Platinum-zoledronate complex blocks gastric cancer cell proliferation by inducing cell cycle arrest and apoptosis

Tumor Biology ◽  
2016 ◽  
Vol 37 (8) ◽  
pp. 10981-10992 ◽  
Author(s):  
Hui Yang ◽  
Ling Qiu ◽  
Li Zhang ◽  
Gaochao Lv ◽  
Ke Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cycle Arrest ◽  
Gastric Cancer Cell Proliferation

scholarly journals Tectonic 1 accelerates gastric cancer cell proliferation and cell cycle progression in vitro

2015 ◽  
Vol 12 (4) ◽  
pp. 5897-5902 ◽  
Author(s):  
XINBAO WANG ◽  
QIMING YU ◽  
YINGLI ZHANG ◽  
ZHIQIANG LING ◽  
PENGFEI YU
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Cell Cycle Progression ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cycle Progression ◽  
Gastric Cancer Cell Proliferation

scholarly journals Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines

2021 ◽  
Vol 14 (3) ◽  
pp. 230
Author(s):  
Waseem El-Huneidi ◽  
Khuloud Bajbouj ◽  
Jibran Sualeh Muhammad ◽  
Arya Vinod ◽  
Jasmin Shafarin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Carnosic Acid ◽  
Human Gastric Cancer ◽  
Cancer Cell Proliferation ◽  
Human Gastric Cancer Cell ◽  
Gastric Cancer Cell Lines ◽  
Gastric Cancer Cell Proliferation

Gastric cancer is among the most common malignancies worldwide. Due to limited availability of therapeutic options, there is a constant need to find new therapies that could target advanced, recurrent, and metastatic gastric cancer. Carnosic acid is a naturally occurring polyphenolic abietane diterpene derived from Rosmarinus officinalis and reported to have numerous pharmacological effects. In this study, the cytotoxicity assay, Annexin V-FITC/PI, caspases 3, 8, and 9, cell cycle analysis, and Western blotting were used to assess the effect of carnosic acid on the growth and survival of human gastric cancer cell lines (AGS and MKN-45). Our findings showed that carnosic acid inhibited human gastric cancer cell proliferation and survival in a dose-dependent manner. Additionally, carnosic acid is found to inhibit the phosphorylation/activation of Akt and mTOR. Moreover, carnosic acid enhanced the cleavage of PARP and downregulated survivin expression, both being known markers of apoptosis. In conclusion, carnosic acid exhibits antitumor activity against human gastric cancer cells via modulating the Akt-mTOR signaling pathway that plays a crucial role in gastric cancer cell proliferation and survival.

scholarly journals Long non‐coding RNA MIF ‐ AS 1 promotes gastric cancer cell proliferation and reduces apoptosis to upregulate NDUFA 4

2018 ◽  
Vol 109 (12) ◽  
pp. 3714-3725 ◽  
Author(s):  
Linhai Li ◽  
Yuejin Li ◽  
Yingguang Huang ◽  
Yiming Ouyang ◽  
Yu Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Non Coding Rna ◽  
Gastric Cancer Cell Proliferation ◽  
Long Non Coding Rna
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