In vivo and in vitro effect of recombinant salmon growth hormone treatment on IGF-I and IGFBPs in yellowtail Seriola quinqueradiata

2009 ◽  
Vol 75 (4) ◽  
pp. 887-894 ◽  
Author(s):  
Fiona L. Pedroso ◽  
Haruhisa Fukada ◽  
Toshiro Masumoto
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Igf I ◽  
Seriola Quinqueradiata ◽  
Vitro Effect

scholarly journals In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3.

1995 ◽  
Vol 9 (2) ◽  
pp. 171-177 ◽  
Author(s):  
A M Gronowski ◽  
Z Zhong ◽  
Z Wen ◽  
M J Thomas ◽  
J E Darnell ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Tyrosine Phosphorylation ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
In Vivo Growth

THE ALDOSTERONE SECRETORY RESPONSE TO SODIUM RESTRICTION IN CHRONICALLY HYPOPHYSECTOMIZED CORTICOTROPHIN-MAINTAINED RATS AS A FUNCTION OF DURATION AND AMOUNT OF GROWTH HORMONE TREATMENT

1971 ◽  
Vol 50 (3) ◽  
pp. 407-411 ◽  
Author(s):  
M. PALKOVITS ◽  
W. de JONG ◽  
B. van der WAL ◽  
D. de WIED
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Secretory Response ◽  
Dependent Manner ◽  
Sodium Restriction ◽  
Hypophysectomized Rats ◽  
Synthetic Capacity ◽  
Dose Dependent

SUMMARY Daily administration of growth hormone (STH) to hypophysectomized rats treated with adrenal maintenance doses of corticotrophin restored the aldosterone secretory response (as measured by the synthetic capacity of the adrenal in vitro) to sodium restriction. Treatment with STH for the first 2 days after hypophysectomy or on the 7th day after hypophysectomy failed, but treatment during the 6th and 7th day after hypophysectomy with 100, 200 or 400 μg STH/day restored the aldosterone secretory response to sodium deprivation in a dose-dependent manner.

In vivo and in vitro effect of growth hormone on estradiol secretion by human granulosa cells.

1993 ◽  
Vol 77 (1) ◽  
pp. 61-67 ◽  
Author(s):  
A Barreca ◽  
P G Artini ◽  
P Del Monte ◽  
P Ponzani ◽  
P Pasquini ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Granulosa Cells ◽  
Human Granulosa Cells ◽  
Estradiol Secretion ◽  
Vitro Effect

scholarly journals Factors affecting IGF-I level and correlation with growth response during growth hormone treatment in LG Growth Study

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0252283
Author(s):  
Ji Hyun Kim ◽  
Su Jin Kim ◽  
Jieun Lee ◽  
Choong Ho Shin ◽  
Ji-Young Seo
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Growth Response ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Hormone Deficiency ◽  
Growth Study ◽  
Korean Children ◽  
Factors Affecting ◽  
Igf I

Growth hormone treatment strategies to achieve the goal include the titration of GH doses according to serum insulin-like growth factor I (IGF-I) concentrations. However, IGF-I levels do not always correlate well with the growth response. This study aims to identify the factors affecting the IGF-I concentration and identify the relationship between IGF-I and the treatment response. The data of prepubertal children treated with recombinant human GH for more than one year were obtained from the LG Growth Study (LGS) Database. This study includes patients with idiopathic growth hormone deficiency (IGHD), organic growth hormone deficiency (OGHD), or Turner syndrome (TS) or small for gestational age (SGA). Among 2,021 participants registered in LGS, 366 subjects were selected, 252 had IGHD, 16 had OGHD, 31 had TS, and 67 were SGA. In the IGHD and SGA groups, IGF-I levels had a positive correlation with weight SDS. There was no significant relationship between the pre-treatment IGF-I level and growth response. However, in the IGHD group, the growth response was significantly higher when the change in the IGF-I SDS value was 1 or more (p = 0.0013). Therefore, IGF-I concentrations should be used as an indicator to monitor the treatment compliance rather than for efficacy determination in Korean children of short stature with GH treatment.

Protein turnover in rat skeletal muscle: effects of hypophysectomy and growth hormone.

1978 ◽  
Vol 234 (1) ◽  
pp. E38 ◽  
Author(s):  
K E Flaim ◽  
J B Li ◽  
L S Jefferson
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Protein Synthesis ◽  
Protein Turnover ◽  
Gastrocnemius Muscle ◽  
Growth Hormone Treatment ◽  
Hormone Replacement ◽  
Hormone Treatment ◽  
Rat Skeletal Muscle

The role of growth hormone in regulating protein turnover was examined in a perfused preparation of rat skeletal muscle. The perfused muscle maintained in vivo levels of ATP and creatine phosphate and exhibited constant rates of oxygen consumption and protein synthesis. Hypophysectomy reduced the rate of protein synthesis, the concentration of RNA, and the efficiency of protein synthesis in gastrocnemius muscle to 30, 46, and 66 percent of normal, respectively. In vivo treatment of hypophysectomized (hypox) rats with bovine growth hormone (250 microgram/day for 5 days) resulted in small increases in protein synthesis and RNA, whereas synthesis/RNA was returned to near normal. Elevation of ribosomal subunits in psoas muscle indicated an inhibition of peptide-chain initiation in hypox rats that was reversed by in vivo growth hormone treatment. Thus, hypox rats exhibited both a decreased capacity and a decreased efficiency of protein synthesis. Growth hormone replacement primarily increased efficiency of protein synthesis. The rate of protein degradation and the activity of cathepsin D in gastrocnemius muscle were decreased by hypophysectomy. Growth hormone treatment had no significant effect on degradation.

SHOXGene Variants: Growth Hormone/IGF-I Status and Response to Growth Hormone Treatment.

2010 ◽  
pp. P3-696-P3-696
Author(s):  
S Shapiro ◽  
ML Klein ◽  
MO Regelmann ◽  
Y Fen ◽  
EJ Wallach ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Igf I
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