Electrospun Polyhydroxybutyrate/Poly(ε-caprolactone)/58S Sol–Gel Bioactive Glass Hybrid Scaffolds with Highly Improved Osteogenic Potential for Bone Tissue Engineering

2016 ◽  
Vol 8 (27) ◽  
pp. 17098-17108 ◽  
Author(s):  
Yaping Ding ◽  
Wei Li ◽  
Teresa Müller ◽  
Dirk W. Schubert ◽  
Aldo R. Boccaccini ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sol Gel ◽  
Osteogenic Potential ◽  
Hybrid Scaffolds

Sol–gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering

2013 ◽  
Vol 33 (3) ◽  
pp. 1102-1108 ◽  
Author(s):  
Bo Lei ◽  
Kwan-Ha Shin ◽  
Da-Young Noh ◽  
In-Hwan Jo ◽  
Young-Hag Koh ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sol Gel

Sol–gel-derived manganese-releasing bioactive glass as a therapeutic approach for bone tissue engineering

2017 ◽  
Vol 52 (15) ◽  
pp. 8904-8927 ◽  
Author(s):  
Breno Rocha Barrioni ◽  
Ana Celeste Oliveira ◽  
Maria de Fátima Leite ◽  
Marivalda de Magalhães Pereira
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Therapeutic Approach ◽  
Sol Gel

Sol-gel Based Fabrication and Properties of Mg-Zn Doped Bioactive Glass/Gelatin Composite Scaffold for Bone Tissue Engineering

Silicon ◽  
2017 ◽  
Vol 10 (2) ◽  
pp. 667-674 ◽  
Author(s):  
Majid Raz ◽  
Fathollah Moztarzadeh ◽  
Soheila S. Kordestani
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Sol Gel

Biomimetic Fabrication and Characterization of BG/COL/HCA Scaffolds for Bone Tissue Engineering

2007 ◽  
Vol 336-338 ◽  
pp. 1574-1576
Author(s):  
Xiao Feng Chen ◽  
Ying Jun Wang ◽  
Chun Rong Yang ◽  
Na Ru Zhao
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Type I Collagen ◽  
Porous Scaffold ◽  
Sol Gel ◽  
Type I ◽  
Carbonate Apatite

The bone tissue engineering scaffold was developed by compounded the type I collagen with the porous scaffold of the sol-gel derived bioactive glass (BG) in the system CaO-P2O5-SiO2. The resultant porous scaffold was treated in supersaturated calcification solution (SCS) to form the surface layer of hydroxyl-carbonate-apatite (HCA) since the type I collagen possessed good biocompatibility and bio-absorbability, and also, the ability of inducting calcium phosphates to precipitated inside and outside the collagen fibers where the collagen fibers acted as bio-macromolecules template for formation of bone-like inorganic minerals in nature bone such as: octo-calcium phosphate (OCP), tri-calcium phosphate (TCP) and hydroxyl-carbonate-apatite (HCA). On the other hand, the sol-gel derived bioactive glass also played an important role in formation of the above bio-minerals owing to its serial chemical reactions with the body fluid. The in vitro study in supersaturated calcification solution SCS indicated that the surface of the porous scaffold was able to induce formation of bone-like HCA crystals on the pore walls of the scaffold which possessed satisfactory cells biocompatibility.

Increasing the Potential of Bioactive Glass as a Scaffold for Bone Tissue Engineering

2009 ◽  
Vol 1236 ◽  
Author(s):  
Mohamed Ammar ◽  
Max Kaplan ◽  
Therese Quinn ◽  
Sabrina Jedlicka
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Cells ◽  
Cell Model ◽  
Sol Gel ◽  
Material Surface ◽  
Differentiation Induction

AbstractBioactive glass is known for its potential as a bone scaffold due to its ability to stimulate osteogenesis and differentiation of stem cells into bone cells. In an attempt to investigate if we can increase these potentials, we decorated the structure of the bioactive glass made by the sol-gel technique with 3 peptides sequences from different proteins known for their potentials to stimulate the osteogensis process (fibronectin, BMP-2 and protein kinase CKI). This material was tested with Human Mesenchymal Stem Cells (hMSCs) and MC-3T3 preosteoblasts to see the difference in the effect on uncommitted and committed cells. The bioactive glass sol with and without the peptides was dip coated onto glass cover slips, leading to a film of the material, surface decorated with the peptides of choice. The two cell types were seeded onto the materials in standard proliferation medium without additives for differentiation induction. Cells were also grown on tissue culture treated cover slips with and without differentiation induction media as positive and negative controls, respectively. The cells were grown on the materials for a total of five weeks, and were tested at four time points (weekly from week two) by immunocytochemical assays to investigate the levels of different osteogenic markers (osteopontin, osteocalcin and osteonectin) and by qRT-PCR to investigate the mRNA potential of the same proteins. On the native bioactive glass samples, the hMSCs and the MC-3T3s adhered poorly. On peptide-decorated samples, the hMSC adhered poorly, however, the MC-3T3 cells appear to differentiate at a rate that is equal to or faster than the positive control, indicating that the peptide effect is similar to that achieved by traditional BMP-2 soluble protein techniques. This supports our hypothesis that adding specific peptide sequences known for their effects in cells adhesion, proliferation and differentiation can increase the potential of the bioactive glass as a scaffold for bone tissue engineering. The data, however, leads to some questions regarding the MC-3T3 cell model for use in further studies.

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