Sol-gel Based Fabrication and Properties of Mg-Zn Doped Bioactive Glass/Gelatin Composite Scaffold for Bone Tissue Engineering

Three-dimensional (3D) mesoporous bioactive glass (MBG) scaffolds were obtained by using the demineralized bone matrix (DBM) and P123 as co-templates through a dip-coating method followed by evaporation induced self-assembly (EISA) process. 3D mesoporous bioactive glass-silk fibroin (MBG/SF) composite scaffolds were prepared by immersing MBG scaffolds into SF solutions with different concentration. Transmission electron microscopy (TEM), field mission scanning electron microscope (FESEM), fourier transform infrared spectroscopy (FT-IR) and wide angle X-ray diffraction (WA-XRD) were used to analyze the inner pore structures, pore sizes, morphologies and composition of the scaffolds. The in vitro bioactivity of the scaffolds was evaluated by soaking in simulated body fluid (SBF). The results showed that the MBG and MBG/SF composite scaffolds with the interconnected macroporous network and mesoporous walls could be obtained by this method. In addition, both the MBG scaffolds and the MBG/SF composite scaffolds have excellent apatite-forming bioactivity. Therefore, this method provides a simple way to prepare scaffolds for bone tissue engineering.

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Sol–gel-derived manganese-releasing bioactive glass as a therapeutic approach for bone tissue engineering

Journal of Materials Science ◽

10.1007/s10853-017-0944-6 ◽

2017 ◽

Vol 52 (15) ◽

pp. 8904-8927 ◽

Cited By ~ 16

Author(s):

Breno Rocha Barrioni ◽

Ana Celeste Oliveira ◽

Maria de Fátima Leite ◽

Marivalda de Magalhães Pereira

Keyword(s):

Tissue Engineering ◽

Bioactive Glass ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Therapeutic Approach ◽

Sol Gel

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Synthesis and Optimization of PCL-Bioactive Glass Composite Scaffold for Bone Tissue Engineering

Materials Today Proceedings ◽

10.1016/j.matpr.2019.05.008 ◽

2019 ◽

Vol 15 ◽

pp. 294-299 ◽

Cited By ~ 2

Author(s):

Raghav Soni ◽

N. Vijay Kumar ◽

Shibu Chameettachal ◽

Falguni Pati ◽

Subha Narayan Rath

Keyword(s):

Tissue Engineering ◽

Bioactive Glass ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Composite Scaffold ◽

Glass Composite

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Biomimetic Fabrication and Characterization of BG/COL/HCA Scaffolds for Bone Tissue Engineering

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.336-338.1574 ◽

2007 ◽

Vol 336-338 ◽

pp. 1574-1576

Author(s):

Xiao Feng Chen ◽

Ying Jun Wang ◽

Chun Rong Yang ◽

Na Ru Zhao

Keyword(s):

Tissue Engineering ◽

Calcium Phosphate ◽

Bioactive Glass ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Type I Collagen ◽

Porous Scaffold ◽

Sol Gel ◽

Type I ◽

Carbonate Apatite

The bone tissue engineering scaffold was developed by compounded the type I collagen with the porous scaffold of the sol-gel derived bioactive glass (BG) in the system CaO-P2O5-SiO2. The resultant porous scaffold was treated in supersaturated calcification solution (SCS) to form the surface layer of hydroxyl-carbonate-apatite (HCA) since the type I collagen possessed good biocompatibility and bio-absorbability, and also, the ability of inducting calcium phosphates to precipitated inside and outside the collagen fibers where the collagen fibers acted as bio-macromolecules template for formation of bone-like inorganic minerals in nature bone such as: octo-calcium phosphate (OCP), tri-calcium phosphate (TCP) and hydroxyl-carbonate-apatite (HCA). On the other hand, the sol-gel derived bioactive glass also played an important role in formation of the above bio-minerals owing to its serial chemical reactions with the body fluid. The in vitro study in supersaturated calcification solution SCS indicated that the surface of the porous scaffold was able to induce formation of bone-like HCA crystals on the pore walls of the scaffold which possessed satisfactory cells biocompatibility.

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