Covalently crosslinked chitosan-poly(ethylene glycol) hybrid hydrogels to deliver insulin for adipose-derived stem cells encapsulation

2012 ◽  
Vol 21 (4) ◽  
pp. 392-399 ◽  
Author(s):  
Huaping Tan ◽  
Hekun Luan ◽  
Yihang Hu ◽  
Xiaohong Hu
Keyword(s):  
Stem Cells ◽  
Ethylene Glycol ◽  
Adipose Derived Stem Cells ◽  
Poly Ethylene Glycol ◽  
Hybrid Hydrogels ◽  
Crosslinked Chitosan ◽  
Poly Ethylene

Poly (ethylene glycol) hydrogel scaffolds with multiscale porosity for culture of human adipose-derived stem cells

2019 ◽  
Vol 30 (11) ◽  
pp. 895-918 ◽  
Author(s):  
Haley H. Barnett ◽  
Abitha M. Heimbuck ◽  
India Pursell ◽  
Rachel A. Hegab ◽  
Benjamin J. Sawyer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ethylene Glycol ◽  
Adipose Derived Stem Cells ◽  
Poly Ethylene Glycol ◽  
Hydrogel Scaffolds ◽  
Poly Ethylene

Structural engineering to control density, conformation, and bioactivity of the poly(ethylene glycol)-grafted poly(urethane urea) scaffolds

2018 ◽  
Vol 34 (2) ◽  
pp. 209-223
Author(s):  
Shideh Shaneh ◽  
Fatemeh Shokrolahi ◽  
Parvin Shokrollahi ◽  
Hamid Yeganeh ◽  
Hossein Omidian
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ethylene Glycol ◽  
Structural Engineering ◽  
Cell Attachment ◽  
Poly Ethylene Glycol ◽  
Salt Leaching ◽  
The Matrix ◽  
Diphenyl Tetrazolium Bromide ◽  
Poly Ethylene

Poly(urethane urea) scaffolds were fabricated through combined salt leaching and solvent casting methods. The scaffolds were then functionalized via aminolysis with poly(ethylene glycol) (PEG- g-PUU). To compare its bioactivity, gelatin was also grafted onto the aminolyzed poly(urethane urea) surface (Gel- g-PUU). Chemical changes at the surface were then monitored using quantitative/qualitative methods. Grafting with both gelatin and poly(ethylene glycol) remarkably enhanced the wettability of poly(urethane urea). Proliferation of human adipose–derived mesenchymal stem cells on poly(urethane urea) and the modified poly(urethane urea)s was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay. The cell experiment results showed that both the modified poly(urethane urea)s enhanced the attachment and proliferation of human adipose–derived mesenchymal stem cells compared to pure poly(urethane urea). Based on previous reports, while a supportive role is observed at adequate poly(ethylene glycol) graft densities, cell adhesion and proliferation are inhibited at very high grafting densities. To correlate the cell data to poly(ethylene glycol) conformations, the surface tension was measured. Data on human adipose–derived mesenchymal stem cells’ attachment/proliferation and contact angle/surface free energy together showed that the grafting density of poly(ethylene glycol) was regulated by optimizing aminolysis conditions, careful selection of poly(ethylene glycol)’s molecular weight, and bulk properties of the matrix poly(urethane urea). As a result, surface overcrowding and brush conformation of the poly(ethylene glycol) chains were avoided, and human adipose–derived mesenchymal stem cell attachment and proliferation occurred on the PEG- g-PUU scaffold at a comparable level to the Gel- g-PUU.

The role of hydrogen bonding in alginate/poly(acrylamide-co-dimethylacrylamide) and alginate/poly(ethylene glycol) methyl ether methacrylate-based tough hybrid hydrogels

RSC Advances ◽  
2015 ◽  
Vol 5 (71) ◽  
pp. 57678-57685 ◽  
Author(s):  
Zhi Wei Low ◽  
Pei Lin Chee ◽  
Dan Kai ◽  
Xian Jun Loh
Keyword(s):  
Hydrogen Bonding ◽  
Elastic Modulus ◽  
Ethylene Glycol ◽  
Methyl Ether ◽  
Poly Ethylene Glycol ◽  
Hybrid Hydrogels ◽  
Poly Ethylene ◽  
Glycol Methyl Ether ◽  
Poly Acrylamide

Hybrid hydrogels, with an elastic modulus and compressive toughness of 350 kPa and 70 J m−3, was synthesized and reported here.

scholarly journals Poly(3-hydroxybutyrate)/poly(ethylene glycol) scaffolds with different microstructure: the effect on growth of mesenchymal stem cells

3 Biotech ◽  
2018 ◽  
Vol 8 (8) ◽  
Author(s):  
A. P. Bonartsev ◽  
I. I. Zharkova ◽  
V. V. Voinova ◽  
E. S. Kuznetsova ◽  
V. A. Zhuikov ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Effect On Growth

scholarly journals Osteogenic differentiation of human mesenchymal stem cells on poly(ethylene glycol)-variant biomaterials

2009 ◽  
Vol 91A (4) ◽  
pp. 975-984 ◽  
Author(s):  
Tonye Briggs ◽  
Matthew D. Treiser ◽  
Paul F. Holmes ◽  
Joachim Kohn ◽  
Prabhas V. Moghe ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Ethylene Glycol ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cells ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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