FNC inhibits non-small cell lung cancer by activating the mitochondrial apoptosis pathway

2021 ◽  
Author(s):  
Xiang Jing ◽  
Shuai Niu ◽  
Yi Liang ◽  
Huiping Chen ◽  
Ning Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Mitochondrial Apoptosis ◽  
Small Cell Lung ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway

scholarly journals Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Xing Su ◽  
Meng Jiang ◽  
Yueping Li ◽  
Jinglin Zhu ◽  
Chunli Zheng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Synergistic Effect ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Target Prediction ◽  
Small Cell ◽  
High Morbidity ◽  
Systems Pharmacology ◽  
Small Cell Lung ◽  
Apoptosis Pathway

Lung cancer is the most common cause of cancer death with high morbidity and mortality, which non-small-cell lung cancer (NSCLC) accounting for the majority. Traditional Chinese Medicine (TCM) is effective in the treatment of complex diseases, especially cancer. However, TCM is still in the conceptual stage. The interaction between different components remains unknown due to its multicomponent and multitarget characteristics. In this study, compound Liuju formula was taken as an example to isolate compounds with synergistic biological activity through systems pharmacology strategy. Through pharmacokinetic evaluation, 37 potentially active compounds were screened out. Meanwhile, 116 targets of these compounds were obtained by combing with the target prediction model. Through network analysis, we found that multicomponent drugs can present a synergistic effect through regulating inflammatory signaling pathway, invasion pathway, proliferation, and apoptosis pathway. Finally, it was confirmed that the bioactive compounds of compound Liuju formula have not only a killing effect on NSCLC tumor cells but also a synergistic effect on inhibiting the secretion of correlative inflammatory mediators, including TNF-α and IL-1β. The systems pharmacology method was applied in this study, which provides a new direction for analyzing the mechanism of TCM.

scholarly journals MicroRNA-related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (16) ◽  
pp. 22632-22638 ◽  
Author(s):  
Wei Jiang ◽  
Nan Bi ◽  
Wen-Jue Zhang ◽  
Li-Hong Wu ◽  
Li-Pin Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Outcome ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Limited Disease ◽  
Apoptosis Pathway
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