Apelin-13 Protects the Brain Against Ischemic Reperfusion Injury and Cerebral Edema in a Transient Model of Focal Cerebral Ischemia

2012 ◽  
Vol 48 (1) ◽  
pp. 201-208 ◽  
Author(s):  
Mehdi Khaksari ◽  
Nahid Aboutaleb ◽  
Farinaz Nasirinezhad ◽  
Abedin Vakili ◽  
Zahra Madjd
Keyword(s):  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Cerebral Edema ◽  
Focal Cerebral Ischemia ◽  
Ischemic Reperfusion Injury ◽  
Transient Model ◽  
Ischemic Reperfusion ◽  
The Brain

Hydrogen Sulfide Protects the Brain Against Ischemic Reperfusion Injury in a Transient Model of Focal Cerebral Ischemia

2014 ◽  
Vol 54 (2) ◽  
pp. 264-270 ◽  
Author(s):  
Sevda Gheibi ◽  
Nahid Aboutaleb ◽  
Mehdi Khaksari ◽  
Hamid Kalalian-Moghaddam ◽  
Abedin Vakili ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Focal Cerebral Ischemia ◽  
Ischemic Reperfusion Injury ◽  
Transient Model ◽  
Ischemic Reperfusion ◽  
The Brain

Apelin-13 Inhibits Apoptosis of Cortical Neurons Following Brain Ischemic Reperfusion Injury in a Transient Model of Focal Cerebral Ischemia

2013 ◽  
Vol 20 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Nahid Aboutaleb ◽  
Hamid Kalalianmoghaddam ◽  
Sanaz Eftekhari ◽  
Ali Shahbazi ◽  
Hadi Abbaspour ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Reperfusion Injury ◽  
Cortical Neurons ◽  
Focal Cerebral Ischemia ◽  
Ischemic Reperfusion Injury ◽  
Transient Model ◽  
Ischemic Reperfusion

scholarly journals Lipid Emulsion Improves Functional Recovery in an Animal Model of Stroke

2020 ◽  
Vol 21 (19) ◽  
pp. 7373
Author(s):  
Motomasa Tanioka ◽  
Wyun Kon Park ◽  
Joohyun Park ◽  
Jong Eun Lee ◽  
Bae Hwan Lee
Keyword(s):  
Reperfusion Injury ◽  
Signaling Pathway ◽  
Lipid Emulsion ◽  
Glycogen Synthase ◽  
Wnt Signaling Pathway ◽  
Sodium Pentobarbital ◽  
Ischemic Reperfusion Injury ◽  
Neuroprotective Effects ◽  
Ischemic Reperfusion ◽  
The Brain

Stroke is a life-threatening condition that leads to the death of many people around the world. Reperfusion injury after ischemic stroke is a recurrent problem associated with various surgical procedures that involve the removal of blockages in the brain arteries. Lipid emulsion was recently shown to attenuate ischemic reperfusion injury in the heart and to protect the brain from excitotoxicity. However, investigations on the protective mechanisms of lipid emulsion against ischemia in the brain are still lacking. This study aimed to determine the neuroprotective effects of lipid emulsion in an in vivo rat model of ischemic reperfusion injury through middle cerebral artery occlusion (MCAO). Under sodium pentobarbital anesthesia, rats were subjected to MCAO surgery and were administered with lipid emulsion through intra-arterial injection during reperfusion. The experimental animals were assessed for neurological deficit wherein the brains were extracted at 24 h after reperfusion for triphenyltetrazolium chloride staining, immunoblotting and qPCR. Neuroprotection was found to be dosage-dependent and the rats treated with 20% lipid emulsion had significantly decreased infarction volumes and lower Bederson scores. Phosphorylation of Akt and glycogen synthase kinase 3-β (GSK3-β) were increased in the 20% lipid-emulsion treated group. The Wnt-associated signals showed a marked increase with a concomitant decrease in signals of inflammatory markers in the group treated with 20% lipid emulsion. The protective effects of lipid emulsion and survival-related expression of genes such as Akt, GSK-3β, Wnt1 and β-catenin were reversed by the intra-peritoneal administration of XAV939 through the inhibition of the Wnt/β-catenin signaling pathway. These results suggest that lipid emulsion has neuroprotective effects against ischemic reperfusion injury in the brain through the modulation of the Wnt signaling pathway and may provide potential insights for the development of therapeutic targets.

