Prognostic Value of HPV Infection Assessed by p16 Immunohistochemistry and the Influence of Tobacco Usage in Oropharyngeal Cancers: Real World Scenario

2021 ◽  
Author(s):  
Sushmita Ghoshal ◽  
Chinna Babu Dracham ◽  
Archana Sundaram ◽  
Rajesh Kumar ◽  
Amanjit Bal ◽  
...  
Keyword(s):  
Real World ◽  
Prognostic Value ◽  
Hpv Infection ◽  
P16 Immunohistochemistry ◽  
Tobacco Usage

scholarly journals STK11 (LKB1) mutations in metastatic NSCLC: Prognostic value in the real world

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0238358 ◽  
Author(s):  
Norah J. Shire ◽  
Alyssa B. Klein ◽  
Asieh Golozar ◽  
Jenna M. Collins ◽  
Kathy H. Fraeman ◽  
...  
Keyword(s):  
Real World ◽  
Prognostic Value ◽  
The Real ◽  
Metastatic Nsclc

PO-128: HPV Infection in Head and Neck Cancer. Is P16 Immunohistochemistry a Reliable Surrogate Marker?

2013 ◽  
Vol 106 ◽  
pp. S54-S55
Author(s):  
F. Bussu ◽  
C. Parrilla ◽  
G. Delogu ◽  
M. Sali ◽  
N. Dinapoli ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Surrogate Marker ◽  
Hpv Infection ◽  
P16 Immunohistochemistry

scholarly journals Prognostic value of clinical staging according to TNM in patients with SCLC: a real-world SEER database analysis

2021 ◽  
pp. 100266
Author(s):  
Edurne Arriola ◽  
José Manuel Trigo Perez ◽  
Amparo Sanchez Gastaldo ◽  
Alejandro Navarro ◽  
Coral Perez ◽  
...  
Keyword(s):  
Real World ◽  
Prognostic Value ◽  
Clinical Staging ◽  
Seer Database ◽  
Database Analysis

scholarly journals Ancillary Studies in Determining Human Papillomavirus Status of Squamous Cell Carcinoma of the Oropharynx: A Review

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Richard L. Cantley ◽  
Eleonora Gabrielli ◽  
Francesco Montebelli ◽  
David Cimbaluk ◽  
Paolo Gattuso ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Significant Proportion ◽  
Hpv Infection ◽  
P16 Immunohistochemistry ◽  
Hpv Status ◽  
High Risk Hpv ◽  
Ancillary Studies

Squamous cell carcinoma (SCC) of the oral cavity and pharynx represents the sixth most common form of malignancy worldwide. A significant proportion of these cases are related to human papillomavirus (HPV) infection. In general, HPV-associated SCC is more commonly nonkeratinizing and poorly differentiated, whereas non-HPV-associated SCC is typically keratinizing and moderately differentiated. Nevertheless, significant overlap in morphology is seen between these two forms of SCC. The purpose of this paper is to highlight the utility of ancillary studies in the establishment of HPV status of oropharyngeal SCC, including p16 immunohistochemistry, high-risk HPV in situ hybridization, polymerase chain reaction, and newer HPV detection modalities.

Population-based p16 and HPV positivity rates in oropharyngeal cancer in Southeast Scotland

2015 ◽  
Vol 68 (10) ◽  
pp. 849-852 ◽  
Author(s):  
L A R Wells ◽  
E J Junor ◽  
B Conn ◽  
S Pattle ◽  
K Cuschieri
Keyword(s):  
Hpv Infection ◽  
Population Based ◽  
Papilloma Virus ◽  
P16 Immunohistochemistry ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Hpv Types ◽  
Positive Groups ◽  
Formalin Fixed ◽  
Cause Specific Survival

We assessed a population-based cohort of patients diagnosed with oropharyngeal squamous cell carcinoma in Southeast Scotland over 13 months. p16 and human papilloma virus (HPV) expression were determined, and correlated with stage, treatment, smoking and alcohol history, and disease outcomes. Retrospective analysis was performed on 60 patients. p16 immunohistochemistry and HPV genotyping were performed on formalin-fixed paraffin-embedded tissues. HPV infection (as defined by p16 positivity and/or HPV PCR positivity) was identified in 57% of samples, while dual positives were detected in 45% of cases. HPV16 was most prevalent of the HPV types and was associated with 90% of positive samples. Cause-specific 1-year and 2-year survivals were 82.5% and 78.2%, respectively. The p16-positive and HPV-positive groups demonstrated significantly increased cause-specific survival in comparison with their negative counterparts.

Prognostic value of mean platelet volume in non-small cell lung cancer: a real-world, registry-based study

2019 ◽  
Author(s):  
Kyriaki Cholidou ◽  
Nektarios Anagnostopoulos ◽  
Dimitra Grapsa ◽  
Ioannis Gkiozos ◽  
Eleni Kokkotou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Real World ◽  
Mean Platelet Volume ◽  
Prognostic Value ◽  
Small Cell ◽  
Small Cell Lung ◽  
Platelet Volume

scholarly journals 017 Microvolt T-wave Alternans (MTWA) testing in “real world” heart failure (HF): a study of prevalence and incremental prognostic value

Heart ◽  
2012 ◽  
Vol 98 (Suppl 1) ◽  
pp. A12.2-A12
Author(s):  
C E Jackson ◽  
R C Myles ◽  
I K Tsorlalis ◽  
J R Dalzell ◽  
J P Rocchiccioli ◽  
...  
Keyword(s):  
Heart Failure ◽  
Real World ◽  
Prognostic Value ◽  
T Wave ◽  
T Wave Alternans ◽  
Incremental Prognostic Value
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