Extracellular vesicles from MDA-MB-231 breast cancer cells stimulated with insulin-like growth factor 1 mediate an epithelial–mesenchymal transition process in MCF10A mammary epithelial cells

2021 ◽  
Author(s):  
Elizabeth Leal-Orta ◽  
Javier Ramirez-Ricardo ◽  
Alejandra Garcia-Hernandez ◽  
Pedro Cortes-Reynosa ◽  
Eduardo Perez Salazar
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mammary Epithelial Cells ◽  
Transition Process ◽  
Mammary Epithelial ◽  
Mesenchymal Transition

Extracellular vesicles from women with breast cancer promote an epithelial-mesenchymal transition-like process in mammary epithelial cells MCF10A

Tumor Biology ◽  
2015 ◽  
Vol 36 (12) ◽  
pp. 9649-9659 ◽  
Author(s):  
Octavio Galindo-Hernandez ◽  
Cristina Gonzales-Vazquez ◽  
Pedro Cortes-Reynosa ◽  
Emmanuel Reyes-Uribe ◽  
Sonia Chavez-Ocaña ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Extracellular Vesicles ◽  
Epithelial Mesenchymal Transition ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Mesenchymal Transition

scholarly journals Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Joanna M Poczobutt ◽  
John Tentler ◽  
Xian Lu ◽  
Pepper J Schedin ◽  
Arthur Gutierrez-Hartmann
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Epithelial-mesenchymal transition sensitizes breast cancer cells to cell death via the fungus-derived sesterterpenoid ophiobolin A

2020 ◽  
Author(s):  
Keighley N. Reisenauer ◽  
Yongfeng Tao ◽  
Shuxuan Song ◽  
Saawan D. Patel ◽  
Alec Ingros ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Tumor Burden ◽  
Mammary Epithelial ◽  
Mesenchymal Transition ◽  
Human Mammary Epithelial ◽  
Necessary And Sufficient

AbstractThe epithelial-mesenchymal transition (EMT) imparts properties of cancer stem-like cells, including resistance to frequently used chemotherapy, necessitating the identification of molecules that induce cell death specifically in stem-like cells with EMT properties. Herein, we demonstrate that breast cancer cells enriched for EMT features are more sensitive to cytotoxicity induced by ophiobolin A (OpA), a sesterterpenoid natural product. Using a model of experimentally induced EMT in human mammary epithelial (HMLE) cells, we show that EMT is both necessary and sufficient for OpA sensitivity. Moreover, prolonged, sub-cytotoxic exposure to OpA is sufficient to reduce migration, sphere formation, and resistance to doxorubicin. OpA is well-tolerated in mice and treatment with OpA alone reduces tumor burden. These data identify a driver of EMT-driven cytotoxicity with significant potential for use either in combination with standard chemotherapy or for tumors enriched for EMT features.

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