Clofarabine-based chemotherapy as a bridge to transplant in the setting of refractory or relapsed acute myeloid leukemia, after at least one previous unsuccessful salvage treatment containing fludarabine: a single institution experience

2017 ◽  
Vol 105 (6) ◽  
pp. 769-776 ◽  
Author(s):  
Alfredo Molteni ◽  
Marta Riva ◽  
Emanuele Ravano ◽  
Laura Marbello ◽  
Valentina Mancini ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Salvage Treatment ◽  
Single Institution ◽  
Bridge To Transplant ◽  
Relapsed Acute Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Salvage treatment for refractory or relapsed acute myeloid leukemia: a 10-year single-center experience

Clinics ◽  
2020 ◽  
Vol 75 ◽  
Author(s):  
Wellington Fernandes da Silva ◽  
Lidiane Inês da Rosa ◽  
Fernanda Salles Seguro ◽  
Douglas Rafaele Almeida Silveira ◽  
Israel Bendit ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Salvage Treatment ◽  
Single Center ◽  
Single Center Experience ◽  
Relapsed Acute Myeloid Leukemia ◽  
Acute Myeloid

scholarly journals Successful combination chemotherapy involving clofarabine, cyclophosphamide, and etoposide for pediatric relapsed acute myeloid leukemia: A case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110155
Author(s):  
Sachio Fujita ◽  
Ryosuke Matsuno ◽  
Naoko Kawabata ◽  
Yumiko Sugishita ◽  
Ryota Kaneko ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Allogeneic Bone Marrow Transplantation ◽  
Gemtuzumab Ozogamicin ◽  
Allogeneic Bone ◽  
Hematopoietic Stem ◽  
Positive Effects ◽  
Refractory Acute Myeloid Leukemia ◽  
Relapsed Acute Myeloid Leukemia ◽  
Acute Myeloid

Limited salvage chemotherapies are available for relapsed/refractory acute myeloid leukemia. Herein, we described successful reinduction chemotherapy, involving a combination of clofarabine, cyclophosphamide, and etoposide, in a 12-year-old male with relapsed acute myeloid leukemia prior to allogeneic bone marrow transplantation from his father. Although treatment with a combination of fludarabine, cytarabine, granulocyte colony-stimulating factor, idarubicin, and gemtuzumab ozogamicin had no positive effects, the aforementioned clofarabine-based chemotherapy induced complete remission and allowed the transplantation to go ahead. The abovementioned regimen may be useful for induction chemotherapy prior to hematopoietic stem cell transplantation for refractory/relapsed acute myeloid leukemia.

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