scholarly journals Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Konstantinos Poulakis ◽  
Robert I Reid ◽  
Scott A Przybelski ◽  
David S Knopman ◽  
Jonathan Graff-Radford ◽  
...  
Keyword(s):  
White Matter ◽  
Internal Capsule ◽  
Population Based ◽  
White Matter Integrity ◽  
Ageing Population ◽  
White Matter Tract ◽  
Imaging Data ◽  
Cognitive Assessments ◽  
Longitudinal Imaging ◽  
Systemic Health

Abstract Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ≥60 years). We found that different clusters (healthy white matter, fast white-matter decliners and intermediate white-matter group) were heterogeneous in the spatial distribution of white-matter integrity, systemic health and cognitive trajectories. White-matter health of specific tracts (genu of corpus callosum, posterior corona radiata and anterior internal capsule) informed about cluster assignments. Not surprisingly, brain amyloidosis was not significantly different between clusters. Clusters had differential white-matter tract vulnerability to ageing (commissural fibres > association/brainstem fibres). Identification of vulnerable white-matter tracts is a valuable approach to assessing risk for cognitive decline.

scholarly journals Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Allen A Champagne ◽  
Emile Peponoulas ◽  
Itamar Terem ◽  
Andrew Ross ◽  
Maryam Tayebi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
White Matter Tract ◽  
Exposure Group ◽  
Resonance Imaging ◽  
High Exposure

Abstract Increasing evidence for the cumulative effects of head trauma on structural integrity of the brain has emphasized the need to understand the relationship between tissue mechanic properties and injury susceptibility. Here, diffusion tensor imaging, helmet accelerometers and amplified magnetic resonance imaging were combined to gather insight about the region-specific vulnerability of the corpus callosum to microstructural changes in white-matter integrity upon exposure to sub-concussive impacts. A total of 33 male Canadian football players (meanage = 20.3 ± 1.4 years) were assessed at three time points during a football season (baseline pre-season, mid-season and post-season). The athletes were split into a LOW (N = 16) and HIGH (N = 17) exposure group based on the frequency of sub-concussive impacts sustained on a per-session basis, measured using the helmet-mounted accelerometers. Longitudinal decreases in fractional anisotropy were observed in anterior and posterior regions of the corpus callosum (average cluster size = 40.0 ± 4.4 voxels; P < 0.05, corrected) for athletes from the HIGH exposure group. These results suggest that the white-matter tract may be vulnerable to repetitive sub-concussive collisions sustained over the course of a football season. Using these findings as a basis for further investigation, a novel exploratory analysis of strain derived from sub-voxel motion of brain tissues in response to cardiac impulses was developed using amplified magnetic resonance imaging. This approach revealed specific differences in strain (and thus possibly stiffness) along the white-matter tract (P < 0.0001) suggesting a possible signature relationship between changes in white-matter integrity and tissue mechanical properties. In light of these findings, additional information about the viscoelastic behaviour of white-matter tissues may be imperative in elucidating the mechanisms responsible for region-specific differences in injury susceptibility observed, for instance, through changes in microstructural integrity following exposure to sub-concussive head impacts.

scholarly journals Mini-Basketball Training Program Improves Social Communication and White Matter Integrity in Children with Autism

2020 ◽  
Vol 10 (11) ◽  
pp. 803
Author(s):  
Kelong Cai ◽  
Qian Yu ◽  
Fabian Herold ◽  
Zhimei Liu ◽  
Jingui Wang ◽  
...  
Keyword(s):  
White Matter ◽  
Training Program ◽  
Social Communication ◽  
Exercise Intervention ◽  
Internal Capsule ◽  
Children With Autism ◽  
Exercise Group ◽  
White Matter Integrity ◽  
Control Group ◽  
Children With Asd

