scholarly journals Relationship between Neutrophil-Lymphocyte Ratio and Disease Severity in COVID-19 Patients in Isolation Ward of Dr. Soetomo General Teaching Hospital

2022 ◽  
Vol 16 (1) ◽  
Keyword(s):  
Disease Severity ◽  
Teaching Hospital ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Isolation Ward

scholarly journals Prognostic Role of Neutrophil to Lymphocyte Ratio in COVID-19 Patients: Still Valid in Patients That Had Started Therapy?

2021 ◽  
Vol 9 ◽  
Author(s):  
Monica Gelzo ◽  
Sara Cacciapuoti ◽  
Biagio Pinchera ◽  
Annunziata De Rosa ◽  
Gustavo Cernera ◽  
...  
Keyword(s):  
Disease Severity ◽  
Predictive Marker ◽  
Predictive Markers ◽  
Neutrophil To Lymphocyte Ratio ◽  
Disease Stage ◽  
Prognostic Role ◽  
Clinical Expression ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

COVID-19 may appear with a widely heterogeneous clinical expression. Thus, predictive markers of the outcome/progression are of paramount relevance. The neutrophil/lymphocyte ratio (NLR) has been suggested as a good predictive marker of disease severity and mortality. Accordingly, we found that NLR significantly increased in parallel with the WHO severity stage in COVID-19 patients during the Ist wave (March-May 2020; n = 49), due to the significant reduction of lymphocyte and the significant increase of neutrophil in severe COVID-19 patients. While, we did not observe significant differences of NLR between the WHO severity stage among COVID-19 patients of the IInd wave (September 2020-April 2021; n = 242). In these patients, the number of lymphocytes and neutrophils did not change significantly between patients of different severity subgroups. This difference likely depends on the steroids therapy that the patients of the IInd wave performed before hospitalization while most patients of the Ist wave were hospitalized soon after diagnosis. This is also confirmed by serum interleukin (IL)-6 and myeloperoxidase (MPO) that gradually increased with the disease stage in patients of the Ist wave, while such biomarkers (whose production is inhibited by steroids) did not show differences among patients of the IInd wave in different stages. Thus, the NLR could be tested at diagnosis in naïve patients before starting therapies.

Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: A promising marker in predicting disease severity

2012 ◽  
Vol 36 (5) ◽  
pp. 491-497 ◽  
Author(s):  
Serkan Torun ◽  
Bilge Demirel Tunc ◽  
Burak Suvak ◽  
Hakan Yildiz ◽  
Adnan Tas ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Severity ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Utility of Neutrophil-Lymphocyte Ratio (NLR) as an Indicator of Disease Severity and Prognostic Marker among Patients with Covid-19 Infection in a Tertiary Care Centre in Bangalore – A Retrospective Study

2021 ◽  
Vol 8 (16) ◽  
pp. 1020-1024
Author(s):  
Ashwin Kulkarni ◽  
Divya Prabhu ◽  
Likitesh A.B. ◽  
Anil Kumar T ◽  
Varun Vinayak P. Rao ◽  
...  
Keyword(s):  
Retrospective Study ◽  
High Resolution ◽  
Disease Severity ◽  
Severity Score ◽  
Computerised Tomography ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Mild Disease ◽  
Markers Of Inflammation ◽  
D Dimer

