Erratum to: Perceived Diabetes Task Competence Mediates the Relationship of Both Negative and Positive Affect with Blood Glucose in Adolescents with Type 1 Diabetes

Objective: As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities. Research Design and Methods: Participants aged <18 years with diabetes duration ≥1 year in the Type 1 Diabetes Exchange (T1DX, US, n=16,457) and Diabetes Prospective Follow-up (DPV, Germany, n=39,836) registries were categorized into lowest (Q1) to highest (Q5) SES quintiles. Multiple regression analyses compared the relationship of SES quintiles with diabetes technology use and HbA1c from 2010-2012 and 2016-2018. Results: HbA1c was higher in participants with lower SES (in 2010-2012 & 2016-2018, respectively: 8.0% & 7.8% in Q1 and 7.6% & 7.5% in Q5 for DPV; and 9.0% & 9.3% in Q1 and 7.8% & 8.0% in Q5 for T1DX). For DPV, the association between SES and HbA1c did not change between the two time periods, whereas for T1DX, disparities in HbA1c by SES increased significantly (p<0.001). After adjusting for technology use, results for DPV did not change whereas the increase in T1DX was no longer significant. Conclusions: Although causal conclusions cannot be drawn, diabetes technology use is lowest and HbA1c is highest in those of the lowest SES quintile in the T1DX and this difference for HbA1c broadened in the last decade. Associations of SES with technology use and HbA1c were weaker in the DPV registry.

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PREDICTION OF OCCURRENCE AND THE RELATIONSHIP OF AUTOIMMUNE DISEASES IN CHILDREN WITH TYPE 1 DIABETES

European Science Review ◽

10.29013/esr-19-5.6-41-43 ◽

2019 ◽

pp. 41-43

Author(s):

A. A. Sadirkhodjaeva ◽

D. T. Ashurova

Keyword(s):

Type 1 Diabetes ◽

Autoimmune Diseases ◽

Relationship Of ◽

The Relationship

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Sex difference in the relationship of calcium and magnesium excretion to glycaemic control in type 1 diabetes mellitus

Clinica Chimica Acta ◽

10.1016/s0009-8981(99)00040-6 ◽

1999 ◽

Vol 283 (1-2) ◽

pp. 119-128 ◽

Cited By ~ 23

Author(s):

Iain R. Brown ◽

Alasdair M. McBain ◽

John Chalmers ◽

Ian W. Campbell ◽

Ewan R. Brown ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycaemic Control ◽

Type 1 Diabetes Mellitus ◽

Sex Difference ◽

Calcium And Magnesium ◽

Magnesium Excretion ◽

Relationship Of ◽

The Relationship

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Evaluation of the relationship between short-term glycemic control and netrin-1, a urinary proximal tubular injury marker in children with type 1 diabetes

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2018-0373 ◽

2019 ◽

Vol 32 (8) ◽

pp. 851-856

Author(s):

Seyit Ahmet Uçaktürk ◽

Eda Mengen ◽

Selin Elmaoğulları ◽

Çiğdem Yücel ◽

Aslıhan A. Yılmaz ◽

...

Keyword(s):

Type 1 Diabetes ◽

Blood Glucose ◽

Early Period ◽

Tubular Damage ◽

Healthy Controls ◽

Tubular Injury ◽

Short Term ◽

Duration Of Diabetes ◽

The Relationship

Abstract Background Diabetic nephropathy (DN) is a significant cause of morbidity and mortality in young adults with type 1 diabetes (T1D). Microalbuminuria (MA) is generally considered as the earliest manifestation of DN. However, it has been shown that MA may be temporary and not reflect permanent renal failure. For this reason, sensitive markers are needed for the detection of kidney damage in the early period. Urinary tubular injury markers increase in the early period of diabetes. These tubular markers are rather indicators of acute renal damage. The objective of this study was to measure the urinary netrin-1 level, a marker of tubular injury in children with normoalbuminuric (NA) T1D, and to determine its relationship with short-term fluctuations in blood glucose using fructosamine levels. Methods Netrin-1 levels in spot urine samples from 82 children with T1D (median age 13.6 years) without MA or hypertension and from 59 healthy controls (median age 11.3 years) with a similar distribution of age and body mass index (BMI) were compared. The relationship of the netrin-1 levels with diabetes parameters such as fructosamine, hemoglobin A1c (HbA1c) or duration of diabetes was investigated. Results Urinary netrin-1 level was found to be higher in patients with T1D than in healthy controls (590 [interquartile range (IQR) = 811] pg/mg-creatinine [pg/mg-cr] and 396 [IQR = 742] pg/mg-cr, respectively) (p = 0.03). Urinary netrin-1 was found to correlate with HbA1c (p = 0.007, r = 0.320) and fructosamine (p = 0.04, r = 0.310) but not with average HbA1c in the last year (p = 0.14, r = −0.19), duration of diabetes (p = 0.83, r = 0.02) or other diabetes indices. Conclusions These results support the idea that tubular damage occurs early in the course of diabetes. However, the fact that netrin-1 is related to fructosamine and HbA1c but not to the duration of diabetes or average HbA1c in the last year may suggest that the tubular damage markers are affected by short-term fluctuations in blood glucose.

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