Micro-organic basis of functional gastrointestinal (GI) disorders: Role of microRNAs in GI pacemaking cells

Author(s):  
Rajan Singh ◽  
Lai Wei ◽  
Uday C. Ghoshal
Keyword(s):  
2019 ◽  
pp. 97-124
Author(s):  
Allan V. Horwitz

From the beginning of the 20th century onward, Freud’s writings concentrated on elucidating the common processes—repression, the unconscious, childhood sexuality, and the libido—that gave rise to both normal and neurotic phenomena. World War I then turned his attention to external traumas and the role of the ego in mediating between the conflicting demands of the id on one side and the superego and civilization on the other. Freud’s lasting contribution to thinking about mental illness was to successfully expand the range of disorders well beyond conditions thought to have an organic basis or the psychoses. Neuroses resulted from interactions between individuals and their human environments: no physical defect needed to be present. Psychiatrists came to have legitimate claims to treat distressing states that had previously been viewed as purely psychogenic in nature and therefore outside of the medical or neurological realm. Moreover, his blurring of the boundaries between the neuroses and normality created a zone of ambiguity that mental health professionals came to exploit. They came to treat a vast expanse of common occurrences including interpersonal conflicts, the psychic results of traumas, and everyday problems of living.


Neurology ◽  
2018 ◽  
Vol 90 (12) ◽  
pp. 563-567 ◽  
Author(s):  
Bart Lutters ◽  
Paul Foley ◽  
Peter J. Koehler

We commemorate the centenary of Constantin von Economo's description of encephalitis lethargica, a mysterious disease that had a significant effect on 20th-century neuroscience. In the acute phase, encephalitis lethargica was marked by intractable somnolence, which von Economo attributed to lesions in the diencephalon, thereby paving the way for future efforts to localize the regulation of sleep in the subcortical brain. At the same time, neuropathologic findings in postencephalitic parkinsonism affirmed the role of the substantia nigra in the pathophysiology of parkinsonism. The occurrence of psychiatric symptoms in patients with encephalitis lethargica—such as mood disorders, obsessive-compulsive behavior, and bradyphrenia—drew attention to the organic basis of mental illness.


1985 ◽  
Vol 9 (7) ◽  
pp. 135-136 ◽  
Author(s):  
Stephen P. Tyrer

In Britain there are almost 200 pain clinics concerned with the diagnosis and treatment of patients with chronic intractable pain. These patients have frequently run the gamut of medical and surgical services and they are referred to a pain clinic for further assessment and treatment, especially those cases where no organic basis can be found to account for the complaint of pain. Other reasons for referral include specialist treatment only available in a pain clinic, where conventional therapy has failed or where further surgical or medical treatment is not considered justifiable.


JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre

2018 ◽  
Vol 41 ◽  
Author(s):  
Winnifred R. Louis ◽  
Craig McGarty ◽  
Emma F. Thomas ◽  
Catherine E. Amiot ◽  
Fathali M. Moghaddam

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.


2018 ◽  
Vol 41 ◽  
Author(s):  
Kevin Arceneaux

AbstractIntuitions guide decision-making, and looking to the evolutionary history of humans illuminates why some behavioral responses are more intuitive than others. Yet a place remains for cognitive processes to second-guess intuitive responses – that is, to be reflective – and individual differences abound in automatic, intuitive processing as well.


2020 ◽  
Vol 43 ◽  
Author(s):  
Stefen Beeler-Duden ◽  
Meltem Yucel ◽  
Amrisha Vaish

Abstract Tomasello offers a compelling account of the emergence of humans’ sense of obligation. We suggest that more needs to be said about the role of affect in the creation of obligations. We also argue that positive emotions such as gratitude evolved to encourage individuals to fulfill cooperative obligations without the negative quality that Tomasello proposes is inherent in obligations.


2020 ◽  
Vol 43 ◽  
Author(s):  
Andrew Whiten

Abstract The authors do the field of cultural evolution a service by exploring the role of non-social cognition in human cumulative technological culture, truly neglected in comparison with socio-cognitive abilities frequently assumed to be the primary drivers. Some specifics of their delineation of the critical factors are problematic, however. I highlight recent chimpanzee–human comparative findings that should help refine such analyses.


2020 ◽  
Vol 43 ◽  
Author(s):  
Thomas Parr

Abstract This commentary focuses upon the relationship between two themes in the target article: the ways in which a Markov blanket may be defined and the role of precision and salience in mediating the interactions between what is internal and external to a system. These each rest upon the different perspectives we might take while “choosing” a Markov blanket.


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