A clinical analysis of 37 cases with lymphoepithelial carcinoma of the major salivary gland treated by surgical resection and postoperative radiotherapy: a single institution study

e16045 Background: MSGTs are rare, biologically diverse cancers. Registry data and large series suggest 5-year OS exceeding 50%, superior to historical data and attributed to postoperative radiation (pXRT). Hypothesizing OS has remained poor despite modern therapy, we reviewed our cancer registry (OHSUCR), which began collecting data on MSGTs in 1995. Methods: We interrogated the OHSUCR for pts with MSGTs (WHO classification) and obtained data on age, sex, race, AJCC stage, histology, primary site, surgery, pXRT. OS was estimated using the Kaplan Meier (KM) method. The log rank test was used to compare OS among pts treated with and without pXRT, and those diagnosed between 1995-2000, 2001-2005, and 2005-present. Results: 110 pts with MSGTs were entered into the OHSUCR from 5/1996 to 5/2011. The median age was 60 (range 10-90), 65 (59%) were male, and 106 (96%) were white. The primary site was: 101 (92%) parotid, 3 (3%) unspecified major salivary gland, 4 (3%) submandibular gland, and 2 (2%) minor salivary gland. MSGT histologies were: 41 (37%) mucoepidermoid carcinoma, 24 (22%) adenoid cystic carcinoma, 21 (19%) adenocarcinoma, 12 (11%) acinar cell carcinoma, 5 (4%) carcinoma ex pleomorphic adenoma, 3 (3%) epithelial-myoepithelial carcinoma, 1 (1%) undifferentiated carcinoma, 1 (1%) small cell carcinoma, 1(1%) salivary duct carcinoma, 1 (1%) carcinosarcoma. AJCC Stage was: I in 29, (26%) II in 20 (18%), III in 16 (15%), IV in 45 (41%). 102 (96%) underwent surgical resection, 73 (66%) pXRT. 89 (81%) pts were rendered disease free, although 23 (21%) eventually recurred, 20 in distant sites. At the time of analysis 57 (52%) pts were alive and disease free. With a median follow up of 30 months (range 1 to 165), the 5 year KM OS for the entire cohort is 46%. Median survival was not influenced by pXRT (p=0.93) or period of diagnosis (1995-2000, 2001-2005, or 2005-present; p=0.83). Conclusions: In this large single institution series, pts with MSGT remain at high risk for mortality despite routine administration of pXRT. Distant metastasis is the most common pattern of failure indicating a clear unmet need for improved systemic therapy for MSGTs.

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CLINICAL ANALYSIS OF MAJOR SALIVARY GLAND CANCER IN NIIGATA PREFECTURE FOR 14 YEARS, 154 CASES.

Toukeibu Gan ◽

10.5981/jjhnc.31.95 ◽

2005 ◽

Vol 31 (1) ◽

pp. 95-99 ◽

Cited By ~ 3

Author(s):

Yuka MORITA ◽

Katsuro SATO ◽

Hideyuki HANAZAWA ◽

Jun WATANABE ◽

Yuichiro SATO ◽

...

Keyword(s):

Salivary Gland ◽

Clinical Analysis ◽

Salivary Gland Cancer ◽

Major Salivary Gland ◽

Niigata Prefecture

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Outcomes and prognostic factors for major salivary gland carcinoma following postoperative radiotherapy

Oral Oncology ◽

10.1016/j.oraloncology.2015.11.023 ◽

2016 ◽

Vol 54 ◽

pp. 75-80 ◽

Cited By ~ 21

Author(s):

Ali Hosni ◽

Shao Hui Huang ◽

David Goldstein ◽

Wei Xu ◽

Biu Chan ◽

...

Keyword(s):

Salivary Gland ◽

Prognostic Factors ◽

Postoperative Radiotherapy ◽

Major Salivary Gland ◽

Salivary Gland Carcinoma ◽

Gland Carcinoma

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A series Cases study of Carcinomas derived from myoepithelial cells in head and neck regions

10.21203/rs.3.rs-28116/v1 ◽

2020 ◽

Author(s):

Danni Cheng ◽

Yufang Rao ◽

Ke Qiu ◽

Jianqing Qiu ◽

Yijun Dong ◽

...

