A Primary Infection Model for HIV and Immune response with Two Discrete Time Delays

2010 ◽  
Vol 18 (4) ◽  
pp. 385-399 ◽  
Author(s):  
Prashant K. Srivastava ◽  
M. Banerjee ◽  
Peeyush Chandra
2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Hui Miao ◽  
Xamxinur Abdurahman ◽  
Ahmadjan Muhammadhaji

We investigate global dynamics for a system of delay differential equations which describes a virus-immune interaction in vivo. The model has two time delays describing time needed for infection of cell and CTLs generation. Our model admits three possible equilibria: infection-free equilibrium, CTL-absent infection equilibrium, and CTL-present infection equilibrium. The effect of time delay on stability of the equilibria of the CTL immune response model has been studied.


2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Jinhu Xu ◽  
Yan Geng

In this paper, a discrete-time model has been proposed by applying nonstandard finite difference (NSFD) scheme to solve a delayed viral infection model with immune response and general nonlinear incidence. It is shown that the discrete model has equilibria which are exactly the same as those of the original continuous model. Using discrete-time analogue of Lyapunov functionals, the global asymptotic stability of the equilibria of the discrete model is fully determined by the basic reproduction number of the virus and immune response, R0 and R1, with no restriction on the time step size, which implies that the NSFD scheme preserves the qualitative dynamics of the corresponding continuous model.


2019 ◽  
Vol 525 ◽  
pp. 1088-1101 ◽  
Author(s):  
Ranran Cheng ◽  
Mingshu Peng ◽  
Jinchen Yu ◽  
Haifen Li

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