Abstract. Soil respiration (Rs) is the most important source of carbon dioxide emissions from soil to atmosphere. However, it is unclear what the interactive response of Rs would be to environmental changes such as elevated precipitation, nitrogen (N) deposition and warming, especially in unique temperate desert ecosystems. To investigate this an in situ field experiment was conducted in the Gurbantunggut Desert, northwest China, from September 2014 to October 2016. The results showed that precipitation and N deposition significantly increased Rs, but warming decreased Rs, which was mainly through its impact on the variation of soil moisture at 5 cm depth. In addition, the interactive response of Rs to combinations of the factors was much less than that of any single-factor, and the main interaction being a positive effect, except interaction from increased precipitation and high N deposition (60 kg N ha−1 yr−1). Although Rs was found to be a unimodal change pattern with the variation of soil mositure, soil temperature and soil NH4+-N content, and it was signicantly postively correlated to soil dissloved organic carbon (DOC) and pH, but from a structural equation model found that soil temperature was the most important controlling factor. Those results indicated that Rs was mainly interactively controlled by the soil multi-environmental factors and soil nutrients, and was very sensitive to elevated precipitation, N deposition and warming. But the interactions of multiple factors largely reduced between-year variation of Rs more than any single-factor, suggesting that the carbon cycle in temperate deserts could be profoundly influenced by positive carbon-climate feedbacks.