Keyword(s):

Head And Neck ◽

Surgical Resection ◽

Postoperative Radiotherapy ◽

Surgical Excision ◽

Myoepithelial Cells ◽

Single Institution ◽

Complete Surgical Excision ◽

The Mean ◽

Systemic Therapies

Abstract Background and Objectives: Carcinomas derived from myoepithelial cells in head and neck regions (CMCHN) are rare. The aim of this study was to demonstrate the clinical behaviors and treatment outcomes of these tumors.Methods: A retrospective review of fifteen CMCHN cases between 2002 and 2019 in a single institution was performed. Results: All of the fifteen patients (100%) underwent primary surgical resection. Eleven patients (73.3%) received conventional postoperative radiotherapy and four (26.7%) received systemic chemotherapy. Consequently, six patients (40%) had frequently recurrence after surgical resection, and seven patients (46.7%) received second or even third operations. Up to the time of last follow-up, only one patient died and the mean survival time was 15.8 years.Conclusions: Currently, complete surgical excision with or without systemic therapy is preferred, but it has limited efficacy on reducing the risk of recurrence. Thus, more effective systemic therapies are required and the researches on the mechanism of CMCHN recurrence should be encouraged.

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Prognostic factors in postoperative radiotherapy in salivary gland carcinoma: A single institution experience from Turkey

Indian Journal of Cancer ◽

10.4103/0019-509x.197721 ◽

2016 ◽

Vol 53 (2) ◽

pp. 274 ◽

Cited By ~ 2

Author(s):

M Kandaz ◽

G Soydemir ◽

Z Bahat ◽

E Canyılmaz ◽

A Yöney

Keyword(s):

Salivary Gland ◽

Prognostic Factors ◽

Postoperative Radiotherapy ◽

Salivary Gland Carcinoma ◽

Single Institution ◽

Gland Carcinoma

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124: Assessing Predictors of Locoregional Failure Following Surgical Resection of Non-Metastatic Salivary Gland Carcinoma and The Role of Postoperative Radiotherapy

Radiotherapy and Oncology ◽

10.1016/s0167-8140(20)31016-1 ◽

2020 ◽

Vol 150 ◽

pp. S54

Author(s):

Adrian Cozma ◽

Fatima Alfaraj ◽

Jelena Lukovic ◽

Jie Su ◽

Wei Xu ◽

...

Keyword(s):

Salivary Gland ◽

Surgical Resection ◽

Postoperative Radiotherapy ◽

Salivary Gland Carcinoma ◽

Locoregional Failure ◽

Gland Carcinoma

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Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series

Sao Paulo Medical Journal ◽

10.1590/s1516-31802006000100006 ◽

2006 ◽

Vol 124 (1) ◽

pp. 26-30 ◽

Cited By ~ 20

Author(s):

Alfio José Tincani ◽

André Del Negro ◽

Priscila Pereira Costa Araújo ◽

Hugo Kenzo Akashi ◽

Antonio Santos Martins ◽

...

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Postoperative Radiotherapy ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Clinical Staging ◽

Major Salivary Gland ◽

Gland Tumor ◽

Adenoid Cystic

CONTEXT AND OBJECTIVE: Salivary gland tumor management requires long-term follow-up because of tumor indolence and possible late recurrence and distant metastasis. Adenoid cystic carcinoma (ACC) accounts for 10-15% of such tumors. The aim here was to evaluate surgical and clinical management, staging and follow-up of ACC patients in one academic institution. DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas. METHODS: Data on 21 patients treated between 1993 and 2003 were reviewed. Management utilized clinical staging, histology and imaging. Major salivary gland tumor extent was routinely assessed by preoperative ultrasonography. Diagnosis, surgery type, margin type (negative/positive), postoperative radiotherapy and recurrence (presence/absence) were evaluated. RESULTS: There were eleven major salivary gland tumors (52.3%), seven submandibular and four parotid. Ten patients (47.7%) had minor salivary gland ACC (all in palate), while the submandibular was the most frequently affected major one. Diagnoses were mostly via fine-needle aspiration (FNA) and incision biopsy. Frozen sections were used for six patients. There was good ultrasound/FNA correlation. Sixteen (76%) had postoperative radiotherapy. One (4.7%) died from ACC and five now have recurrent disease: three (14.2%) locoregional and two (9.5%) distant metastases. CONCLUSION: Adenoid cystic carcinoma has locally aggressive behavior. In 21 cases, of ACC, the facial nerve was preserved in all except in the few with gross tumor involvement. Treatment was defined from physical examination, imaging, staging and histology.

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