Glial Cell-Derived Neurotrophic Factor Attenuates Neuropathic Pain in a Mouse Model of Chronic Constriction Injury: Possible Involvement of E-cadherin/p120ctn Signaling

2014 ◽  
Vol 54 (2) ◽  
pp. 156-163 ◽  
Author(s):  
Cunjin Wang ◽  
Hongjun Wang ◽  
Jun Pang ◽  
Li Li ◽  
Suming Zhang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Mouse Model ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Chronic Constriction Injury ◽  
E Cadherin

scholarly journals HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain

2003 ◽  
Vol 8 (3) ◽  
pp. 367-375 ◽  
Author(s):  
Shuanglin Hao ◽  
Marina Mata ◽  
Darren Wolfe ◽  
Shaohua Huang ◽  
Joseph C Glorioso ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Gene Transfer ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Antiallodynic Effect

scholarly journals Decreased expression of glial cell line-derived neurotrophic factor signaling in rat models of neuropathic pain

2003 ◽  
Vol 140 (7) ◽  
pp. 1252-1260 ◽  
Author(s):  
Masatoshi Nagano ◽  
Atsushi Sakai ◽  
Naoki Takahashi ◽  
Masahiro Umino ◽  
Koichi Yoshioka ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Rat Models ◽  
Neurotrophic Factor Signaling

scholarly journals Glial Cell Line-Derived Neurotrophic Factor Family Ligands, Players at the Interface of Neuroinflammation and Neuroprotection: Focus Onto the Glia

2021 ◽  
Vol 15 ◽  
Author(s):  
Anastasiia Kotliarova ◽  
Yulia A. Sidorova
Keyword(s):  
Neuropathic Pain ◽  
Immune System ◽  
Small Molecules ◽  
Cell Line ◽  
Glial Cell ◽  
Glial Cells ◽  
Neurotrophic Factor ◽  
Neuronal Cells ◽  
The Body ◽  
Neuronal Populations

Well-known effects of neurotrophic factors are related to supporting the survival and functioning of various neuronal populations in the body. However, these proteins seem to also play less well-documented roles in glial cells, thus, influencing neuroinflammation. This article summarizes available data on the effects of glial cell line derived neurotrophic factor (GDNF) family ligands (GFLs), proteins providing trophic support to dopaminergic, sensory, motor and many other neuronal populations, in non-neuronal cells contributing to the development and maintenance of neuropathic pain. The paper also contains our own limited data describing the effects of small molecules targeting GFL receptors on the expression of the satellite glial marker IBA1 in dorsal root ganglia of rats with surgery- and diabetes-induced neuropathy. In our experiments activation of GFLs receptors with either GFLs or small molecule agonists downregulated the expression of IBA1 in this tissue of experimental animals. While it can be a secondary effect due to a supportive role of GFLs in neuronal cells, growing body of evidence indicates that GFL receptors are expressed in glial and peripheral immune system cells. Thus, targeting GFL receptors with either proteins or small molecules may directly suppress the activation of glial and immune system cells and, therefore, reduce neuroinflammation. As neuroinflammation is considered to be an important contributor to the process of neurodegeneration these data further support research efforts to modulate the activity of GFL receptors in order to develop disease-modifying treatments for neurodegenerative disorders and neuropathic pain that target both neuronal and glial cells.

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