Differential regional cerebral blood flow reactivity to alterations in end-tidal gases in healthy volunteers

2021 ◽  
Author(s):  
W. Alan C. Mutch ◽  
James Duffin
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
End Tidal

Effect of resolution recovery using graph plots on regional cerebral blood flow in healthy volunteers

2017 ◽  
Vol 31 (7) ◽  
pp. 553-562
Author(s):  
Nobuhiro Yada ◽  
Hideo Onishi ◽  
Masahiro Miyai ◽  
Kentarou Ozasa ◽  
Takashi Katsube ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Resolution Recovery

Regional cerebral blood flow in healthy volunteers measured by the graph plot method with iodoamphetamine SPECT

2010 ◽  
Vol 25 (4) ◽  
pp. 255-260 ◽  
Author(s):  
Kazunari Ishii ◽  
Takafumi Uemura ◽  
Naokazu Miyamoto ◽  
Toshiki Yoshikawa ◽  
Toshiaki Yamaguchi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood

Methylphenidate-induced changes in regional cerebral blood flow: A [15O]H2O PET study in healthy volunteers

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S340-S340
Author(s):  
Joanna I Udo de Haes ◽  
Paul Maguire ◽  
Anne M J Paans ◽  
Piet L Jager ◽  
Johan A den Boer
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Healthy Volunteers ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Induced Changes

Caffeine and Cerebral Blood Flow

1983 ◽  
Vol 143 (6) ◽  
pp. 604-608 ◽  
Author(s):  
Roy J. Mathew ◽  
Deborah L. Barr ◽  
Maxine L. Weinman
Keyword(s):  
Carbon Dioxide ◽  
Blood Pressure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Respiratory Rate ◽  
Regional Cerebral Blood Flow ◽  
Inhalation Technique ◽  
Regional Cerebral Blood ◽  
End Tidal Carbon Dioxide ◽  
End Tidal

SummaryTwo groups of normal volunteers had regional cerebral blood flow (rCBF) measured, by the 133Xenon inhalation technique, before and 30 minutes after 250 mg or 500 mg caffeine given orally. rCBF was measured in a third group of subjects, twice, at a similar interval under identical laboratory conditions. Subjects who received caffeine showed significant decreases in rCBF while the others showed no rCBF change from the first to the second measurement. However, the two caffeine groups did not differ in degrees of rCBF reduction. There were no regional variations in the post-caffeine decrease in cerebral blood flow. The three groups did not show significant changes in end-tidal carbon dioxide, pulse rate, blood pressure, forehead skin temperature and respiratory rate.

The CGRP-Antagonist, BIBN4096BS Does not Affect Cerebral or Systemic Haemodynamics in Healthy Volunteers

Cephalalgia ◽  
2005 ◽  
Vol 25 (2) ◽  
pp. 139-147 ◽  
Author(s):  
KA Petersen ◽  
S Birk ◽  
LH Lassen ◽  
C Kruuse ◽  
O Jonassen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Adverse Events ◽  
Middle Cerebral Artery ◽  
Healthy Volunteers ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Cgrp Antagonist

BIBN4096BS is a CGRP-antagonist effective in the treatment of migraine. Blocking the receptor of a strong vasodilator involves a theoretical risk of causing cerebral vasoconstriction, a probability not previously investigated with BIBN4096BS. Seven healthy volunteers completed this double-blinded placebo-controlled crossover study. The volunteers received randomly 10 min infusions of either placebo, 2.5 mg or 10 mg of BIBN4096BS on 3 separate days. Transcranial Doppler was used to measure the middle cerebral artery blood flow velocity (VMCA); global and regional cerebral blood flow (rCBFMCA) was measured by 133-Xenon inhalation SPECT. The diameter of the temporal and radial artery was measured by highresolution ultrasound. Systemic haemodynamics and partial pressure of CO2 (PetCO2), and adverse events were monitored regularly. BIBN4096BS had no influence on global or regional cerebral blood flow, or on the blood flow velocity in the middle cerebral artery. There was no effect on systemic haemodynamics and adverse events were minor. We conclude that there is no effect of CGRP-receptor blockade on the cerebral or systemic circulation in humans. Circulating CGRP is therefore not likely to exert a vasodilatory activity in the resting state and the use of BIBN4096BS for acute migraine seems to be without risk of cerebral vasoactivity. These data suggest that BIBN4096BS is the first specific antimigraine drug without vasoactive effect.

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