (Figure. A~C). It located inside of the hypo-intensity rim at the edge of hematoma on gradient recalled echo T2*-weighted imaging (Figure. D). We named it the “CT wall sign” and investigated the association with imaging findings in acute ICH. Methods: Patients with acute ICH within 24 hours from onset who underwent non-contrast head CT and MRI scan at the same time periods were included. The ICH volumes on CT and MRI (cm 3 ) were measured using a three-dimensional slicer and compared. Subjects were divided according to the presence or absence of the CT wall sign and compared the neuroradiological variables. Statistical analyses were performed to evaluate the association between the CT wall sign and other imaging findings. Results: A total of 146 patients were included and the CT wall sign was observed in 42 (29%) patients. The difference in the ICH volume between MRI and CT were significantly larger in the CT wall sign-positive group than in -negative group (6.0 cm 3 versus 0.40 cm 3 , P <0.001). The presence of CT wall sign was significantly associated with putamen hemorrhage ( P =0.049), large hematoma > 11.36 cm 3 ( P =0.005), and niveau formation in the hematoma ( P <0.001). Conclusions: The presence of the CT wall sign suggests that the volume of an acute ICH may be larger than it appears on CT imaging. Key words: Acute intracerebral hemorrhage, Computed tomography, Magnetic resonance imaging, Perihematomal low-density area.

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