Neutrophil Lymphocyte Ratio: A Predictor of Disease Severity in Nasal Polyposis and Allergic Fungal Rhinosinusitis

2020 ◽  
Author(s):  
Anand Subash ◽  
Rijuneeta Gupta ◽  
Ashok Gupta ◽  
Sandeep Bansal ◽  
Abhijeet Singh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Nasal Polyposis ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis

Sinonasal Surfactant Protein A1, A2, and D Gene Expression in Cystic Fibrosis: A Preliminary Report

2007 ◽  
Vol 137 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Bradford A. Woodworth ◽  
Rachel Wood ◽  
John E. Baatz ◽  
Rodney J. Schlosser
Keyword(s):  
Gene Expression ◽  
Cystic Fibrosis ◽  
Nasal Polyposis ◽  
Quantitative Polymerase Chain Reaction ◽  
Surfactant Protein ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Novel Treatment ◽  
Polymerase Chain

OBJECTIVE: To measure alterations in SPA1, A2, and D gene expression in various forms of inflammatory chronic rhinosinusitis (CRS). STUDY DESIGN AND SETTING: Sinus mucosal biopsies were performed in patients with allergic fungal rhinosinusitis (AFS), CRS with nasal polyposis, cystic fibrosis (CF), and controls. SP mRNA was measured with quantitative polymerase chain reaction. RESULTS: Patients with CF (n = 4) showed significantly increased SPA1 (82-fold), SPA2 (100-fold), and SPD (47-fold) mRNA ( P < 0.05) when compared with controls (n = 5). Patients with CRS with nasal polyposis (n = 5) also demonstrated elevated SPA1 (27-fold), SPA2 (13-fold), and SPD (13-fold). Patients with AFS (n = 7) had increased SPA1 (5-fold), SPA2 (9-fold), and SPD (17-fold), but were not statistically significant. CONCLUSION: SPA1, A2, and D are upregulated in various forms of CRS, but are significantly elevated in cystic fibrosis CRS. SIGNIFICANCE: Understanding the role of SPs in CRS will help develop novel treatment approaches for sinonasal pathoses.

scholarly journals Nasal Polyposis and Fungal Schizophyllum Commune Infection: A Case Report

2011 ◽  
Vol 54 (2) ◽  
pp. 83-86 ◽  
Author(s):  
Aleksandar Perić ◽  
Danilo Vojvodić ◽  
Lidija Zolotarevski ◽  
Aneta Perić
Keyword(s):  
Rare Case ◽  
Nasal Polyps ◽  
Nasal Polyposis ◽  
Histopathological Examination ◽  
Schizophyllum Commune ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Fungal Hyphae ◽  
Oral Itraconazole ◽  
Basidiomycete Fungus

We present a rare case of eosinophilic fungal rhinosinusitis with nasal polyps in a 32-year-old woman caused by basidiomycete fungusSchizophyllum commune. Diagnosis was done by the endoscopic nasal examination, computed tomography (CT) of the paranasal sinuses, the histopathological examination of polyps, the presence of eosinophils and fungal hyphae in nasal mucus and by the detection ofS. communeby culture. The patient was successfully treated by combination of oral itraconazole and topical corticosteroid therapy combined with surgery. The pathogenesis and diagnosis of allergic fungal rhinosinusitis are also discussed.

scholarly journals Prognostic Role of Neutrophil to Lymphocyte Ratio in COVID-19 Patients: Still Valid in Patients That Had Started Therapy?

2021 ◽  
Vol 9 ◽  
Author(s):  
Monica Gelzo ◽  
Sara Cacciapuoti ◽  
Biagio Pinchera ◽  
Annunziata De Rosa ◽  
Gustavo Cernera ◽  
...  
Keyword(s):  
Disease Severity ◽  
Predictive Marker ◽  
Predictive Markers ◽  
Neutrophil To Lymphocyte Ratio ◽  
Disease Stage ◽  
Prognostic Role ◽  
Clinical Expression ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

