Anorectal Cancer in Crohn’s Disease Has a Poor Prognosis Due to its Advanced Stage and Aggressive Histological Features: a Systematic Literature Review of Japanese Patients

2018 ◽  
Vol 51 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Takeshi Ueda ◽  
Takashi Inoue ◽  
Takayuki Nakamoto ◽  
Naoto Nishigori ◽  
Hiroyuki Kuge ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Poor Prognosis ◽  
Japanese Patients ◽  
Advanced Stage ◽  
Histological Features ◽  
Anorectal Cancer

scholarly journals Prevalence of Fistulizing Crohn’s Disease in the United States: Estimate From a Systematic Literature Review Attempt and Population-Based Database Analysis

2019 ◽  
Vol 25 (11) ◽  
pp. 1773-1779 ◽  
Author(s):  
David A Schwartz ◽  
Ignacio Tagarro ◽  
Mary Carmen Díez ◽  
William J Sandborn
Keyword(s):  
United States ◽  
Health Care ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Literature Review ◽  
Systematic Literature Review ◽  
The United States ◽  
Population Based ◽  
Number Of Patients ◽  
Reported Data

Abstract Background Fistulas may arise as a relevant complication of Crohn’s disease (CD). Despite their clinical significance and the substantial burden imposed on patients, limited data are available on the epidemiology of fistulizing CD in the United States. Methods A systematic literature review was conducted to identify data published between 1970 and 2017 on the epidemiology of fistulas in patients with CD, with the aim to estimate the number of prevalent cases in the United States. Retrieved titles and abstracts were screened by 2 independent researchers for inclusion criteria (US population-based studies reporting data on the epidemiology of fistulizing CD). To validate the literature-based estimate, data from a US claims database (Truven Health MarketScan database) were analyzed. This database has broad geographic coverage, with health care data for >60 million patients during the period of the analysis. Results The literature search retrieved 7 articles for full-text review, and only 1 met the criteria for inclusion. This study described the cumulative incidence of fistulas in a CD population from Minnesota over 20 years. From the reported data, the estimated number of prevalent cases with fistulizing CD in the United States was ~76,600 in 2017 (~52,900 anal, ~7400 rectovaginal, ~2300 enterocutaneous, and ~14,100 internal). Analysis from the US health care database resulted in an estimated number of ~75,700 patients, confirming the robustness of the original estimate from the literature. Conclusions Based on 2 separate analyses, the estimated number of patients with fistulizing CD in the United States is ~77,000 patients.

scholarly journals A Systematic Review of the Patient Burden of Crohn’s Disease-related Rectovaginal and Anovaginal Fistulas

2021 ◽  
Author(s):  
Kristy Iglay ◽  
Dimitri Bennett ◽  
Michael Kappelman ◽  
Sydney Thai ◽  
Molly Aldridge ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Literature Review ◽  
Systematic Literature Review ◽  
A Priori ◽  
Risk Of Bias ◽  
Treatment Burden ◽  
Eligibility Criteria ◽  
Registration Number ◽  
Epidemiology Studies

Abstract BackgroundCrohn’s disease (CD)-related rectovaginal fistulas (RVFs) and anovaginal fistulas (AVFs) are rare, debilitating conditions that present a substantial disease and treatment burden for women. This systematic literature review (SLR) assessed the burden of Crohn’s-related RVF and AVF, summarizing evidence from observational studies and highlighting knowledge gaps.MethodsThis SLR identified articles in PubMed and Embase that provide data and insight into the patient experience and disease burden of Crohn’s-related RVF and AVF. Two trained reviewers used pre-specified eligibility criteria to identify studies for inclusion and evaluate risk of bias using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool for observational studies.ResultsOf the 582 records identified, 316 full-text articles were assessed, and 16 studies met a priori eligibility criteria and were included. Few epidemiology studies were identified, with one study estimating the prevalence of RVF to be 2.3% in females with Crohn’s disease. Seven of 12 treatment pattern studies reported that patients had or required additional procedures before and/or after the intervention of interest, demonstrating a substantial treatment burden. Seven of 11 studies assessing clinical outcomes reported fistula healing rates between 50% and 75%, with varying estimates based on population and intervention.ConclusionsThis SLR reports the high disease and treatment burden of Crohn’s-related RVF and AVF and identifies multiple evidence gaps in this field. The literature lacks robust, generalizable data, and demonstrates a compelling need for substantial, novel research into these rare and debilitating sequelae of CD.RegistrationThe PROSPERO registration number for the protocol for this systematic literature review is CRD42020177732.

scholarly journals Ileal Adenocarcinoma with Liver Metastasis in Patient with Crohn’s Disease: A 9-Year Survival

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Jiten P. Kothadia ◽  
Deepa H. Nagaraju ◽  
Seymour Katz ◽  
Howard Bruckner ◽  
Steven H. Itzkowitz ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Liver Metastasis ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Poor Prognosis ◽  
Treatment Options ◽  
Small Bowel Adenocarcinoma ◽  
Advanced Stage ◽  
Advanced Malignancies ◽  
Promising Treatment

Small bowel adenocarcinoma is a rare but well-known complication of Crohn’s disease. The diagnosis of small bowel adenocarcinoma remains difficult since its presentation is highly variable and mimics active or obstructive Crohn’s disease. The diagnosis is often delayed and typically detected only at surgery in an advanced stage with a poor prognosis. We report a case of metastatic ileal adenocarcinoma in a patient with Crohn’s disease with prolonged survival. Our case describes serial promising treatment options of these advanced malignancies and raises a possible role for checkpoint immunotherapy.

Recommendations for identifying Crohn’s disease patients with poor prognosis

2013 ◽  
Vol 9 (1) ◽  
pp. 65-76 ◽  
Author(s):  
Pal Miheller ◽  
Lajos S Kiss ◽  
Mark Juhasz ◽  
Michael Mandel ◽  
Peter L Lakatos
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Poor Prognosis ◽  
Patients With Poor Prognosis
Sign in / Sign up

Export Citation Format

Share Document