A Genome-Wide Analysis of mRNA Expression in Human Tooth Germ Stem Cells Treated with Pluronic P85

2016 ◽  
Vol 6 (4) ◽  
pp. 392-402
Author(s):  
Atousa Ataei ◽  
Valeria V. Solovyeva ◽  
Mansour Poorebrahim ◽  
Nataliya L. Blatt ◽  
Ilnur I. Salafutdinov ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mrna Expression ◽  
Tooth Germ ◽  
Human Tooth ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
A Genome ◽  
Human Tooth Germ ◽  
Pluronic P85

In vitro differentiation of human tooth germ stem cells into endothelial- and epithelial-like cells

2014 ◽  
Vol 39 (1) ◽  
pp. 94-103 ◽  
Author(s):  
Ayşegül Doğan ◽  
Selami Demirci ◽  
Fikrettin Şahin
Keyword(s):  
Stem Cells ◽  
Tooth Germ ◽  
Human Tooth ◽  
In Vitro Differentiation ◽  
Human Tooth Germ

Influence of STRO-1 selection on osteogenic potential of human tooth germ derived mesenchymal stem cells

2017 ◽  
Vol 82 ◽  
pp. 293-301 ◽  
Author(s):  
Pinar Ercal ◽  
Gorke G. Pekozer ◽  
Osman Z. Gumru ◽  
Gamze T. Kose ◽  
Mustafa Ramazanoglu
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tooth Germ ◽  
Human Tooth ◽  
Osteogenic Potential ◽  
Human Tooth Germ

Cartilage tissue engineering on macroporous scaffolds using human tooth germ stem cells

2015 ◽  
Vol 11 (3) ◽  
pp. 765-777 ◽  
Author(s):  
A. C. Calikoglu Koyuncu ◽  
G. Gurel Pekozer ◽  
M. Ramazanoglu ◽  
G. Torun Kose ◽  
V. Hasirci
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Cartilage Tissue Engineering ◽  
Tooth Germ ◽  
Cartilage Tissue ◽  
Human Tooth ◽  
Human Tooth Germ

Effect of F68, F127, and P85 Pluronic Block Copolymers on Odontogenic Differentiation of Human Tooth Germ Stem Cells

2013 ◽  
Vol 39 (10) ◽  
pp. 1265-1271 ◽  
Author(s):  
Pakize Neslihan Taşlı ◽  
Mehmet Emir Yalvaç ◽  
Nesimi Sofiev ◽  
Fikrettin Şahin
Keyword(s):  
Stem Cells ◽  
Block Copolymers ◽  
Tooth Germ ◽  
Human Tooth ◽  
Odontogenic Differentiation ◽  
Pluronic Block Copolymers ◽  
Human Tooth Germ

Bmp 2 and Bmp 7 Induce Odonto- And Osteogenesis of Human Tooth Germ Stem Cells

2014 ◽  
Vol 172 (6) ◽  
pp. 3016-3025 ◽  
Author(s):  
P. Neslihan Taşlı ◽  
Safa Aydın ◽  
Mehmet Emir Yalvaç ◽  
Fikrettin Şahin
Keyword(s):  
Stem Cells ◽  
Tooth Germ ◽  
Human Tooth ◽  
Human Tooth Germ

Effect of F68 on cryopreservation of mesenchymal stem cells derived from human tooth germ

2012 ◽  
Vol 29 ◽  
pp. S16
Author(s):  
Ayşegül Doğan ◽  
Mehmet Emir Yalvaç ◽  
Albert Rizvanov ◽  
Fikrettin Şahin
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tooth Germ ◽  
Human Tooth ◽  
Human Tooth Germ

scholarly journals Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells

Blood ◽  
2011 ◽  
Vol 117 (15) ◽  
pp. e142-e150 ◽  
Author(s):  
Motohiko Oshima ◽  
Mitsuhiro Endoh ◽  
Takaho A. Endo ◽  
Tetsuro Toyoda ◽  
Yaeko Nakajima-Takagi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Progenitor Cells ◽  
Embryonic Stem ◽  
Es Cell ◽  
Hematopoietic Stem ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
A Genome

Abstract Forced expression of the transcription factor HoxB4 has been shown to enhance the self-renewal capacity of mouse bone marrow hematopoietic stem cells (HSCs) and confer a long-term repopulating capacity to yolk sac and embryonic stem (ES) cell–derived hematopoietic precursors. The fact that ES cell–derived precursors do not repopulate bone marrow without HoxB4 underscores an important role for HoxB4 in the maturation of ES-derived hematopoietic precursors into long-term repopulating HSCs. However, the precise molecular mechanism underlying this process is barely understood. In this study, we performed a genome-wide analysis of HoxB4 using ES cell–derived hematopoietic stem/progenitor cells. The results revealed many of the genes essential for HSC development to be direct targets of HoxB4, such as Runx1, Scl/Tal1, Gata2, and Gfi1. The expression profiling also showed that HoxB4 indirectly affects the expression of several important genes, such as Lmo2, Erg, Meis1, Pbx1, Nov, AhR, and Hemgn. HoxB4 tended to activate the transcription, but the down-regulation of a significant portion of direct targets suggested its function to be context-dependent. These findings indicate that HoxB4 reprograms a set of key regulator genes to facilitate the maturation of developing HSCs into repopulating cells. Our list of HoxB4 targets also provides novel candidate regulators for HSCs.

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