COVID-19 may appear with a widely heterogeneous clinical expression. Thus, predictive markers of the outcome/progression are of paramount relevance. The neutrophil/lymphocyte ratio (NLR) has been suggested as a good predictive marker of disease severity and mortality. Accordingly, we found that NLR significantly increased in parallel with the WHO severity stage in COVID-19 patients during the Ist wave (March-May 2020; n = 49), due to the significant reduction of lymphocyte and the significant increase of neutrophil in severe COVID-19 patients. While, we did not observe significant differences of NLR between the WHO severity stage among COVID-19 patients of the IInd wave (September 2020-April 2021; n = 242). In these patients, the number of lymphocytes and neutrophils did not change significantly between patients of different severity subgroups. This difference likely depends on the steroids therapy that the patients of the IInd wave performed before hospitalization while most patients of the Ist wave were hospitalized soon after diagnosis. This is also confirmed by serum interleukin (IL)-6 and myeloperoxidase (MPO) that gradually increased with the disease stage in patients of the Ist wave, while such biomarkers (whose production is inhibited by steroids) did not show differences among patients of the IInd wave in different stages. Thus, the NLR could be tested at diagnosis in naïve patients before starting therapies.

Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: A promising marker in predicting disease severity

2012 ◽  
Vol 36 (5) ◽  
pp. 491-497 ◽  
Author(s):  
Serkan Torun ◽  
Bilge Demirel Tunc ◽  
Burak Suvak ◽  
Hakan Yildiz ◽  
Adnan Tas ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Severity ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Utility of Neutrophil-Lymphocyte Ratio (NLR) as an Indicator of Disease Severity and Prognostic Marker among Patients with Covid-19 Infection in a Tertiary Care Centre in Bangalore – A Retrospective Study

2021 ◽  
Vol 8 (16) ◽  
pp. 1020-1024
Author(s):  
Ashwin Kulkarni ◽  
Divya Prabhu ◽  
Likitesh A.B. ◽  
Anil Kumar T ◽  
Varun Vinayak P. Rao ◽  
...  
Keyword(s):  
Retrospective Study ◽  
High Resolution ◽  
Disease Severity ◽  
Severity Score ◽  
Computerised Tomography ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Mild Disease ◽  
Markers Of Inflammation ◽  
D Dimer

BACKGROUND The infection caused due to novel coronavirus 2 can cause wide spectrum of disease from asymptomatic mild disease to life threatening disease. The widespread inflammation is most likely the cause of the adverse outcomes. There are numerous markers of the inflammation which are used to identify the severity and prognosis of the disease. Neutrophil lymphocyte ratio (NLR) is one such marker which is easily available and feasible in all the hospital settings. This study intended to evaluate the NLR as a marker of disease severity and prognosis, in those with Covid-19. METHODS This was a retrospective study to determine the utility of NLR as a marker of severity and prognosis among patients with Covid disease. Medical records of 60 patients admitted with mild to moderate Covid-19 disease were reviewed and relevant data was retrieved. The NLR at admission and 72 hours later was noted. High resolution computerised tomography was done and computerised tomography severity score (CT-SS) was calculated. The outcomes of these patients were noted. RESULTS Mean NLR at admission in mild disease was 5.6 and in moderate disease was 9.2. This difference was found to be statistically significant. It was also seen that NLR had a positive co-relation with CT severity score, duration of hospital stay, Creactive protein (CRP) and D-dimer. For predicting mortality, NLR with cut off of 6.6 had a sensitivity of 100 % and a specificity of 66.07 %. CRP with cut off of 6.8 had sensitivity of 100 %, specificity of 76.79 %. D-dimer with cut off of 1.6 had specificity of 78.58 %. For predicting severity, NLR with cut off of 6.6 had sensitivity of 75 % and specificity of 80 %. CRP with cut off of 7.9 had sensitivity of 65 % and specificity of 100 %. D-dimer with cut off of 1.3, had sensitivity of 90 % and specificity of 97.5 %. CONCLUSIONS The study shows that neutrophil–lymphocyte ratio is a good indicator of disease severity and has prognostic significance in Covid-19. There is a positive correlation with high-resolution computed tomography (HRCT) chest score and other markers of inflammation among patients with Covid-19. Serial monitoring of NLR can be utilised as a surrogate to HRCT chest to determine disease severity whenever the latter is not available. This can ensure early intervention and help prevent mortality. KEYWORDS Neutrophil-Lymphocyte Ratio, Severity of Covid

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