Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

2014 ◽  
Vol 51 (2) ◽  
pp. 571-590 ◽  
Author(s):  
Ana I. Plácido ◽  
Catarina R. Oliveira ◽  
Paula I. Moreira ◽  
Cláudia Maria F. Pereira
Keyword(s):  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Brain Endothelial Cells ◽  
Amyloidogenic Processing

The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis

2003 ◽  
Vol 87 (1) ◽  
pp. 248-256 ◽  
Author(s):  
Donat Kögel ◽  
Robert Schomburg ◽  
Tina Schürmann ◽  
Claus Reimertz ◽  
Hans-Georg König ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Amyloid Precursor Protein ◽  
Pc12 Cells ◽  
Precursor Protein ◽  
Induced Apoptosis

scholarly journals Brain Endothelial Cells Produce Amyloid β from Amyloid Precursor Protein 770 and Preferentially Secrete theO-Glycosylated Form

2010 ◽  
Vol 285 (51) ◽  
pp. 40097-40103 ◽  
Author(s):  
Shinobu Kitazume ◽  
Yuriko Tachida ◽  
Masaki Kato ◽  
Yoshiki Yamaguchi ◽  
Takashi Honda ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Brain Endothelial Cells

The role of C-terminus of amyloid precursor protein under endoplasmic reticulum stress

2007 ◽  
Vol 58 ◽  
pp. S175
Author(s):  
Keita Takahashi ◽  
Tetsuhiro Niidome ◽  
Takeshi Kihara ◽  
Hachiro Sugimoto
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
C Terminus

scholarly journals A Splice Variant of β-Secretase Deficient in the Amyloidogenic Processing of the Amyloid Precursor Protein

2001 ◽  
Vol 276 (15) ◽  
pp. 12019-12023 ◽  
Author(s):  
Ursula Bodendorf ◽  
Frauke Fischer ◽  
Dale Bodian ◽  
Gerd Multhaup ◽  
Paolo Paganetti
Keyword(s):  
Endoplasmic Reticulum ◽  
Amyloid Precursor Protein ◽  
Secretory Pathway ◽  
Senile Plaques ◽  
Precursor Protein ◽  
Type I ◽  
Human Pancreas ◽  
Amino Acid Region ◽  
Amyloidogenic Processing ◽  
Main Component

β-Secretase (BACE) initiates the amyloidogenic processing of the amyloid precursor protein leading to the generation of the β-amyloid, the main component of Alzheimer's disease senile plaques. BACE is a type I transmembrane aspartyl protease of 501 amino acids. Here we describe a novel BACE mRNA lacking 132 base pairs that is expressed in the pancreas but not in the brain. Sequence alignment indicates that the deleted fragment matches the terminal two-thirds of exon 3. The new BACE variant is short of a 44-amino acid region located between the two catalytic aspartyl residues. Accordingly, a 50-kDa form of BACE (BACE457) is detected in the human pancreas. When expressed in cells, BACE457 colocalizes with the marker for the endoplasmic reticulum BiP. Moreover, BACE457 remains in a proenzymatic and endoglycosidase H-sensitive state, suggesting that its transport along the secretory pathway is blocked at the level of the endoplasmic reticulum. Notably, this novel form of BACE does not contribute to the processing of the amyloid precursor protein. Our findings suggest that tissue-specific splicing of the BACE mRNA may explain the observation that in the human pancreas robust transcription of the BACE gene does not translate into recovered enzymatic activity.

P3-234: Brain endothelial cells produce amyloid-β from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form

2011 ◽  
Vol 7 ◽  
pp. S590-S590
Author(s):  
Yuriko Tachida ◽  
Masaki Kato ◽  
Yoshiki Yamaguchi ◽  
Takashi Honda ◽  
Yasuhiro Hashimoto ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Brain Endothelial Cells

scholarly journals Impact of polymer-modified gold nanoparticles on brain endothelial cells: exclusion of endoplasmic reticulum stress as a potential risk factor

2016 ◽  
Vol 10 (9) ◽  
pp. 1341-1350 ◽  
Author(s):  
Laura Anspach ◽  
Ronald E. Unger ◽  
Christoph Brochhausen ◽  
Matthew I. Gibson ◽  
Harm-Anton Klok ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Risk Factor ◽  
Endoplasmic Reticulum Stress ◽  
Potential Risk ◽  
Potential Risk Factor ◽  
Brain Endothelial Cells
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