BACKGROUND The infection caused due to novel coronavirus 2 can cause wide spectrum of disease from asymptomatic mild disease to life threatening disease. The widespread inflammation is most likely the cause of the adverse outcomes. There are numerous markers of the inflammation which are used to identify the severity and prognosis of the disease. Neutrophil lymphocyte ratio (NLR) is one such marker which is easily available and feasible in all the hospital settings. This study intended to evaluate the NLR as a marker of disease severity and prognosis, in those with Covid-19. METHODS This was a retrospective study to determine the utility of NLR as a marker of severity and prognosis among patients with Covid disease. Medical records of 60 patients admitted with mild to moderate Covid-19 disease were reviewed and relevant data was retrieved. The NLR at admission and 72 hours later was noted. High resolution computerised tomography was done and computerised tomography severity score (CT-SS) was calculated. The outcomes of these patients were noted. RESULTS Mean NLR at admission in mild disease was 5.6 and in moderate disease was 9.2. This difference was found to be statistically significant. It was also seen that NLR had a positive co-relation with CT severity score, duration of hospital stay, Creactive protein (CRP) and D-dimer. For predicting mortality, NLR with cut off of 6.6 had a sensitivity of 100 % and a specificity of 66.07 %. CRP with cut off of 6.8 had sensitivity of 100 %, specificity of 76.79 %. D-dimer with cut off of 1.6 had specificity of 78.58 %. For predicting severity, NLR with cut off of 6.6 had sensitivity of 75 % and specificity of 80 %. CRP with cut off of 7.9 had sensitivity of 65 % and specificity of 100 %. D-dimer with cut off of 1.3, had sensitivity of 90 % and specificity of 97.5 %. CONCLUSIONS The study shows that neutrophil–lymphocyte ratio is a good indicator of disease severity and has prognostic significance in Covid-19. There is a positive correlation with high-resolution computed tomography (HRCT) chest score and other markers of inflammation among patients with Covid-19. Serial monitoring of NLR can be utilised as a surrogate to HRCT chest to determine disease severity whenever the latter is not available. This can ensure early intervention and help prevent mortality. KEYWORDS Neutrophil-Lymphocyte Ratio, Severity of Covid

scholarly journals Neutrophil-Lymphocyte Ratio as a Predictor of Disease Severity in Ulcerative Colitis

2013 ◽  
Vol 27 (1) ◽  
pp. 72-76 ◽  
Author(s):  
Mehmet Celikbilek ◽  
Serkan Dogan ◽  
Omer Ozbakır ◽  
Gökmen Zararsız ◽  
Hamit Kücük ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Severity ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Value of Neutrophil-Lymphocyte Ratio (NLR), Monocyte-Lymphocyte Ratio (MLR), Absolute Lymphocyte Count (ALC) and Procalcitonin in Patients in Covid-19 Monitoring (PDP) at Dr. Saiful Anwar Malang Hospital

2020 ◽  
Vol 40 (3) ◽  
Author(s):  
Umi Fatma Octavia ◽  
Iin Nur Chozin ◽  
Yani Jane Sugiri
Keyword(s):  
Infectious Disease ◽  
Medical Records ◽  
Lymphocyte Count ◽  
Absolute Lymphocyte Count ◽  
Shortness Of Breath ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Co Morbidity ◽  
Isolation Ward ◽  
Age Range

Background: The Covid-19 pandemic which is currently sweeping the world is an infectious disease that has only recently been identified and provides challenges for experts in dealing with and overcoming its spread. Fast and precise diagnostics are needed for the appropriate management of Covid-19. The value of the neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), absolute lymphocyte count (ALC) have been investigated for their potential and ability as a diagnostic and prognostic approach. In Indonesia alone the spread of Covid-19 is quite high and alarming. Evidence of characteristics and clinical manifestation of Covid-19 is imperative. Methods: This study was an observational analytic study of hematological laboratory parameters that measured the values of NLR, MLR, ALC, and procalcitonin in patients under Covid-19 monitoring. All data were obtained from the medical records of patients treated in the isolation ward of the emerging and re-emerging infectious disease at Dr. Saiful Anwar Hospital Malang. This study also compared these variables between groups of patients confirmed by Covid-19 and those that were not confirmed, in order to identify the characteristics of patients in Covid-19 monitoring at Dr. Saiful Anwar Hospital Malang. Results: From 40 study subjects, the average age of all subjects was 49.58 ± 16.42 years. The confirmed cases of Covid-19 tend to be younger compared to the unconfirmed, in the age range of 15-49 years . The majority of the sex of the study subjects were male, with the predominance of the female in the confirmed patient group. The most prominent complaints are coughing and shortness of breath, while the most common co-morbidity is hypertension. The NLR, MLR, ALC, and procalcitonin values of patients confirmed Covid-19 did not differ significantly from those unconfirmed. The length of stay between the two groups was 7.8 ± 2.44 days for Covid-19 confirmed patients and 5.65 ± 3.08 days for unconfirmed Covid-19 patients. Conclusion: The results of this study show that patients with suspicion of Covid-19 in Dr. Saiful Anwar Hospital Malang are dominated by young adults . There were no significant differences of NLR, MLR, ALC, and Procalcitonin in either confirmed and non-confirmed Covid-19 patients.

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