Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study

Introduction: Acute kidney injury is characterized by a sudden decrease in renal function. The objective was to determine the variables that are associated with the need for continuous renal replacement therapy and its outcome in critically ill patients treated in two intensive care units. Methods. A cohort follow-up study with reviewed clinical histories of 140 patients admitted between January-2012 and July-2015, who were receiving continuous therapy, and the main outcome was survival after discharge. Clinical variables, severity scores, disease prognosis, continuous renal replacement techniques and outcomes were collected. Results. Mean age was 61.9±17.6 years, and 60.7% were men. Septic shock was the main cause of acute kidney injury. In total, 79.4% of cases died in the intensive care units. The median dose of continuous renal replacement therapy was 28 ml/kg/hour (interquartile range: 35-37). The late initiation of the therapy between 25-72 hours after the diagnosis increased the probability that the patient would experience a fatal outcome (OR:6.9, 95%CI:1.5-33.0). Conclusions: Acute kidney injury secondary to sepsis is a frequent condition in critically ill patients and is associated with high mortality rates. In these cases, continuous renal replacement therapy was the main recourse for its treatment.

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A national survey of renal replacement therapy prescribing practice for acute kidney injury in Malaysian intensive care units

Nephrology ◽

10.1111/nep.12276 ◽

2014 ◽

Vol 19 (8) ◽

pp. 507-512 ◽

Cited By ~ 7

Author(s):

Janattul-Ain Jamal ◽

Mohd-Basri Mat-Nor ◽

Fariz-Safhan Mohamad-Nor ◽

Andrew A Udy ◽

Jeffrey Lipman ◽

...

Keyword(s):

Acute Kidney Injury ◽

Intensive Care ◽

Renal Replacement Therapy ◽

Replacement Therapy ◽

Intensive Care Units ◽

National Survey ◽

Kidney Injury ◽

Prescribing Practice

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MP243ADVANTAGES OF INTEGRAL MANAGEMENT OF RENAL REPLACEMENT THERAPY IN ACUTE KIDNEY INJURY IN THE INTENSIVE CARE UNITS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfw187.49 ◽

2016 ◽

Vol 31 (suppl_1) ◽

pp. i421-i421

Author(s):

Fernando Liaño ◽

Antonio Gomis-Couto ◽

Angel Candela-Toha ◽

Aurora Lietor ◽

Ana B. Serrano ◽

...

Keyword(s):

Acute Kidney Injury ◽

Intensive Care ◽

Renal Replacement Therapy ◽

Replacement Therapy ◽

Intensive Care Units ◽

Kidney Injury

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Impact of Continuous Renal Replacement Therapy as Treatment for Sepsis-Associated Acute Kidney Injury on Lactate Levels and the Risk of 28-Day Mortality in Intensive Care Units

10.21203/rs.3.rs-152669/v1 ◽

2021 ◽

Author(s):

Luming Zhang ◽

Zichen Wang ◽

Fengshuo Xu ◽

Yinlong Ren ◽

Didi Han ◽

...

Keyword(s):

Acute Kidney Injury ◽

Intensive Care ◽

Renal Replacement Therapy ◽

Continuous Renal Replacement Therapy ◽

Replacement Therapy ◽

Intensive Care Units ◽

Lactate Level ◽

Kidney Injury ◽

Joint Model ◽

Lactate Levels

Abstract Background: Sepsis has high incidence and fatality rates in intensive care units, often leading to renal failure. The effectiveness of continuous renal replacement therapy (CRRT) in sepsis-associated acute kidney injury (S-AKI) patients is currently uncertain.Aim: Joint mode was used to determine the effect of CRRT on the lactate levels and survival of S-AKI patients.Methods: A retrospective study was applied to patients with sepsis and AKI, which were extracted from the MIMIC-III public database, with the endpoint being 28-day mortality. Every lactate level measurement within 28 days was observed and calculated using logarithms. Joint model combined the longitudinal analysis of the natural logarithm of the lactate level [log(lactate)] in longitudinal submodel and Cox regression by trajectory function, demonstrating the effects of CRRT on 28-day survival and log(lactate) changes, and its final relationship with the event status.Results: Among the 717 S-AKI patients, 157 received CRRT. CRRT was not associated with 28-day mortality. After adjustments, the relationship between CRRT use and log(lactate) elevation was statistically significant. The parameter estimation of CRRT and log(lactate) indicated that using CRRT will increase log(lactate) by 0.041 in S-AKI patients. The joint model also instigated a fixed association between changes in the lactate level and the event result, revealing an exp value of (1.755) =5.78, indicating that an increase of one unit in log(lactate) will increase the risk of 28-day mortality 5.78-fold. Conclusion: CRRT does not improve the prognosis of patients with sepsis and acute kidney injury in critical-care units and has a tendency of increasing lactate levels, which is a significant risk factor for the prognosis.

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An epidemiologic overview of acute kidney injury in intensive care units

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.65.8.1094 ◽

2019 ◽

Vol 65 (8) ◽

pp. 1094-1101 ◽

Cited By ~ 1

Author(s):

Reginaldo Passoni dos Santos ◽

Ariana Rodrigues Silva Carvalho ◽

Luis Alberto Batista Peres ◽

Claudio Ronco ◽

Etienne Macedo

Keyword(s):

Acute Kidney Injury ◽

Intensive Care ◽

Renal Replacement Therapy ◽

Replacement Therapy ◽

Intensive Care Units ◽

Latin American ◽

Kidney Injury ◽

Public Health Problem ◽

Mortality Rates ◽

Frequent Event

SUMMARY INTRODUCTION Acute kidney injury (AKI) is a frequent event among critically ill patients hospitalized in intensive care units (ICU) and represents a global public health problem, being imperative an interdisciplinary approach. OBJECTIV To investigate, through literature review, the AKI epidemiology in ICUs. METHODS: Online research in Medline, Scientific Electronic Library Online, and Latin American and Caribbean Literature in Health Sciences databases, with analysis of the most relevant 47 studies published between 2010 and 2017. RESULTS Data of the 67,033 patients from more than 300 ICUs from different regions of the world were analyzed. The overall incidence of AKI ranged from 2.5% to 92.2%, and the mortality from 5% to 80%. The length of ICU stay ranged from five to twenty-one days, and the need for renal replacement therapy from 0.8% to 59.2%. AKI patients had substantially higher mortality rates and longer hospital stays than patients without AKI. CONCLUSION AKI incidence presented high variability among the studies. One of the reasons for that were the different criteria used to define the cases. Availability of local resources, renal replacement therapy needs, serum creatinine at ICU admission, volume overload, and sepsis, among others, influence mortality rates in AKI patients.

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