Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis

2016 ◽  
Vol 10 (4) ◽  
pp. 606-615 ◽  
Author(s):  
Xueyuan Nian ◽  
Zhihui Xu ◽  
Yan Liu ◽  
Jianhong Chen ◽  
Xiaodong Li ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Failure ◽  
Chinese Population ◽  
Core Promoter ◽  
Meta Analysis ◽  
Basal Core Promoter ◽  
Chronic Liver Failure ◽  
Precore Region ◽  
B Virus

Association of hepatitis B virus subgenotypes and basal core promoter/precore region variants with the clinical features of patients with acute hepatitis

2008 ◽  
Vol 43 (7) ◽  
pp. 558-564 ◽  
Author(s):  
Kazuhiko Hayashi ◽  
Yoshiaki Katano ◽  
Yasushi Takeda ◽  
Takashi Honda ◽  
Masatoshi Ishigami ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Clinical Features ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Precore Region ◽  
B Virus

scholarly journals Prevalence of Mutations in Basal Core Promoter and Precore Region of Hepatitis B Virus in Vaccinated and Nonvaccinated Individuals of the Aboriginal Nicobarese Tribe of Car Nicobar Island, India

Intervirology ◽  
2014 ◽  
Vol 57 (6) ◽  
pp. 357-364 ◽  
Author(s):  
Haimanti Bhattacharya ◽  
Debdutta Bhattacharya ◽  
Muruganandam Nagarajan ◽  
Rajesh Reesu ◽  
Subarna Roy ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Promoter ◽  
Basal Core Promoter ◽  
Nicobar Island ◽  
Precore Region ◽  
B Virus

scholarly journals Prevalence of Hepatitis B Virus (HBV) Basal Core Promoter/Precore region molecular variants among HIV/HBV co-infected and HBV mono-infected patients in Ile-Ife, Nigeria

2020 ◽  
Author(s):  
Oluwadamilola Gideon Osasona ◽  
Lydia Boudarene ◽  
Opeoluwa Adewale-Fasoro ◽  
Uwem George ◽  
Judith Oguzie ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Phenotypic Diversity ◽  
Stop Codon ◽  
Core Promoter ◽  
Enzyme Linked Immunosorbent Assay ◽  
Basal Core Promoter ◽  
Double Mutation ◽  
Precore Region ◽  
B Virus

AbstractIntroductionEvolution of phenotypic diversity among viruses occurs as an escape mechanism against host immune pressure or drug selective pressure. Among HIV/HBV co-infected individuals, various HBV basal core promoter (BCP)/precore (PC) region molecular mutants had been reported with associated phenotypic defect in HBeAg production. The emergence of HBeAg negative variants of HBV in HIV co-infected individuals have profound implication on the diagnosis, management and prognosis of this subset of individuals. This includes delayed clearance of HBV, early development of adverse hepatic events such as liver cirrhosis and hepatocellular carcinoma. Currently, little is known about HBV BCP/PC region genomic heterogeneity in HIV/HBV co-infected patients in Nigeria. Therefore, this study was focussed on investigating evidence of precore/core region genomic variability among HIV/HBV co-infected patients in Nigeria.Materials and methodsA total of 40 patients (20 HIV/HBV co-infected and 20 HBV mono-infected samples) were enrolled into the study and subsequently tested for HBsAg, HBeAg and HBeAb using specific Enzyme-Linked Immunosorbent Assay (ELISA). The BCP/PC genome regions (nucleotides 1653-1959) were amplified using a nested PCR assay and then subjected to BCP/PC mutational analysis in genome sites affecting HBeAg expression especially at the BCP transcriptional and PC Translational stop codon sites.ResultsOverall, 5(83.3%) of the six exploitable sequences after analysis showed various BCP/PC mutations. Only 1(16.6%) sequence from an HIV/HBV co-infected patient had the BCP transcriptional (double mutation; A1762T/G1764A) mutant. Analysis of the PC translational stop codon showed 4 (66.6%) having the G1896A mutants while 33.3% (2) had G1899A mutants.ConclusionThis study has broadened the available evidence of BCP/PC region molecular mutants among HIV/HBV co-infected patients in Nigeria and assessed the difference of mutation prevalence in comparison with HBV mono-infected cohort. We therefore recommend that HIV/HBV co-infected patients be routinely screened for hepatitis B virus precore region mutants to improve their patient outcome.

HINT: a novel prognostic model for patients with hepatitis B virus-related acute-on-chronic liver failure

2018 ◽  
Vol 48 (7) ◽  
pp. 750-760 ◽  
Author(s):  
Daxian Wu ◽  
Zeyu Sun ◽  
Xiaoli Liu ◽  
Qunfang Rao ◽  
Wenqian Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Failure ◽  
Prognostic Model ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
B Virus
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