Clinical usefulness of diagnostic criteria for transplant-associated thrombotic microangiopathy

2020 ◽  
Vol 112 (5) ◽  
pp. 697-706 ◽  
Author(s):  
Ken Sagou ◽  
Nobuaki Fukushima ◽  
Shun Ukai ◽  
Miyo Goto ◽  
Kazutaka Ozeki ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Thrombotic Microangiopathy ◽  
Clinical Usefulness

The pathological challenge of establishing a precise diagnosis for pulmonary tumour thrombotic microangiopathy: identification of new diagnostic criteria

2019 ◽  
Vol 74 (6) ◽  
pp. 892-901 ◽  
Author(s):  
Naoko Sato ◽  
Takashi Tasaki ◽  
Hirotsugu Noguchi ◽  
Koji Irie ◽  
Toshiyuki Nakayama
Keyword(s):  
Diagnostic Criteria ◽  
Thrombotic Microangiopathy ◽  
Precise Diagnosis

scholarly journals Változások az őssejt-transzplantációhoz társult thromboticus microangiopathia diagnosztikus kritériumrendszerében

2017 ◽  
Vol 158 (27) ◽  
pp. 1043-1050
Author(s):  
Orsolya Horváth ◽  
Zoltán Prohászka ◽  
Krisztián Kállay ◽  
Csaba Kassa ◽  
Anita Stréhn ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Diagnostic Criteria ◽  
Cell Transplantation ◽  
Thrombotic Microangiopathy ◽  
Alternative Pathway ◽  
Hematological Parameters ◽  
Diagnostic Strategy ◽  
Hematopoietic Stem ◽  
Therapeutical Options

Abstract: Hematopoietic stem cell transplantation associated thrombotic microangiopathy is a multifactorial complication, and has variable incidence in study populations due to different diagnostic criteria. The diversity of activity parameters, like elevated laktát-dehidrogenáz, hematological parameters and kidney function are not specific variables after stem cell transplantation. Dysregulation of the classical and alternative pathway can play an important role in the pathomechanism of thrombotic microangiopathy, but the understanding of the role of complement activation under transplantation conditions requires further investigation. Monitoring of complement parameters, including terminal complement pathway activation complex during transplantation may help physicians to improve diagnostic strategy, to evaluate therapeutical options and to predict and follow up efficacy of complement blockade methods and supportive therapy. This review focuses on the development of diagnostic criteria and therapeutical options in thrombotic microangiopathy, and presents some preliminary findings while using different diagnostic criteria in pediatric patients. Orv Hetil. 2017; 158(27): 1043–1050.

A Symptom Based Approach to the Diagnosis of Schizophrenia*

1983 ◽  
Vol 28 (6) ◽  
pp. 484-486
Author(s):  
S. Packer ◽  
F. Engelsmann
Keyword(s):  
Diagnostic Criteria ◽  
Signs And Symptoms ◽  
Clinical Usefulness ◽  
Kappa Statistics ◽  
Point System ◽  
Schizophrenic Patients ◽  
Different Levels

This study reviews the attempts of Carpenter et al to develop valid diagnostic criteria of schizophrenia by means of a flexible 12 point system of signs and symptoms based on the IPSS. The authors applied the 12–point system to 67 inpatients and obtained different levels of certainty in identifying proportions of schizophrenic and non-schizophrenic patients: 80% of clinically diagnosed schizophrenic patients obtained 5 or more points. Kappa statistics revealed a 0.59 proportion of agreement in excess to chance between clinical and experimental diagnosis of schizophrenia, indicating the clinical usefulness of the 12 point system.

Posttransplant thrombotic microangiopathy: sensitivity of proposed new diagnostic criteria

Transfusion ◽  
2009 ◽  
Vol 49 (9) ◽  
pp. 1884-1889 ◽  
Author(s):  
Glen A. Kennedy ◽  
Shane Bleakley ◽  
Jason Butler ◽  
Kari Mudie ◽  
Natasha Kearey ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Thrombotic Microangiopathy

scholarly journals COVID-19 coagulopathy: is it disseminated intravascular coagulation?