Assessment of Oxidative Status of the Brain and Blood Plasma in Rats with Modeled Focal Cerebral Ischemia/Reperfusion Injury

2017 ◽  
Vol 163 (2) ◽  
pp. 195-198 ◽  
Author(s):  
A. A. Devyatov ◽  
T. N. Fedorova ◽  
S. L. Stvolinskii ◽  
M. A. Belousova ◽  
O. S. Medvedev ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Blood Plasma ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Focal Cerebral Ischemia ◽  
Ischemia Reperfusion ◽  
Oxidative Status ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion Injury ◽  
The Brain

scholarly journals Сerebroprotective effect of some phenolic acids under conditions of experimental brain ischemia

2020 ◽  
Vol 7 (6) ◽  
pp. 332-339
Author(s):  
A. V. Voronkov ◽  
D. I. Pozdnyakov ◽  
S. A. Nigaryan
Keyword(s):  
Cerebral Ischemia ◽  
Gallic Acid ◽  
Phenolic Acids ◽  
Cerebral Edema ◽  
Focal Cerebral Ischemia ◽  
Lactate Concentration ◽  
Edema Formation ◽  
Reference Drug ◽  
Male Wistar Rats ◽  
The Brain

The aim of the study was to evaluate the cerebroprotective effect of some phenolic acids under the conditions of experimental cerebral ischemia in rats.Materials and methods. The experiment was conducted on male Wistar rats weighing 220–240 g. Focal cerebral ischemia was modeled by irreversible right-sided thermocoagulation of the middle cerebral artery under chloral hydrate anesthesia (350 mg/kg, intraperitoneally). The experimental compounds (4-hydroxy-3.5-di-tert-butyl cinnamic acid, caffeic acid and gallic acid 100 mg/kg each compound) and a reference drug (Mexicor – 100 mg/kg) were administered intragastrically next day after the surgery and then for three daysrunning. The effect of the test-compounds on the cognitive functions of the rats was evaluated by CRPA and TEA tests. The influence of the compounds on the changes in the concentration of lactate, pyruvate, homocysteine, as well as the degree of cerebral edema formation and necrosis of the brain tissue, were studied.Results. In the study, it has been established that against the background of the focal cerebral ischemia, the administration of caffeic, 4-hydroxy-3,5-di-tert-butylcinnamic and gallic acid, contributed to the preservation of a memorable trace in rats, as well as a decrease in lactate concentration (by 40.37% (p<0.05), 151.26% (p<0.05), 48.02% (p<0.05)) and pyruvate (by 96.6,% (p<0.05), 38, 78% (p<0.05), 33.3% (p<0.05)), homocysteine (by 59.6% (p<0.05), 102.18% (p<0.05), 28.8% (p<0.05)), аnecrosis zone (by 122.79% (p<0.05), 165.11% (p<0.05), 12.38% (p<0,05)) and cerebral edema (by 10.47% (p<0.05), 11.08% (p<0.05), 9.92% (p<0.05)) relative to the NC group of rats.Conclusion. The obtained data indicate the possibility of further detailed investigation of the cerebroprotective effect of 4-hydroxy-3,5-di-tert-butylcinnamic, caffeic and gallic acids.

scholarly journals Synergic effect of combined cyclosporin and melatonin protects the brain against acute ischemic reperfusion injury

2021 ◽  
Vol 136 ◽  
pp. 111266
Author(s):  
Kuan-Hung Chen ◽  
Han-Tan Chai ◽  
Chih-Hung Chen ◽  
Chi-Ruei Huang ◽  
John Y. Chiang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Synergic Effect ◽  
Ischemic Reperfusion Injury ◽  
Ischemic Reperfusion ◽  
The Brain

The Effect of C1 Esterase Inhibitor on Ischemic Reperfusion Injury in Rat Epigastric Skin Flaps: Preliminary Results

2014 ◽  
Vol 30 (S 01) ◽  
Author(s):  
Inmaculada Jurado ◽  
Alberto Rodríguez ◽  
Carmen Vázquez ◽  
Víctor Velasco ◽  
Víctor Turrión ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Skin Flaps ◽  
Ischemic Reperfusion Injury ◽  
Preliminary Results ◽  
C1 Esterase Inhibitor ◽  
Ischemic Reperfusion ◽  
Esterase Inhibitor
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