Impairments in social communication (SC) represent one of the core symptoms of autism spectrum disorder (ASD). While previous studies have demonstrated that exercise intervention improves SC in children with ASD, there is currently no neuroscientific evidence supporting its benefits. Therefore, we evaluated the outcomes of a long-term exercise intervention on SC and white matter integrity (WMI) in children with ASD, and further explored the neural mechanism of exercise intervention on SC in these children. Twenty-nine children aged 3–6 years with ASD were assigned to either exercise group (n = 15) or control group (n = 14). The exercise group received a scheduled mini-basketball training program (5 sessions per week, forty minutes per session) for 12 consecutive weeks, while the control group was instructed to maintain their daily activities. Groups were assessed before and after intervention on SC and WMI. SC scores were lower in the exercise group post-intervention. Compared with the control group, WMI of the exercise group showed higher fractional anisotropy in the body of corpus callosum, fornix, right cerebral peduncle, left posterior limb of internal capsule, right retrolenticular part of internal capsule, left anterior corona radiate and left superior fronto-occipital fasciculus; lower mean diffusivity in the left anterior corona radiate and the bilateral corticospinal tract. Furthermore, increased WMI was associated with lower scores on a measure of social cognition in the overall sample. This study is the first to provide evidence that exercise intervention improves SC and white matter integrity in children with autism.

scholarly journals Population-Based Tract-To-Region Connectome of the Human Brain and Its Hierarchical Topology

2021 ◽  
Author(s):  
Fang-Cheng Yeh
Keyword(s):  
Individual Differences ◽  
White Matter ◽  
Population Based ◽  
Cortical Region ◽  
White Matter Tract ◽  
Hierarchical Topology ◽  
Information Gap ◽  
Cortical Regions ◽  
Hierarchical Relation ◽  
Population Probability

Abstract Connectome maps region-to-region connectivities but does not inform which white matter pathways form the connections. Here we constructed the first population-based tract-to-region connectome to fill this information gap. The constructed connectome quantifies the population probability of a white matter tract innervating a cortical region. The results show that ~85% of the tract-to-region connectome entries are consistent across individuals, whereas the remaining (~15%) have substantial individual differences requiring individualized mapping. Further hierarchical clustering on cortical regions revealed their parcellations into dorsal, ventral, and limbic networks based on the tract-to-region connective patterns. The clustering results on white matter bundles revealed the connectome-based categorization of fiber bundle systems in the association pathways. This new tract-to-region connectome provides insights into the connective topology between cortical regions and white matter bundles. The derived hierarchical relation further offers a connectome-based categorization of gray matter and white matter structures.

White matter abnormalities in 22q11.2 deletion syndrome patients showing cognitive decline

2017 ◽  
Vol 48 (10) ◽  
pp. 1655-1663 ◽  
Author(s):  
Jasper Olivier Nuninga ◽  
Marc Marijn Bohlken ◽  
Sanne Koops ◽  
Ania M. Fiksinski ◽  
René C. W. Mandl ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Internal Capsule ◽  
22Q11.2 Deletion Syndrome ◽  
Deletion Syndrome ◽  
Psychotic Episode ◽  
Imaging Data ◽  
22Q11.2 Deletion ◽  
White Matter Abnormalities ◽  
Cingulum Bundle

AbstractBackgroundDecline in cognitive functioning precedes the first psychotic episode in the course of schizophrenia and is considered a hallmark symptom of the disorder. Given the low incidence of schizophrenia, it remains a challenge to investigate whether cognitive decline coincides with disease-related changes in brain structure, such as white matter abnormalities. The 22q11.2 deletion syndrome (22q11DS) is an appealing model in this context, as 25% of patients develop psychosis. Furthermore, we recently showed that cognitive decline also precedes the onset of psychosis in individuals with 22q11DS. Here, we investigate whether the early cognitive decline in patients with 22q11DS is associated with alterations in white matter microstructure.MethodsWe compared the fractional anisotropy (FA) of white matter in 22q11DS patients with cognitive decline [n = 16; −18.34 (15.8) VIQ percentile points over 6.80 (2.39) years] to 22q11DS patients without cognitive decline [n = 18; 17.71 (20.17) VIQ percentile points over 5.27 (2.03) years] by applying an atlas-based approach to diffusion-weighted imaging data.ResultsFA was significantly increased (p < 0.05, FDR) in 22q11DS patients with a cognitive decline in the bilateral superior longitudinal fasciculus, the bilateral cingulum bundle, all subcomponents of the left internal capsule and the left superior frontal-occipital fasciculus as compared with 22q11DS patients without cognitive decline.ConclusionsWithin 22q11DS, the early cognitive decline is associated with microstructural differences in white matter. At the mean age of 17.8 years, these changes are reflected in increased FA in several tracts. We hypothesize that similar brain alterations associated with cognitive decline take place early in the trajectory of schizophrenia.