2020 ◽  
Author(s):  
Marcel Levi ◽  
Toshiaki Iba
Keyword(s):  
Endothelial Cell ◽  
Diagnostic Criteria ◽  
Disseminated Intravascular Coagulation ◽  
Thrombotic Microangiopathy ◽  
Thromboembolic Disease ◽  
Cell Infection ◽  
Intravascular Coagulation

AbstractOne of the significant complications of severe COVID-19 infections is a coagulopathy that seems to be related to the occurrence of venous and arterial thromboembolic disease. The coagulation changes mimic but are not identical to disseminated intravascular coagulation (DIC). The vast majority of patients with COVID-19 do not meet the criteria for usual forms of DIC. In addition, there seem to be features of a strong local pulmonary thrombotic microangiopathy and direct endothelial cell infection and injury by the virus that affect the coagulopathic response to severe COVID-19. It seems COVID-19 leads to a distinct intravascular coagulation syndrome that may need separate diagnostic criteria.

Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

1973 ◽  
Vol 31 ◽  
pp. 404-405
Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Tumor Tissue ◽  
Soft Tissue Tumors ◽  
Clinical Usefulness ◽  
Electron Microscopic ◽  
Normal Cells ◽  
Electron Microscopic Autoradiography ◽  
Peritoneal Cells ◽  
Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

An adrenocortical oncocytoma with unusual mitochondrial inclusions and cytoplasmic crystals

1994 ◽  
Vol 52 ◽  
pp. 250-251
Author(s):  
W.T. Gunning ◽  
G.D. Haselhuhn ◽  
E.R. Phillips ◽  
S.H. Selman
Keyword(s):  
Adrenal Gland ◽  
Salivary Glands ◽  
Mitotic Activity ◽  
Diagnostic Criteria ◽  
Vascular Invasion ◽  
Benign Neoplasm ◽  
Benign Tumors ◽  
Nuclear Morphology ◽  
Case Presentation ◽  
Microscopic Evidence

Within the last few years, adrenal cortical tumors with features concordant with the diagnostic criteria attributed to oncocytomas have been reported. To date, only nine reported cases exist in the literature. This report is the tenth case presentation of a presumptively benign neoplasm of the adrenal gland with a rare differentiation. Oncocytomas are well recognized benign tumors of the thyroid, parathyroid, and salivary glands and of the kidney. Other organs also give rise to these types of tumors, however with less frequency than the former sites. The characteristics generally used to classify a tumor as an oncocytoma include the following criteria: the tumor is 1) usually a solitary circumscribed mass with no gross nor microscopic evidence of metastasis (no tissue nor vascular invasion), 2) fairly bland in terms of mitotic activity and nuclear morphology, and 3) composed of large eosinophillic cells in which the cytoplasm is packed full of mitochondria (Figure 1).

An Introductory Examination of Speech Disfluencies in Spanish–English Bilingual Children Who Do and Do Not Stutter During Narratives

2020 ◽  
Vol 5 (1) ◽  
pp. 131-141
Author(s):  
Cristina Rincon ◽  
Kia Noelle Johnson ◽  
Courtney Byrd
Keyword(s):  
Diagnostic Criteria ◽  
Preliminary Data ◽  
Diagnostic Information ◽  
English Speakers ◽  
Bilingual Children ◽  
English Bilingual ◽  
Developmental Stuttering ◽  
Mean Length Of Utterance

Purpose The purpose of this study is to examine the frequency and type of speech disfluencies (stuttering-like and nonstuttering-like) in bilingual Spanish–English (SE) children who stutter (CWS) to SE children who do not stutter (CWNS) during narrative samples elicited in Spanish and English to provide further diagnostic information for this population and preliminary data toward an expansion of this study. Method Participants included six bilingual SE children (three CWS, three CWNS) ranging in age from 5 years to 7;5 (years;months) and recruited from the surrounding Houston, Texas area. Participants provided a narrative sample in English and Spanish. The frequency of speech disfluencies was tabulated, and mean length of utterance was measured for each sample. Results Results indicate that both talker groups exceed the diagnostic criteria typically used for developmental stuttering. Regardless of the language being spoken, CWS participants had a frequency of stuttering-like speech disfluencies that met or exceeded the diagnostic criteria for developmental stuttering that is based on monolingual English speakers. The CWNS participants varied in meeting the criteria depending on the language being spoken, with one of the three CWNS exceeding the criteria in both languages and one exceeding the criteria for percentage of stuttering-like speech disfluencies in one language. Conclusion Findings from this study contribute to the development of more appropriate diagnostic criteria for bilingual SE-speaking children to aid in the reduction of misdiagnoses of stuttering in this population.

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