PS1 - 4. Widespread decreased white matter tract integrity in T1DM patients with microangiopathy and its relation to cognitive functions

ABSTRACT The superior longitudinal fasciculus/arcuate white matter complex (SLF/AC) is the largest and most complex white matter tract of the human cerebrum with multiple inter-linked connections encompassing multiple cognitive functions such as language, attention, memory, emotion, and visuospatial function. However, little is known regarding the overall connectivity of this complex. Recently, the Human Connectome Project parcellated the human cortex into 180 distinct regions. Utilizing diffusion spectrum magnetic resonance imaging tractography coupled with the human cortex parcellation data presented earlier in this supplement, we aim to describe the macro-connectome of the SLF/AC in relation to the linked parcellations present within the human cortex. The purpose of this study is to present this information in an indexed, illustrated, and tractographically aided series of figures and tables for anatomic and clinical reference.

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Cognitive Functions and White Matter Tract Damage in Amyotrophic Lateral Sclerosis: A Diffusion Tensor Tractography Study

American Journal of Neuroradiology ◽

10.3174/ajnr.a2658 ◽

2011 ◽

Vol 32 (10) ◽

pp. 1866-1872 ◽

Cited By ~ 65

Author(s):

L. Sarro ◽

F. Agosta ◽

E. Canu ◽

N. Riva ◽

A. Prelle ◽

...

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

White Matter ◽

Cognitive Functions ◽

Diffusion Tensor ◽

Diffusion Tensor Tractography ◽

White Matter Tract ◽

Tract Damage ◽

Lateral Sclerosis

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A Connectomic Atlas of the Human Cerebrum—Chapter 12: Tractographic Description of the Middle Longitudinal Fasciculus

Operative Neurosurgery ◽

10.1093/ons/opy266 ◽

2018 ◽

Vol 15 (suppl_1) ◽

pp. S429-S435 ◽

Cited By ~ 2

Author(s):

Andrew K Conner ◽

Robert G Briggs ◽

Meherzad Rahimi ◽

Goksel Sali ◽

Cordell M Baker ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

White Matter ◽

Magnetic Resonance ◽

Language Processing ◽

Cognitive Functions ◽

Temporal Region ◽

White Matter Tract ◽

Resonance Imaging ◽

Human Cortex ◽

Auditory Organization

ABSTRACT The middle longitudinal fasciculus (MdLF) is a small and somewhat controversial white matter tract of the human cerebrum, confined to the posterior superior temporal region from which it courses posteriorly to connect at the occipital–parietal interface. The tract appears to be involved in language processing as well as auditory organization and localization, while sub-serving other higher level cognitive functions that have yet to be fully elucidated. Little is known about the specific, interparcellation connections that integrate to form the MdLF. Utilizing diffusion spectrum magnetic resonance imaging tractography coupled with the human cortex parcellation data presented earlier in this supplement, we aim to describe the macro-connectome of the MdLF in relation to the linked parcellations present within the human cortex. The purpose of this study is to present this information in an indexed, illustrated, and tractographically aided series of figures and tables for anatomic and clinical reference.

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Supplemental Material for Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936

Neuropsychology ◽

10.1037/a0033354.supp ◽

2013 ◽

Keyword(s):

White Matter ◽

Older People ◽

Birth Cohort ◽

Cognitive Abilities ◽

Community Dwelling ◽

White Matter Tract ◽

Brain White Matter ◽

Lothian Birth Cohort ◽

Community Dwelling Older People

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Cortically constrained shape recognition: Automated white matter tract segmentation validated in the pediatric brain

Journal of Neuroimaging ◽

10.1111/jon.12854 ◽

2021 ◽

Author(s):

Kesshi M. Jordan ◽

Michael Lauricella ◽

Abigail E. Licata ◽

Simone Sacco ◽

Carlo Asteggiano ◽

...

Keyword(s):

White Matter ◽

Shape Recognition ◽

White Matter Tract ◽

Pediatric Brain

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Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population

Brain Communications ◽

10.1093/braincomms/fcaa238 ◽

2021 ◽

Vol 3 (1) ◽

Author(s):

Konstantinos Poulakis ◽

Robert I Reid ◽

Scott A Przybelski ◽

David S Knopman ◽

Jonathan Graff-Radford ◽

...

Keyword(s):

White Matter ◽

Internal Capsule ◽

Population Based ◽

White Matter Integrity ◽

Ageing Population ◽

White Matter Tract ◽

Imaging Data ◽

Cognitive Assessments ◽

Longitudinal Imaging ◽

Systemic Health

Abstract Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ≥60 years). We found that different clusters (healthy white matter, fast white-matter decliners and intermediate white-matter group) were heterogeneous in the spatial distribution of white-matter integrity, systemic health and cognitive trajectories. White-matter health of specific tracts (genu of corpus callosum, posterior corona radiata and anterior internal capsule) informed about cluster assignments. Not surprisingly, brain amyloidosis was not significantly different between clusters. Clusters had differential white-matter tract vulnerability to ageing (commissural fibres > association/brainstem fibres). Identification of vulnerable white-matter tracts is a valuable approach to assessing risk for cognitive decline.

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