scholarly journals A template-based procedure for determining white matter integrity in the internal capsule early after stroke

2014 ◽  
Vol 4 ◽  
pp. 695-700 ◽  
Author(s):  
Matthew A. Petoe ◽  
Winston D. Byblow ◽  
Esther J.M. de Vries ◽  
Venkatesh Krishnamurthy ◽  
Cathy S. Zhong ◽  
...  
Keyword(s):  
White Matter ◽  
Internal Capsule ◽  
White Matter Integrity

Abstract 1122‐000191: White Matter Tract Integrity After Vascular Insult: Longitudinal Analysis of Hemorrhagic vs Ischemic Lesions

2021 ◽  
Vol 1 (S1) ◽  
Author(s):  
David Rosenbaum‐HaLevi ◽  
Muhammad Haque ◽  
Clark Sitton ◽  
Jaroslaw Aronowski ◽  
Sean I Savitz
Keyword(s):  
White Matter ◽  
Structural Changes ◽  
Cerebrovascular Disorders ◽  
Mean Diffusivity ◽  
Internal Capsule ◽  
Cellular Level ◽  
White Matter Tract ◽  
Posterior Limb ◽  
Injury And Repair ◽  
Over Time

Introduction : White matter tract (WMT) injury occurs in patients with acute cerebrovascular disorders. In this study, we elucidate longitudinal differences in mechanism of injury and repair between ischemic stroke (ISC) and intracerebral hemorrhage (ICH). Methods : Twenty patients (10 ISC and ICH) were prospectively imaged at 1, 3, and 12 months of onset on a 3T MRI. 3D anatomical and DTI images were obtained and integrity of the corticospinal tract (CST) assessed at the ipsi and contralesional posterior limb of internal capsule (PLIC). Fractional anisotropy (FA), mean diffusivity (MD) and pixel volume were recorded. A linear regression model was applied for statistical analysis. Results : ISC group had 4 men, 6 women whereas ICH group had 7 men, 3 women, both with average age 52. Baseline NIHSS in ISC was 11 (IQR = 4.5–20) and ICH 6 (IQR = 2‐13). All lesions were unilateral, hemispheric, completely subcortical or with a significant subcortical component. The average lesion and hematoma volume at 1 month was 37 and 39 cc in ISC and ICH, respectively. The MD in the PLIC of the ISC increased from 1 to 3m (P <0.05) then plateaued, whereas it decreased in ICH over the entire 12m (Fig 1A). The rFA showed a similar pattern of initial injury and then improvement over time in both ISC and ICH (Fig 1B). The ISC group showed 12% WM atrophy in the PLIC at 12m, wheras 13% expansion (P < 0.05) in ICH over this period, after an initial contraction of 14% at 1m (fig 1C‐D). Structural changes of the PLIC correlated with changes in mRS/NIHSS (p<0.05). Conclusions : ISC and ICH display unique patterns of WMT changes over one year in which ICH injury reflects a compression of the CST that resolves over time, while in ISC our data show degeneration and microstructural injury. These changes reflect different mechanisms of injury and remodeling on a cellular level. A better understanding of these changes could improve recovery therapies. Larger studies are needed to better characterize long term WMT changes in IS and ICH.

scholarly journals Reduced anterior internal capsule white matter integrity in primary insomnia

2013 ◽  
Vol 35 (7) ◽  
pp. 3431-3438 ◽  
Author(s):  
Kai Spiegelhalder ◽  
Wolfram Regen ◽  
Martin Prem ◽  
Chiara Baglioni ◽  
Christoph Nissen ◽  
...  
Keyword(s):  
White Matter ◽  
Internal Capsule ◽  
Primary Insomnia ◽  
White Matter Integrity
Sign in / Sign up

Export Citation Format

Share Document